Abstract: Disclosed herein, in certain embodiments, are methods and kits for diagnosing a subject as having hepatocellular carcinoma (HCC) or lung cancer. In some instances, also described herein are methods of determining the prognosis of the subject having HCC or lung cancer. In additional instances, described herein are methods of determining the specific staging of HCC or lung cancer in a subject.

Abstract: Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

Abstract: Embodiments relate generally to systems and methods for detecting particulate matter in the air. A particulate matter sensor may comprise an airflow channel; a light source configured to pass light through the airflow channel; an airflow generator configured to generate airflow into the airflow channel; a waveguide configured to direct light from the light source after it passes through the airflow channel and scatters off of particulate matter within the airflow channel; a photodiode configured to receive light scattered by the waveguide; and a computing device coupled to the photodiode having a processor and a memory storing instructions which, when executed by the processor, determines a mass concentration of particles in the airflow channel based on an output of the photodiode.

Abstract: A memory management method implemented by a requesting node includes sending first indication information used for indicating a length of memory required by the requesting node and receiving second indication information used for indicating first remote memory provided to the requesting node by a target contributing node in at least one contributing node that can provide remote memory. The method also includes determining, from available virtual addresses, a first virtual address corresponding to the first remote memory, and sending a first data read/write instruction for the first data when first data whose pointer is within a range of the first virtual address needs to be read/written, where the first data read/write instruction includes third indication information, and the third indication information is used for indicating storage space, for storing the first data, in the first remote memory.

Abstract: Disclosed herein are methods, systems, platforms, non-transitory computer-readable medium, services, and kits for determining a cancer type in an individual. Also described herein include methods, systems, platforms, non-transitory computer-readable medium, and compositions for generating a CpG methylation profile database.

Abstract: Disclosed herein are methods and pharmaceutical compositions for the treatment of retinitis pigmentosa, macular degeneration and other retinal conditions by interfering with expression of genes, such as those encoding photoreceptor cell-specific nuclear receptor and neural retina-specific leucine zipper protein, in cells of the eye. These methods and compositions employ nucleic acid based therapies.

Abstract: There is provided a circulator device. The circulator device comprises two magnet-free circulators. Each magnet-free circulator has a forced time variance. The circulator device comprises ports. The two circulators are in the circulator device arranged to have mutually anti-phase time variance. Each of the two circulators is coupled to all of the ports. There is also presented an isolator device comprising such a circulator device. There is also presented a radio transceiver device comprising such a circulator device or isolator device.

Abstract: A memory management method implemented by a requesting node includes sending first indication information used for indicating a length of memory required by the requesting node and receiving second indication information used for indicating first remote memory provided to the requesting node by a target contributing node in at least one contributing node that can provide remote memory. The method also includes determining, from available virtual addresses, a first virtual address corresponding to the first remote memory, and sending a first data read/write instruction for the first data when first data whose pointer is within a range of the first virtual address needs to be read/written, where the first data read/write instruction includes third indication information, and the third indication information is used for indicating storage space, for storing the first data, in the first remote memory.

Abstract: Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer.

Abstract: Provided is a hardware accelerator, central processing unit, and computing device. A hardware accelerator includes a task accelerating unit configured to, in response to a request for a new task issued by a hardware thread, accelerate the processing of the new task and produce a processing result for the task; a task time prediction unit configured to predict the total waiting time of the new task for returning to a specified address associated with the hardware thread. One aspect of this disclosure makes the hardware thread aware of the time to be waited for before getting a processing result, facilitating its task planning accordingly.

Abstract: Provided is a hardware accelerator and method, central processing unit, and computing device. A hardware accelerating method includes, in response to a request for a new task issued by a hardware thread, accelerating processing of the new task and producing a processing result for the task. A predicting step predicts total waiting time of the new task for returning to a specified address associated with the hardware thread.

Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.

Abstract: A multilevel cache-based data read/write method and a computer system. The method includes acquiring a query address of a physical memory data block in which data is to be read/written, acquiring a cache location attribute of the physical memory data block, querying whether a cache is hit until one cache is hit or all caches are missed, where the querying is performed according to the query address in descending order of levels of caches storable for the physical memory data block, and the levels of the caches are indicated by the cache location attribute, and if one cache is hit, reading/writing the data in the query address of the physical memory data block in the hit cache; or, if all caches are missed, reading/writing the data in the query address of the physical memory data block in a memory.

Abstract: A cross-page prefetching method, apparatus, and system are disclosed, which can improve a prefetching hit ratio of a prefetching device, and further improve efficiency of memory access. The method includes: receiving an indication message, sent by a cache, that a physical address is missing, where the indication message carries a mapped-to first physical address and contiguity information of a first physical page to which the first physical address belongs; acquiring a prefetching address according to the first physical address and a step size that is stored in a prefetching device; and if a page number of a physical page to which the prefetching address belongs is different from a page number of the first physical page, and it is determined, according to the contiguity information of the first physical page, that the first physical page is contiguous, prefetching data at the prefetching address.

Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).

Abstract: A method for establishing an animal model of hepatocellular carcinoma (HCC) bone metastasis, the method including: 1) establishing 97H and LM3 cell clones with stable expression of firefly luciferase (LUC); 2) allowing HCC cells to form bone metastasis in nude mice via intratibial injection; 3) reproducing HCC bone metastasis in nude mice via intracardiac injection of tumor cells; and 4) isolating a sub-population of tumor cells that targets metastasis to bone. The 97H and the LM3 are highly metastatic HCC cell lines transfected with luciferase gene. BALB/cA-nu mice are 4-5 weeks old and maintained in laminar flow cabinets under SPF conditions and received human care throughout an entire study. A cell number for intratibial injection is 0.5×106, and a cell number for intracardiac injection is 1×106.

Abstract: A method for establishing an animal model of hepatocellular carcinoma (HCC) bone metastasis, the method including: 1) establishing 97H and LM3 cell clones with stable expression of firefly luciferase (LUC); 2) allowing HCC cells to form bone metastasis in nude mice via intratibial injection; 3) reproducing HCC bone metastasis in nude mice via intracardiac injection of tumor cells; and 4) isolating a sub-population of tumor cells that targets metastasis to bone. The 97H and the LM3 are highly metastatic HCC cell lines transfected with luciferase gene. BALB/cA-nu mice are 4-5 weeks old and maintained in laminar flow cabinets under SPF conditions and received human care throughout an entire study. A cell number for intratibial injection is 0.5×106, and a cell number for intracardiac injection is 1×106.

Abstract: The disclosure generally relates to compositions and uses thereof to treat vision disorders that affect the normal function of the lens in the eye in a subject having or at risk of developing such vision disorders.

Abstract: The invention provides an isolated limbal stem or progenitor cell (LSC) population or LSC-like population comprising a chemically synthesized, recombinant or isolated nucleic acid encoding PAX6 integrated into a chromosome, or alternatively, not integrated remaining as an extrachromosomal genetic material, wherein the isolated LSC population is substantially free of non-LSC cells or wherein the LSC-like population is substantially free of non-LSC-like cells, or wherein the isolated LSC or LSC-like population is substantially free of non-LSC and non-LSC-like cells and uses thereof.

Abstract: Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with protein aggregation.