Patents by Inventor Ruibao Ren

Ruibao Ren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYL AMIDE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF
    Publication number: 20200325156
    Abstract: The present invention relates to heteroaryl amide compounds, a preparation method therefor, pharmaceutical compositions thereof and applications thereof, and specifically, relates to a type of compounds having broad-spectrum tumor resistant activity, a preparation method therefor, pharmaceutical compositions containing the compounds, and uses of the compounds in the preparation of drugs for treating tumors.
    Type: Application
    Filed: November 2, 2018
    Publication date: October 15, 2020
    Applicants: Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Xiamen University
    Inventors: Ruibao Ren, Xianming Deng, Min Wu, Ting Zhang, Bo Jiao, Qiaofeng Kang, Wei Huang
  • NRAS related cancer therapy
    Patent number: 10781471
    Abstract: The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing novel cancer therapies. Among other things, the present invention encompasses the recognition that targeting RAS palmitoylation can achieve effective therapy for RAS-related cancers. Furthermore, the present invention encompasses the recognition that reduction of ZDHHC9 level and/or activity can significantly reduce palmitoylation level of Ras protein. Among other things, the present invention encompasses the recognition that identification of agents that modulate expression and/or activity of ZDHHC9 can reduce palmitoylation level of Ras protein. In some embodiments, the present invention provides methods of treating a subject suffering from cancer by administering ZDHHC9 inhibition therapy.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 22, 2020
    Assignees: Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Brandeis University
    Inventor: Ruibao Ren
  • Preparation and use of novel protein kinase inhibitors
    Patent number: 10364247
    Abstract: The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: July 30, 2019
    Assignees: Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Xiamen University, Brandeis University
    Inventors: Ruibao Ren, Xianming Deng, Ping Liu, Bo Jiao, Wei Huang
  • PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS
    Publication number: 20180105528
    Abstract: The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.
    Type: Application
    Filed: April 21, 2015
    Publication date: April 19, 2018
    Inventors: Ruibao Ren, Xianming Deng, Ping Liu, Bo Jiao, Wei Huang
  • NRAS RELATED CANCER THERAPY
    Publication number: 20170362633
    Abstract: The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing novel cancer therapies. Among other things, the present invention encompasses the recognition that targeting RAS palmitoylation can achieve effective therapy for RAS-related cancers. Furthermore, the present invention encompasses the recognition that reduction of ZDHHC9 level and/or activity can significantly reduce palmitoylation level of Ras protein. Among other things, the present invention encompasses the recognition that identification of agents that modulate expression and/or activity of ZDHHC9 can reduce palmitoylation level of Ras protein. In some embodiments, the present invention provides methods of treating a subject suffering from cancer by administering ZDHHC9 inhibition therapy.
    Type: Application
    Filed: December 4, 2015
    Publication date: December 21, 2017
    Inventor: Ruibao Ren
  • Cancer therapy
    Patent number: 9220723
    Abstract: The present invention provides agents useful in the treatment of cancer, as well as systems for identifying and/or characterizing such agents, and systems for identifying and/or characterizing patient populations responsive to particular agents.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: December 29, 2015
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Ruibao Ren, Benjamin Cuiffo
  • CANCER THERAPY
    Publication number: 20130210890
    Abstract: The present invention provides agents useful in the treatment of cancer, as well as systems for identifying and/or characterizing such agents, and systems for identifying and/or characterizing patient populations responsive to particular agents.
    Type: Application
    Filed: June 23, 2011
    Publication date: August 15, 2013
    Applicant: BRANDEIS UNIVERSITY
    Inventors: Ruibao Ren, Benjamin Cuiffo
  • IRF-4 AS A TUMOR SUPPRESSOR AND USES THEREOF
    Publication number: 20100260718
    Abstract: The invention relates to methods for treating BCR/ABL mediated disorders. The methods of the invention also include monitoring progression of or sensitivity to treatment of BCR/ABL mediated disorders as well as identifying subjects for the treatment methods of the invention. Screening assays and related products and kits are also encompassed within the invention.
    Type: Application
    Filed: December 10, 2008
    Publication date: October 14, 2010
    Applicant: Brandels University
    Inventor: Ruibao Ren