Abstract: A system and method of removing turbulence from an image of a time ordered sequence of image frames. The method comprises removing effects of turbulence from a first image of the sequence to create an initial corrected image frame; determining a number of iterations required to achieve a desired turbulence removal for a subsequent image in the sequence and satisfy a latency constraint and an available memory capacity; and determining, based on the number of required iterations, a minimum set of image frames required to remove turbulence from the subsequent image. The minimum set of image frames comprises: a number of image frames of the sequence, a number of image frames generated in an intermediate iteration of turbulence removal and the initial corrected image frame. The method further comprises using the minimum set of image frames to remove turbulence from the subsequent image of the sequence.

Abstract: A system and method of removing turbulence from an image of a time ordered sequence of image frames. The method comprises removing effects of turbulence from a first image of the sequence to create an initial corrected image frame; determining a number of iterations required to achieve a desired turbulence removal for a subsequent image in the sequence and satisfy a latency constraint and an available memory capacity; and determining, based on the number of required iterations, a minimum set of image frames required to remove turbulence from the subsequent image. The minimum set of image frames comprises: a number of image frames of the sequence, a number of image frames generated in an intermediate iteration of turbulence removal and the initial corrected image frame. The method further comprises using the minimum set of image frames to remove turbulence from the subsequent image of the sequence.

Abstract: The present disclosure provides a method of correcting for a turbulence effect in a video comprising a plurality of frames. The method comprises determining a first background region and a region corresponding to a moving object in a first frame of the plurality of frames using a predetermined background model. A second background region in a second frame of the plurality of frames is then determined using the predetermined background model. A turbulence-corrected background region from the first background region and the second background region is generated and the region corresponding to the moving object and the turbulence-corrected background region is fused to form a turbulence-corrected frame. The method then updates the predetermined background model based on the turbulence-corrected frame and corrects for the turbulence effect in the second frame using the updated predetermined background model.

Abstract: The present invention relates to isolated immunogenic polypeptides and their use. In one aspect, the isolated immunogenic polypeptide includes a scaffold polypeptide having a hairpin loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond. The scaffold polypeptide directs self-assembly with two other of the scaffold polypeptides to form a trimeric structure, which constrains the one or more epitopes to a conformation that is (i) substantially similar to one or more native pathogen epitopes in trimeric conformation and (ii) capable of binding an antibody reactive to the one or more native pathogen epitopes in trimeric conformation. Another aspect relates to an isolated immunogenic polypeptide that includes a scaffold polypeptide having a native loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond.

Abstract: One or more embodiments of an apparatus, system and method of compensating image data for phase fluctuations caused by a wave deforming medium, and storage or recording mediums for use therewith, are provided herein. At least one embodiment of the method comprises capturing, by a sensor of an imaging system, first image data and second image data for each of a plurality of pixel positions of the sensor, the sensor capturing an object through a wave deforming medium causing a defocus disparity between the first image data and second image data; and determining the defocus disparity between the first image data and the second image data, the defocus disparity corresponding to a defocus wavefront deviation of the wave deforming medium. The method may further comprise compensating the image data captured by the sensor for phase fluctuations caused by the wave deforming medium using the determined defocus disparity.

Abstract: A method determining a retinal pigment epithelium identifies a plurality of regions using captured image data of the eye and fits a curve into at least some of the regions. A curve score is determined associated with the fitted curve using at least a distance between the fitted curve and at least some of the regions in which a contribution of the regions to the curve score is biased towards (asymmetric) regions below the fitted curve. These steps are repeated whereupon one of the fitted curves is selected, using the corresponding associated curve score, for classifying some of the regions as forming at least a part of a retinal pigment epithelium.

Abstract: The present disclosure provides a method of correcting for a turbulence effect in a video comprising a plurality of frames. The method comprises determining a first background region and a region corresponding to a moving object in a first frame of the plurality of frames using a predetermined background model. A second background region in a second frame of the plurality of frames is then determined using the predetermined background model. A turbulence-corrected background region from the first background region and the second background region is generated and the region corresponding to the moving object and the turbulence-corrected background region is fused to form a turbulence-corrected frame. The method then updates the predetermined background model based on the turbulence-corrected frame and corrects for the turbulence effect in the second frame using the updated predetermined background model.

