Patents by Inventor Rustem F. Ismagilov

Rustem F. Ismagilov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCED NUCLEIC ACID IDENTIFICATION AND DETECTION
    Publication number: 20190352705
    Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
    Type: Application
    Filed: December 18, 2018
    Publication date: November 21, 2019
    Inventors: Rustem F. ISMAGILOV, Bing SUN, Jesus RODRIGUEZ MANZANO, Eugenia KHOROSHEVA, Matthew S. CURTIS
  • PARALLELIZED SAMPLE HANDLING
    Publication number: 20190336969
    Abstract: Provided herein are methods, compositions, and devices for the parallel handling of samples, such as cells or other biological samples. The methods, compositions, and devices are suited for multiple levels of analysis, including genetic and functional assays, of samples.
    Type: Application
    Filed: March 27, 2019
    Publication date: November 7, 2019
    Inventors: Rustem F. ISMAGILOV, Liang MA, Qichao PAN, Mikhail KARYMOV, Toan HUYNH, George SAWICKI, Stefano BEGOLO, Wenbin DU
  • Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
    Patent number: 10370705
    Abstract: Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 6, 2019
    Assignee: University of Chicago
    Inventors: Rustem F. Ismagilov, Feng Shen, Jason E. Kreutz, Bing Sun, Wenbin Du
  • CO-INCUBATING CONFINED MICROBIAL COMMUNITIES
    Publication number: 20190218497
    Abstract: Provided herein are devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 18, 2019
    Inventors: James Q. BOEDICKER, Rustem F. ISMAGILOV, Hyun Jung KIM
  • ANTIBIOTIC SUSCEPTIBILITY OF MICROORGANISMS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20190194726
    Abstract: Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample.
    Type: Application
    Filed: October 11, 2018
    Publication date: June 27, 2019
    Inventors: Rustem F. ISMAGILOV, Emily S. SAVELA, Nathan SCHOEPP, Eric J. LIAW
  • METHODS AND SYSTEMS FOR PERFORMING SINGLE CELL ANALYSIS OF MOLECULES AND MOLECULAR COMPLEXES
    Publication number: 20190144854
    Abstract: Methods, systems and related compositions are provided to perform single-cell marking of a nucleic acid and/or protein in a sample based on in-cell or in-organelle barcoding of nucleic acid and/or protein complexes of the cell or organelle; the methods and systems herein described are configured to provide in-cell or in-organelle single-cell marked nucleic acid and/or protein complexes comprising a single-cell, cell-specific, or a single-cell organelle-specific marker.
    Type: Application
    Filed: September 25, 2018
    Publication date: May 16, 2019
    Inventors: Rustem F. ISMAGILOV, Matthew S. CURTIS, Mary ARRASTIA, David A. SELCK, Mitchell GUTTMAN
  • DEVICE FOR ADDITIVE DELIVERY OF REAGENTS AND RELATED METHODS AND SYSTEMS
    Publication number: 20190118177
    Abstract: A device for allowing compartmentalized reactions with minimized cross-contamination between the compartments, utilizing a delivery of material by loading wells to pooling wells, such that the pooling wells can be additively provided with reactants while maintaining isolation between the pooling wells. The use of geometric properties is used to facilitate transmission of fluids/droplets without the need for hydrophilic surfaces.
    Type: Application
    Filed: September 25, 2018
    Publication date: April 25, 2019
    Inventors: Rustem F. ISMAGILOV, Eugenia KHOROSHEVA, Dmitriy V. ZHUKOV
  • DEVICES AND METHODS FOR AUTONOMOUS MEASUREMENTS
    Publication number: 20190111423
    Abstract: Disclosed herein are devices and methods for storing, processing, preparing and/or analyzing samples. The inventions herein also relate to strategies and methods for automating device operations and for combining multiple devices in an integrated platform.
    Type: Application
    Filed: December 23, 2015
    Publication date: April 18, 2019
    Inventors: Rustem F. ISMAGILOV, Stefano BEGOLO, Jesus Rodriguez MANZANO
  • System and method for movement and timing control
    Patent number: 10207269
    Abstract: The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: February 19, 2019
    Assignee: California Institute of Technology
    Inventors: Rustem F. Ismagilov, Feng Shen, Liang Li, David Selck, Joe Baker, Espir Kahatt, Chris Da Costa
  • Co-incubating confined microbial communities
    Patent number: 10202571
    Abstract: This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: February 12, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: James Q. Boedicker, Rustem F. Ismagilov, Hyun Jung Kim
  • Enhanced nucleic acid identification and detection
    Patent number: 10196684
    Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: February 5, 2019
    Assignee: California Institute of Technology
    Inventors: Rustem F. Ismagilov, Bing Sun, Jesus Rodriguez Manzano, Eugenia Khorosheva, Matthew S. Curtis
  • Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
    Patent number: 10196700
    Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: February 5, 2019
    Assignee: University of Chicago
    Inventors: Rustem F. Ismagilov, Feng Shen, Jason E. Kreutz, Wenbin Du, Bing Sun
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20190030538
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 20, 2018
    Publication date: January 31, 2019
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • DEVICES AND METHODS FOR DIRECT VISUAL DETECTION AND READOUT OF SINGLE NUCLEIC ACID MOLECULES
    Publication number: 20180321137
    Abstract: The present invention relates to methods, computer readable medium and systems for detecting and counting single nucleic acid molecules confined in nanoliter volumes using an unmodified camera, such as a cell phone camera. In particular, it identifies colorimetric amplification-indicator dyes that are compatible with the spectral sensitivity of standard mobile phones. The invention further provides an optimal ratiometric image-process for a selected dye to achieve a readout that is robust to lighting conditions and camera hardware and provides unambiguous quantitative results, even for colorblind users.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Inventors: Rustem F. ISMAGILOV, Jesus Rodriguez MANZANO, Mikhail KARYMOV, David A. SELCK, Stefano BEGOLO, Erik B. JUE, Dmitriy V. ZHUKOV
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 10118174
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 6, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Method for Conducting an Autocatalytic Reaction in Plugs in a Microfluidic System
    Publication number: 20180304268
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: October 25, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 10105703
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: October 23, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • MICROFLUIDIC MEASUREMENTS OF THE RESPONSE OF AN ORGANISM TO A DRUG
    Publication number: 20180274020
    Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.
    Type: Application
    Filed: November 5, 2015
    Publication date: September 27, 2018
    Inventors: Rustem F. ISMAGILOV, Eugenia KHOROSHEVA, Travis S. SCHLAPPI, Matthew S. CURTIS, Nathan G. SCHOEPP, Hedia MAAMAR, Feng SHEN, Erik B. JUE
  • Method for Conducting Reactions Involving Biological Molecules in Plugs in a Microfluidic System
    Publication number: 20180272351
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Publication number: 20180272352
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng