Patents by Inventor Russell J. Coleman
Russell J. Coleman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8716003Abstract: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.Type: GrantFiled: January 4, 2011Date of Patent: May 6, 2014Assignee: CP Kelco U.S., Inc.Inventors: Nancy E. Harding, Yamini N. Patel, Russell J. Coleman
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Patent number: 8709782Abstract: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene M or gene N Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.Type: GrantFiled: January 4, 2011Date of Patent: April 29, 2014Assignee: C.P. Kelco U.S., Inc.Inventors: Nancy E. Harding, Yamini N. Patel, Russell J. Coleman
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Publication number: 20130203153Abstract: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene 1 Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.Type: ApplicationFiled: January 4, 2011Publication date: August 8, 2013Inventors: Nancy E. Harding, Yamini N. Patel, Russell J. Coleman
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Publication number: 20110281334Abstract: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene M or gene N Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.Type: ApplicationFiled: January 4, 2011Publication date: November 17, 2011Inventors: Nancy E. Harding, Yamini N. Patel, Russell J. Coleman
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Publication number: 20110171721Abstract: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.Type: ApplicationFiled: January 4, 2011Publication date: July 14, 2011Applicant: CP KELCO U.S., INC.Inventors: Nancy E. Harding, Yamini N. Patel, Russell J. Coleman
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Patent number: 7888333Abstract: The present invention provides improved diutan polysaccharides produced by mutant Sphingomonas strains containing at least one genetic modification that favors slime-forming diutan production that exhibits increased viscosity. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.Type: GrantFiled: February 3, 2006Date of Patent: February 15, 2011Assignee: CP Kelco U.S., Inc.Inventors: Nancy E. Harding, Yamini N. Patel, Russell J. Coleman
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Publication number: 20110020868Abstract: Compositions and methods for improving expression and/or secretion of a polypeptide of interest in a host cell are provided. Compositions including a coding sequence for a bacterial secretion signal peptide are provided. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space of a host cell, or for increasing secretion of properly processed proteins. In particular, isolated secretion signal peptide-encoding nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the nucleic acid molecules are encompassed. The present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequences shown in SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, and 24, and the nucleotide sequences set forth in SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, and 23, as well as variants and fragments thereof.Type: ApplicationFiled: September 16, 2010Publication date: January 27, 2011Applicant: PFENEX, INC.Inventors: Russell J. Coleman, Diane Retallack, Stacey L. Lee, Charles D. Hershberger
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Patent number: 7833752Abstract: Compositions and methods for improving expression and/or secretion of a polypeptide of interest in a host cell are provided. Compositions including a coding sequence for a bacterial secretion signal peptide are provided. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space of a host cell, or for increasing secretion of properly processed proteins. In particular, isolated secretion signal peptide-encoding nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the nucleic acid molecules are encompassed. The present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequences shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, and 24, and the nucleotide sequences set forth in SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, and 23, as well as variants and fragments thereof.Type: GrantFiled: October 22, 2009Date of Patent: November 16, 2010Assignee: Pfenex, Inc.Inventors: Russell J. Coleman, Diane M. Retallack, Stacey L. Lee, Charles D. Hershberger
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Publication number: 20100137162Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing heterologous protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous protein of interest in a periplasm compartment, or may secrete the heterologous protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest, including therapeutic proteins, hormones, a growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: ApplicationFiled: October 30, 2009Publication date: June 3, 2010Applicant: Pfenex Biopharmaceuticals, Inc.Inventors: Diane M. Retallack, Charles H. Squires, Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charies D. Hershberger
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Publication number: 20100048864Abstract: Compositions and methods for improving expression and/or secretion of a polypeptide of interest in a host cell are provided. Compositions including a coding sequence for a bacterial secretion signal peptide are provided. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space of a host cell, or for increasing secretion of properly processed proteins. In particular, isolated secretion signal peptide-encoding nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the nucleic acid molecules are encompassed. The present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequences shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, and 24, and the nucleotide sequences set forth in SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, and 23, as well as variants and fragments thereof.Type: ApplicationFiled: October 22, 2009Publication date: February 25, 2010Applicant: Dow Global Technologies Inc.Inventors: Russell J. Coleman, Diane Retallack, Charles D. Hershberger, Stacey Lee
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Patent number: 7618799Abstract: Compositions and methods for improving expression and/or secretion of protein or polypeptide of interest in a host cell are provided. Compositions comprising a coding sequence for a bacterial secretion signal peptide are provided. The coding sequences can be used in vector constructs or expression systems for transformation and expression of a protein or polypeptide of interest in a host cell. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space of a host cell, or for increasing secretion of properly processed proteins from the host cell. In particular, isolated secretion signal peptide-encoding nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the nucleic acid molecules are encompassed.Type: GrantFiled: January 30, 2008Date of Patent: November 17, 2009Assignee: Dow Global Technologies IncInventors: Russell J. Coleman, Diane Retallack, Jane C. Schneider, Thomas M. Ramseier, Charles D. Hershberger, Stacey Lee, Sol M. Resnick
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Publication number: 20090062143Abstract: The present invention provides methods and compositions for producing heterologous protein with improved yield and/or quality. A library of randomized ribosomal binding site sequences is provided for the identification of a translation initiation region sequence optimal for expression of the heterologous protein. Also provided are novel ribosomal binding site sequences, and vectors and host cells having those sequences. The library of randomized sequences is useful for screening for improved expression of any protein of interest, including therapeutic proteins, hormones, a growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: ApplicationFiled: August 4, 2008Publication date: March 5, 2009Applicant: Dow Global Technologies Inc.Inventors: Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider
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Publication number: 20080269070Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing heterologous protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous protein of interest in a periplasm compartment, or may secrete the heterologous protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest, including therapeutic proteins, hormones, a growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: ApplicationFiled: April 25, 2008Publication date: October 30, 2008Applicant: Dow Global Technologies, Inc.Inventors: Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charles D. Hershberger
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Publication number: 20080193974Abstract: Compositions and methods for improving expression and/or secretion of protein or polypeptide of interest in a host cell are provided. Compositions comprising a coding sequence for a bacterial secretion signal peptide are provided. The coding sequences can be used in vector constructs or expression systems for transformation and expression of a protein or polypeptide of interest in a host cell. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space of a host cell, or for increasing secretion of properly processed proteins from the host cell. In particular, isolated secretion signal peptide-encoding nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the nucleic acid molecules are encompassed.Type: ApplicationFiled: January 30, 2008Publication date: August 14, 2008Applicant: DOW GLOBAL TECHNOLOGIES, INC.Inventors: Russell J. Coleman, Diane Retallack, Jane C. Schneider, Thomas M. Ramseier, Charles D. Hershberger, Stacey Lee, Sol M. Resnick
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Patent number: 7361754Abstract: Mutational inactivation of proteins involved in para-cresol production in certain milk products results in improved taste and odor. The undesirable para-cresol forms over time as a result of enzymes produced by the bacterium that produces gellan gum. Since the gellan is typically used in a relatively unpurified form, the enzymes are added to the milk along with the gellan. Inactivation of the enzymes is a genetic means of eliminating the enzymes without requiring any additional purification or processing.Type: GrantFiled: June 20, 2005Date of Patent: April 22, 2008Assignee: CP Kelco US, Inc.Inventors: Joseph M. Cleary, Russell J. Coleman, Nancy E. Harding, Yamini N. Patel