Abstract: One or more embodiments of an apparatus, system and method of compensating image data for phase fluctuations caused by a wave deforming medium, and storage or recording mediums for use therewith, are provided herein. At least one embodiment of the method comprises capturing, by a sensor of an imaging system, first image data and second image data for each of a plurality of pixel positions of the sensor, the sensor capturing an object through a wave deforming medium causing a defocus disparity between the first image data and second image data; and determining the defocus disparity between the first image data and the second image data, the defocus disparity corresponding to a defocus wavefront deviation of the wave deforming medium. The method may further comprise compensating the image data captured by the sensor for phase fluctuations caused by the wave deforming medium using the determined defocus disparity.

Abstract: The present invention relates to isolated immunogenic polypeptides and their use. In one aspect, the isolated immunogenic polypeptide includes a scaffold polypeptide having a hairpin loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond. The scaffold polypeptide directs self-assembly with two other of the scaffold polypeptides to form a trimeric structure, which constrains the one or more epitopes to a conformation that is (i) substantially similar to one or more native pathogen epitopes in trimeric conformation and (ii) capable of binding an antibody reactive to the one or more native pathogen epitopes in trimeric conformation. Another aspect relates to an isolated immunogenic polypeptide that includes a scaffold polypeptide having a native loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond.

Abstract: A method for determining a phase for a captured image, the method comprising forming a demodulated image defining wrapped phase values and modulation values, each being associated with at least one region in the captured image; identifying a position of an edge in the captured image dependent upon the modulation values; determining a position of substantial change in the wrapped phase values in the captured image dependent upon the identified position of the edge, and determining at least one unwrapped phase value based on the position of the edge and the position of the substantial change in the wrapped phase values by shifting a position of the substantial change in the wrapped phase values to the identified position of the edge, so that said unwrapped phase value is adjusted by at least one cycle.

Abstract: A method determining a retinal pigment epithelium identifies a plurality of regions using captured image data of the eye and fits a curve into at least some of the regions. A curve score is determined associated with the fitted curve using at least a distance between the fitted curve and at least some of the regions in which a contribution of the regions to the curve score is biased towards (asymmetric) regions below the fitted curve. These steps are repeated whereupon one of the fitted curves is selected, using the corresponding associated curve score, for classifying some of the regions as forming at least a part of a retinal pigment epithelium.

Abstract: An image processing method is disclosed. An impulse response of a source of an interferometer system is received. An impulse response of a detector of the interferometer system is received. The source impulse response is determined independently of the detector impulse response. An image of an object generated by a grating of the interferometer system is captured, the image is captured by the detector of the interferometer system. The captured image is processed using the determined detector impulse response to attenuate artefacts introduced by the detector. The processed image is demodulated to produce a demodulated image, artefacts introduced by the source being present in the demodulated image. The demodulated image is processed using the source impulse response to reduce the artefacts in the demodulated image introduced by the source.

Abstract: Disclosed is an image de-noising processing method which is particularly suited to X-ray Talbot images. The method captures a fringe pattern from an energy source, the captured fringe pattern having a carrier frequency component dependent on settings of the energy source. Wavelet coefficients are obtained for the captured fringe pattern by applying a wavelet transform to the captured fringe pattern. The method establishes a wavelet coefficients mapping function having a rate of change that varies depending at least on the carrier frequency component of the captured fringe pattern, and transforms the obtained wavelet coefficients using the established wavelet coefficients mapping function. The captured fringe pattern is then processed by applying inverse wavelet transform to the transformed wavelet coefficients to form a denoised fringe pattern.

Abstract: A method for determining a phase for a captured image, the method comprising forming a demodulated image defining wrapped phase values and modulation values, each being associated with at least one region in the captured image; identifying a position of an edge in the captured image dependent upon the modulation values; determining a position of substantial change in the wrapped phase values in the captured image dependent upon the identified position of the edge, and determining at least one unwrapped phase value based on the position of the edge and the position of the substantial change in the wrapped phase values by shifting a position of the substantial change in the wrapped phase values to the identified position of the edge, so that said unwrapped phase value is adjusted by at least one cycle

Abstract: Disclosed is a method of reconstructing a representative detailed phase image from a set of fringe pattern interferogram images of an object. The images are captured by an x-ray interferometer having a crossed diffraction grating. A set of captured fringe pattern interferogram images from the x-ray interferometer are provided, the set comprising no more than eight captured fringe pattern interferogram images. The method determines an estimate of an absorption parameter (a), two-dimensional amplitude modulation parameters (mx, my), and two-dimensional phase modulation parameters (?x and ?y) from a closed-form solution using the received set of captured fringe pattern interferogram images, and reconstructs the representative detailed phase image using the parameter estimates.