Patents by Inventor Ruslana Bryk

Ruslana Bryk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE
    Publication number: 20240132480
    Abstract: Disclosed are compounds for inhibiting lipoamide dehydrogenase (Lpd), and methods of treating tuberculosis.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 25, 2024
    Inventors: John Ginn, Shan SUN, Mayako Michino, Nigel Liverton, Rui Liang, Peter T. Meinke, David Huggins, Ruslana Bryk, Carl F. Nathan
  • Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis
    Patent number: 8338465
    Abstract: Disclosed are methods for the prevention or treatment of tuberculosis in a subject infected with Mycobacterium tuberculosis by administering rhodanine derivatives of formula (I), as well as some novel such compounds. Other embodiments are also disclosed.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: December 25, 2012
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Jasbir Singh, Carl F. Nathan, Ruslana Bryk, Raghu Samy, Krzysztof Pupek, Mark Gurney
  • CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS
    Publication number: 20100210577
    Abstract: Disclosed are methods for the prevention or treatment of tuberculosis in a subject infected with Mycobacterium tuberculosis by administering rhodanine derivatives of formula (I), as well as some novel such compounds. Other embodiments are also disclosed.
    Type: Application
    Filed: June 8, 2007
    Publication date: August 19, 2010
    Inventors: Jasbir Singh, Carl F. Nathan, Ruslana Bryk, Raghu Samy, Krzysztof Pupek, Mark Gurney
  • NOVEL PEROXIREDOXIN DEFENSE SYSTEM FROM MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20070202118
    Abstract: The present invention relates to methods of preventing and treating tuberculosis in a subject infected with Mycobacterium tuberculosis. The method involves inhibiting AhpD in the subject under conditions effective to make the pathogen susceptible to antimicrobial reactive nitrogen intermediates or reactive oxygen intermediates. The present invention also relates to methods of preventing and treating tuberculosis in a subject infected with Mycobacterium tuberculosis involving inhibiting dihydrolipoamide dehydrogenase or dihydrolipoamide succinyltransferase in Mycobacterium tuberculosis in the subject under conditions effective to make the pathogen susceptible to antimicrobial reactive nitrogen intermediates or reactive oxygen intermediates. Also disclosed are methods for identifying candidate compounds suitable for treatment or prevention of tuberculosis.
    Type: Application
    Filed: May 2, 2007
    Publication date: August 30, 2007
    Applicant: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Carl NATHAN, Christopher LIMA, Ruslana BRYK
  • Novel peroxiredoxin defense system from mycobacterium tuberculosis
    Publication number: 20030190325
    Abstract: The present invention relates to methods of preventing and treating tuberculosis in a subject infected with Mycobacterium tuberculosis. The method involves inhibiting AhpD in the subject under conditions effective to make the pathogen susceptible to antimicrobial reactive nitrogen intermediates or reactive oxygen intermediates. The present invention also relates to methods of preventing and treating tuberculosis in a subject infected with Mycobacterium tuberculosis involving inhibiting dihydrolipoamide dehydrogenase or dihydrolipoamide succinyltransferase in Mycobacterium tuberculosis in the subject under conditions effective to make the pathogen susceptible to antimicrobial reactive nitrogen intermediates or reactive oxygen intermediates. Also disclosed are methods for identifying candidate compounds suitable for treatment or prevention of tuberculosis.
    Type: Application
    Filed: January 15, 2003
    Publication date: October 9, 2003
    Inventors: Carl F. Nathan, Christopher D. Lima, Ruslana Bryk