Abstract: Provided herein are PLpro inhibitors and methods of treating and/or preventing an infection caused by a coronavirus by administration of one or more of said PLpro inhibitors to a subject in need thereof, as well as pharmaceutical formulations and kits for use in these methods.

Abstract: A visual positioning method and a mobile machine using the same are provided. The method includes: extracting a plurality of corner feature points corresponding to a current image; determining whether a distance between each pair of the plurality of corner feature points is less than a first preset threshold; if yes, determining whether a grayscale value of each of the plurality of corner feature points with the distance less than the first preset threshold is within a second preset threshold range; if yes, obtaining cluster set(s) of the corner feature points; screening a plurality of valid feature points from the cluster set(s); determining a positioning reliability based on a ratio of amount of the valid feature points to an amount of the plurality of corner feature points; and if the positioning reliability is within a preset range, performing a visual positioning based on the positioning reliability.

Abstract: A method for determining lower radius limit of movable throat of shale is provided, and it includes: performing a low-temperature nitrogen adsorption test on a target shale to obtain first pore radii; performing a high-pressure mercury injection test on the target shale to obtain second pore radii; performing a nuclear magnetic resonance test on the target shale to obtain third pore radii; obtaining a relationship diagram of distribution frequencies and pore radii according to three pore radii; distinguishing, according to the pore radii, relationship diagram data, and performing normalization processing to determining a relationship curve of normalized frequency data and the pore radii; and determining a lower radius limit of movable throat of shale according to relationship curve. A problem of describing characteristics of shale occurrence space with complex pore structures and strong heterogeneity is solved, the method is suitable for determining lower radius limit of movable throat of shale.

Abstract: A method for determining lower radius limit of movable throat of shale is provided, and it includes: performing a low-temperature nitrogen adsorption test on a target shale to obtain first pore radii; performing a high-pressure mercury injection test on the target shale to obtain second pore radii; performing a nuclear magnetic resonance test on the target shale to obtain third pore radii; obtaining a relationship diagram of distribution frequencies and pore radii according to three pore radii; distinguishing, according to the pore radii, relationship diagram data, and performing normalization processing to determining a relationship curve of normalized frequency data and the pore radii; and determining a lower radius limit of movable throat of shale according to relationship curve. A problem of describing characteristics of shale occurrence space with complex pore structures and strong heterogeneity is solved, the method is suitable for determining lower radius limit of movable throat of shale.

Abstract: A thermoelectric array display and a manufacturing method thereof are provided. The thermoelectric array display includes at least a first pixel, where the first pixel includes a bottom electrode, a P-type thermoelectric leg, an N-type thermoelectric leg, and a top electrode; the P-type thermoelectric leg is arranged on the bottom electrode; and the P-type thermoelectric leg is connected in series to the N-type thermoelectric leg by the top electrode. The thermoelectric array display has strong concealment of information transmission, can effectively reduce heat generation of a device, and can implement long-distance signal transmission.

Abstract: A task scheduling method and system, and a hardware task scheduler are disclosed, and pertain to the field of computer technologies. The hardware task scheduler provides task scheduling for a central processing unit CPU core to select a candidate task. After selecting the candidate task, the CPU core actively sends metadata of the candidate task to a first storage area, and actively sends a context of the candidate task to a cache, where the first storage area is located in storage space whose access speed is higher than that of a memory. When performing task switching, the CPU core reads the metadata of the candidate task from the first storage area, and reads the context of the candidate task from the cache. In this way, latency of obtaining the metadata and the context of the candidate task by the CPU core is reduced, and low-latency task switching is implemented.

Abstract: Embodiments described herein provide systems and methods for multimodal layout generations for digital publications. The system may receive as inputs, a background image, one or more foreground texts, and one or more foreground images. Feature representations of the background image may be generated. The foreground inputs may be input to a layout generator which has cross attention to the background image feature representations in order to generate a layout comprising of bounding box parameters for each input item. A composite layout may be generated based on the inputs and generated bounding boxes. The resulting composite layout may then be displayed on a user interface.

