Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Abstract: A infant amusement device for providing amusement and entertainment to an infant by sequentially illuminating a series of multi-colored light sources. The infant amusement device includes an elongate housing designed for mounting to a carry handle of an infant carrier. The housing has a plurality of spaced apart light sources therein. A sequence controller is disposed in the housing and is electrically connected to each of the light sources. The sequence controller illuminates the light sources in a sequential series.