Patents by Inventor Rudolf Valenta

Rudolf Valenta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment and prevention of house dust mite allergies
    Patent number: 11771760
    Abstract: The present invention relates to a fusion protein having formula (I) X1?Y?X2??(I), wherein X1 and X2 comprise each four to six allergen fragments or variants thereof fused to each other, wherein said allergen fragments are derived from at least two allergens of the genus Dermatophagoides, and wherein Y is a carrier protein.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: October 3, 2023
    Assignee: WORG PHARMACEUTICALS (ZHEJIANG) CO., LTD.
    Inventors: Rudolf Valenta, Mirela Curin, Kuan-Wei Chen, Susanne Vrtala
  • Fusion Protein
    Publication number: 20220048955
    Abstract: The present invention relates to a fusion protein for use in the treatment and/or prevention of a hepatitis B virus infection comprising at least one hepatitis B PreS polypeptide or fragment thereof fused to at least one peptide consisting of an amino acid sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 4.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 17, 2022
    Inventors: Rudolf Valenta, Carolin Cornelius
  • Method for detecting HIV-1-specific antibodies using clade C env polypeptides
    Patent number: 11237166
    Abstract: The present invention relates to a method for detecting and/or quantifying human immunodeficiency virus (HIV) specific antibodies in a sample of a subject comprising the step of determining the presence and/or amount of antibodies binding to a) a peptide consisting of the amino acid sequence AIVCTRPNNNTRKSIRIGPGQVFYT (SEQ. ID No. 1), or b) a homolog having at least 70% identity with a peptide of a), or c) a fragment of a peptide of a) or b) consisting of 15 to 24 amino acid residues in said sample.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: February 1, 2022
    Assignee: Viravaxx AG
    Inventors: Rudolf Valenta, Daniela Gallerano, Elopy N. Sibanda
  • TREATMENT AND PREVENTION OF HOUSE DUST MITE ALLERGIES
    Publication number: 20210128718
    Abstract: The present invention relates to a fusion protein having formula (I) X1?Y?X2 ??(I), wherein X1 and X2 comprise each four to six allergen fragments or variants thereof fused to each other, wherein said allergen fragments are derived from at least two allergens of the genus Dermatophagoides, and wherein Y is a carrier protein.
    Type: Application
    Filed: May 17, 2019
    Publication date: May 6, 2021
    Inventors: Rudolf Valenta, Mirela Curin, Kuan-Wei Chen, Susanne Vrtala
  • Method for Diagnosing a Viral Infection
    Publication number: 20190219576
    Abstract: The present invention relates to a method for detecting and/or quantifying human immunodeficiency virus (HIV) specific antibodies in a sample of a subject comprising the step of determining the presence and/or amount of antibodies binding to a) a peptide consisting of the amino acid sequence AIVCTRPNNNTRKSIRIGPGQVFYT (SEQ. ID No. 1), or b) a homolog having at least 70% identity with a peptide of a), or c) a fragment of a peptide of a) or b) consisting of 15 to 24 amino acid residues in said sample.
    Type: Application
    Filed: October 30, 2018
    Publication date: July 18, 2019
    Inventors: Rudolf Valenta, Daniela Gallerano, Elopy N. Sibanda
  • Solid support comprising HIV-1 clade C envelope peptides for the detection of HIV-1-specific antibodies
    Patent number: 10209257
    Abstract: The present invention relates to a method for detecting and/or quantifying human immunodeficiency virus (HIV) specific antibodies in a sample of a subject comprising the step of determining the presence and/or amount of antibodies binding to a) a peptide consisting of the amino acid sequence AIVCTRPNNNTRKSIRIGPGQVFYT (SEQ ID No. 1), or b) a homolog having at least 70% identity with a peptide of a), or c) a fragment of a peptide of a) or b) consisting of 15 to 24 amino acid residues in said sample.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 19, 2019
    Assignee: Viravaxx AG
    Inventors: Rudolf Valenta, Daniela Gallerano, Elopy N. Sibanda
  • Fusion Protein
    Publication number: 20180244726
    Abstract: The present invention relates to a fusion protein for use in the treatment and/or prevention of a hepatitis B virus infection comprising at least one hepatitis B PreS polypeptide or fragment thereof fused to at least one peptide consisting of an amino acid sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 4.
    Type: Application
    Filed: September 5, 2016
    Publication date: August 30, 2018
    Applicant: Viravaxx AG
    Inventors: Rudolf Valenta, Carolin Cornelius
  • House dust mite allergen
    Patent number: 9963489
    Abstract: An immobilized polypeptide including a polypeptide bound to a surface of a polypeptide array or a chip, wherein the polypeptide has the amino acid sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:1 lacking the N-terminal methionine, SEQ ID NO:3 lacking the N-terminal methionine, or a combination thereof.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: May 8, 2018
    Assignee: BIOMAY AG
    Inventors: Rudolf Valenta, Margit Weghofer, Susanne Vrtala, Friedrich Horak, Peter Valent, Stefan Florian
  • ANTIBODY CONSTRUCT
    Publication number: 20180022808
    Abstract: The present invention relates to an antibody construct comprising at least one antigen binding site specific for ICAM1 and at least one antigen binding site specific for at least one allergen.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 25, 2018
    Inventors: Christoph Madritsch, Sabine Flicker, Rudolf Valenta, Elisabeth Gader-Maier, Julia Eckl-Dorna, Verena Niederberger, Katharina Blatt, Peter Valent, Isabella Ellinger
  • Peptide carrier fusion proteins as allergy vaccines
    Patent number: 9844591
    Abstract: The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: December 19, 2017
    Assignee: BIOMAY AG
    Inventors: Katarzyna Niespodziana, Margarete Focke-Tejkl, Susanne Vrtala, Srinita Banerjee, Kuan-Wei Chen, Milena Weber, Rudolf Valenta, Katharina Marth
  • HOUSE DUST MITE ALLERGEN
    Publication number: 20170218034
    Abstract: An immobilized polypeptide including a polypeptide bound to a surface of a polypeptide array or a chip, wherein the polypeptide has the amino acid sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:1 lacking the N-terminal methionine, SEQ ID NO:3 lacking the N-terminal methionine, or a combination thereof.
