Abstract: A stable lyophilized dosage form of protein is provided that comprises a lyophilate and a reconstitution liquid such that upon reconstitution the formulation will be qualitatively and quantitatively same as that of an already established or developed ready-to-use liquid dosage form of the same protein.

Abstract: The present invention relates to the purification of TNFR:Fc fusion protein. More specifically related to process of purification of TNFR:Fc fusion protein wherein the HCP is reduced. The present invention is directed to the use of mixed-mode chromatography and/or affinity chromatography to produce TNFR:Fc fusion protein which is substantially free of at least one of the protein degrading enzyme present in HCP.

Abstract: The present invention relates to the purification of TNFR:Fc fusion protein. More specifically related to process of purification of TNFR:Fc fusion protein wherein the HCP is reduced. The present invention is directed to the use of mixed-mode chromatography and/or affinity chromatography to produce TNFR:Fc fusion protein which is substantially free of at least one of the protein degrading enzyme present in HCP.

Abstract: The invention provides the mammalian cell culture process for the production of monoclonal antibodies and fusion proteins wherein the mammalian cell is cultured in suitable cell culture conditions specifically maintaining monophasic temperature.

Abstract: A wearable information gathering and processing system is described. The system includes an information obtaining device, the information obtaining device including at least one of a radio frequency identification (RFID) reader, an infra red (IR) detector, a global positioning system (GPS) receiver, a laser measurement device, microphone, or camera. The system also includes a processing device, the processing device including at least one of a voice recognition processor, a gesture recognition processor, or data processor, and an information-providing device coupled to the processing device, the information-providing device including at least one of a heads up display, a speaker, or a vibrator.

Abstract: A vibratory tool for downhole use is capable of letting a wireline or other tools pass a passage therethrough that can be subsequently closed by landing a plug on a seat. The dump valve is disposed annularly about the central passage so that cycling the tool does not cause it to be slammed against a seat. Since only a plug is delivered to a passage the functioning parts already in the housing are made stronger to improve reliability. Additional power is delivered per stroke from modular stacked piston units. The tool can be run in a manner where the high amplitude low frequency oscillating forces are delivered to the stuck fish without impacts of the pistons on the housing.

Abstract: A vibratory tool for downhole use is capable of letting a wireline or other tools pass a passage therethrough that can be subsequently closed by landing a plug on a seat. The dump valve is disposed annularly about the central passage so that cycling the tool does not cause it to be slammed against a seat. Since only a plug is delivered to a passage the functioning parts already in the housing are made stronger to improve reliability. Additional power is delivered per stroke from modular stacked piston units. The tool can be run in a manner where the high amplitude low frequency oscillating forces are delivered to the stuck fish without impacts of the pistons on the housing.

Abstract: A method of downhole milling of an item having high chrome/high nickel content, using polycrystalline diamond cutting elements, exhibiting less wear, requiring less torque and weight, and producing less heat, than prior art tungsten carbide elements.

Abstract: An apparatus for applying a force to a stuck object in a wellbore comprises a work string extending in the wellbore. A vibrating string has a vibrator engaged with the stuck object. The vibrator drives the vibrating string to impart the force to the stuck object. An isolator associated with the work string and the vibrating string decouples a portion of a motion of the vibrating string from the work string. A method of applying a force to a stuck object in a wellbore comprises extending a work string in the wellbore from a surface location. A vibrating string is engaged with the stuck object. The vibrating string is driven at a frequency to apply the force to the stuck object. The work string is isolated from the vibrating string such that a portion of the motion of the vibrating string is decoupled from the work string.

Abstract: A method and apparatus for running a whipstock into a well bore attached to a combination mill and drill bit, releasing the mill/bit from the whipstock, milling a window in the casing, and drilling a lateral well bore, all in one trip. The mill/bit is provided with a primary cutting structure better suited for milling through the casing, and a secondary cutting structure, better suited for drilling through the earth formation. The secondary cutting structure is initially smaller in diameter than the primary cutting structure. The whipstock can be attached to the mill/bit with a shear bolt supported by a boss on the whipstock, with the boss designed to arrest axial motion of the mill/bit after shearing of the bolt.

Abstract: A method of imposing a simple harmonic wave of bidirectional vibration on an object stuck in sand in a well bore, where vibrations are imposed in close proximity to the stuck location, and where the harmonic wave has sufficient amplitude and frequency to create soil liquefaction at the surface of the stuck object, thereby reducing the amount of overpull necessary to free the object from the sand.