Abstract: Embodiments include semiconductor processing methods to form low-K films on semiconductor substrates are described. The processing methods may include flowing one or more deposition precursors to a semiconductor processing system, wherein the one or more deposition precursors include a silicon-containing precursor. The silicon-containing precursor may include a carbon chain. The methods may include generating a deposition plasma from the one or more deposition precursors. The methods may include depositing a silicon-and-carbon-containing material on the substrate from plasma effluents of the deposition plasma. The silicon-and-carbon-containing material as-deposited may be characterized by a dielectric constant less than or about 3.0.

Abstract: Embodiments include semiconductor processing methods to form low-? films on semiconductor substrates are described. The processing methods may include flowing one or more deposition precursors to a semiconductor processing system. The one or more deposition precursors may include a silicon-containing precursor that may be a cyclic compound. The methods may include generating a deposition plasma from the one or more deposition precursors. The methods may include depositing a silicon-and-carbon-containing material on the substrate from plasma effluents of the deposition plasma. The silicon-and-carbon-containing material as-deposited may be characterized by a dielectric constant less than or about 3.0.

Abstract: Exemplary semiconductor processing methods may include providing one or more deposition precursors to a processing region of a semiconductor processing chamber. A semiconductor substrate may be positioned within the processing region. The methods may include forming a layer of low dielectric constant material on the semiconductor substrate. The methods may include purging the processing region of the one or more deposition precursors. A plasma power may be maintained at less than or about 750 W while purging the processing region. The methods may include forming an interface layer on the layer of low dielectric constant material. The methods may include forming a cap layer on the interface layer.

Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.

Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method for estimating the state of charge (SOC) of a lithium-ion battery system based on artificial intelligence (AI) is provided. In the method, the relationship between the charging data segments and the SOC of the battery system is established through deep learning, and the SOC at any stage of the charging process can be corrected. SOC in a discharging process is estimated through ampere-hour integration. The estimation method is adaptively updated with a change in the working state of the battery system.

Abstract: A lithium-ion battery system and a control method for combined internal and external heating are provided. A battery is heated in a low-temperature environment through combined internal and external heating. The energy released during self-heating of the battery is fully used, and rapid heating of the battery in the low-temperature environment is implemented. A current adjustment module in a heating module is controlled to adjust a switch on-off frequency and a current on-off time during the heating, and loops with different heating resistances in a multi-loop heating film are selected through a resistance adjustment switch. In this way, target heating requirements of the battery are met, such as a high heating rate in a low-temperature environment, low energy consumption during the heating, and a small impact on battery life without jeopardizing safety during the heating.

Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method for estimating the state of charge (SOC) of a lithium-ion battery system based on artificial intelligence (AI) is provided. In the method, the relationship between the charging data segments and the SOC of the battery system is established through deep learning, and the SOC at any stage of the charging process can be corrected. SOC in a discharging process is estimated through ampere-hour integration. The estimation method is adaptively updated with a change in the working state of the battery system.

Abstract: An artificial intelligence (AI)-based charging curve reconstruction and state estimation method for a lithium-ion battery is provided to estimate various states of a battery. In the method, a complete charging curve is reconstructed through deep learning with charging data segments as input. Then, a plurality of states of the battery can be extracted from the complete charging curve, including a maximum capacity, maximum energy, a state of charge (SOC), a state of energy (SOE), a state of power (SOP), and a capacity increment curve. The battery charging curve reconstruction and state estimation method is adaptively updated with a change in a working state of the battery.

Abstract: A lithium-ion battery system and a control method for combined internal and external heating are provided. A battery is heated in a low-temperature environment through combined internal and external heating. The energy released during self-heating of the battery is fully used, and rapid heating of the battery in the low-temperature environment is implemented. A current adjustment module in a heating module is controlled to adjust a switch on-off frequency and a current on-off time during the heating, and loops with different heating resistances in a multi-loop heating film are selected through a resistance adjustment switch. In this way, target heating requirements of the battery are met, such as a high heating rate in a low-temperature environment, low energy consumption during the heating, and a small impact on battery life without jeopardizing safety during the heating.

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.