    Type: Application
    Filed: December 16, 2016
    Publication date: August 3, 2017
    Applicant: Biomay AG
    Inventors: Rudolf VALENTA, Margit Weghofer, Susanne Vrtala, Friedrich Horak, Peter Valent, Stefan Florian
  • Method for diagnosing a rhinovirus infection
    Patent number: 9638694
    Abstract: The present invention relates to a pharmaceutical composition comprising at least one peptide consisting of a minimum of 8 and a maximum of 50 amino acid residues comprising amino acid residues 1 to 8 of a rhinovirus capsid protein selected from the group consisting of VP1, VP2, VP3 and VP4.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: May 2, 2017
    Assignee: Viravaxx GmbH
    Inventors: Rudolf Valenta, Katarzyna Niespodziana, Johanna Edlmayr, Dieter Blaas, Verena Niederberger-Leppin, Nikos Papadopoulos, Theresia Popow-Kraupp
  • VACCINE CARRIER
    Publication number: 20160257722
    Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
    Type: Application
    Filed: December 17, 2015
    Publication date: September 8, 2016
    Applicant: BIOMAY AG
    Inventors: Rudolf VALENTA, Margarete Focke-Tejkl, Birgit Linhart, Susanne Vrtala, Renate Reininger, Susanne Spitzauer, Ines Swoboda, Marianne Van Hage, Hans Gronlund, Johanna Tinhofer, Kerstin Westritschnig, Theresia Popow-Kraupp
  • Peptide carrier fusion proteins as allergy vaccines
    Patent number: 9308251
    Abstract: The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: April 12, 2016
    Assignee: BIOMAY AG
    Inventors: Katarzyna Niespodziana, Margarete Focke-Tejkl, Susanne Vrtala, Srinita Banerjee, Kuan-Wei Chen, Milena Weber, Rudolf Valenta, Katharina Marth
  • Vaccine carrier
    Patent number: 9296828
    Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: March 29, 2016
    Assignee: BIOMAY AG
    Inventors: Rudolf Valenta, Margarete Focke-Tejkl, Birgit Linhart, Susanne Vrtala, Peter Valent, Renate Reininger, Susanne Spitzauer, Ines Swoboda, Marianne Van Hage, Hans Grönlund, Johanna Tinhofer, Kerstin Westritschnig, Theresia Popow-Kraupp
  • Hypoallergenic polypeptides for the treatment of house dust mite allergy
    Patent number: 9238062
    Abstract: The present invention relates to a polypeptide comprising the amino acid sequence as shown in SEQ ID NO:9 or 7. The invention further pertains to nucleic acids encoding the polypeptide, pharmaceutical compositions and vaccines.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: January 19, 2016
    Assignee: BIOMAY AG
    Inventors: Kuan-Wei Chen, Susanne Vrtala, Rudolf Valenta
  • Method for Diagnosing a Viral Infection
    Publication number: 20160011193
    Abstract: The present invention relates to a method for detecting and/or quantifying human immunodeficiency virus (HIV) specific antibodies in a sample of a subject comprising the step of determining the presence and/or amount of antibodies binding to a) a peptide consisting of the amino acid sequence AIVCTRPNNNTRKSIRIGPGQVFYT (SEQ ID No. 1), or b) a homolog having at least 70% identity with a peptide of a), or c) a fragment of a peptide of a) or b) consisting of 15 to 24 amino acid residues in said sample.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 14, 2016
    Inventors: Rudolf Valenta, Daniela Gallerano, Elopy N. Sibanda
  • PEPTIDE CARRIER FUSION PROTEINS AS ALLERGY VACCINES
    Publication number: 20150335735
    Abstract: The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.
    Type: Application
    Filed: May 1, 2015
    Publication date: November 26, 2015
    Applicant: BIOMAY AG
    Inventors: Katarzyna NIESPODZIANA, Margarete Focke-Tejkl, Susanne Vrtala, Srinita Banerjee, Kuan-Wei Chen, Milena Weber, Rudolf Valenta, Katharina Marth
  • Wheat allergens
    Patent number: 9173934
    Abstract: The present invention relates to the field of IgE-mediated allergy, particularly occupational asthma such as bakers asthma. More specifically the invention relates to the identification of a novel wheat allergen and the use thereof in therapy and diagnosis of IgE-mediated allergy. Furthermore the present invention provides the use of known peptides and proteins in therapy and diagnosis. The invention also relates to methods for diagnosis and treatment of IgE-mediated allergy in mammals.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: November 3, 2015
    Assignee: Phadia AB
    Inventors: Rudolf Valenta, Claudia Constantin, Santiago Quirce
  • Hypoallergenic hybrid polypeptides for the treatment of allergy
    Patent number: 9103835
    Abstract: The present invention relates to a method for identifying hypoallergenic polypeptides and to a corresponding screening method. The invention further relates to hypoallergenic polypeptides identified by the method of the invention and to the prophylactic and therapeutic use of these polypeptides.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: August 11, 2015
    Assignee: BIOMAY AG
    Inventors: Rudolf Valenta, Birgit Linhart, Margarete Focke-Tejkl, Angela Neubauer, Peter Valent, Katharina Blatt