Patents by Inventor Ruth E. Shefer
Ruth E. Shefer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10880978Abstract: The present application provides a bipolar x-ray tube module. The bipolar x-ray tube module may include a bipolar x-ray tube and at least two voltage multipliers. The voltage multipliers may be positioned such that the voltage gradient of the first voltage multiplier is substantially parallel to the second voltage multiplier in order to provide a compact configuration.Type: GrantFiled: February 24, 2017Date of Patent: December 29, 2020Assignee: Newton Scientific, Inc.Inventors: Robert E. Klinkowstein, Ruth E. Shefer
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Publication number: 20170251545Abstract: The present application provides a bipolar x-ray tube module. The bipolar x-ray tube module may include a bipolar x-ray tube and at least two voltage multipliers. The voltage multipliers may be positioned such that the voltage gradient of the first voltage multiplier is substantially parallel to the second voltage multiplier in order to provide a compact configuration.Type: ApplicationFiled: February 24, 2017Publication date: August 31, 2017Inventors: Robert E. Klinkowstein, Ruth E. Shefer
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Patent number: 7949099Abstract: An x-ray system is disclosed that includes a bipolar x-ray tube. The bipolar x-ray tube includes two insulators that are separated by an intermediate electrode in an embodiment, wherein each insulator forms a portion of an outer wall of a vacuum envelope of the bipolar x-ray tube surrounding at least a portion of a path of an electron beam within the vacuum envelope. In further embodiments, the bipolar x-ray tube includes a first electrode at a positive high voltage potential with respect to a reference potential, a second electrode at a negative high voltage potential with respect to the reference potential, and an x-ray transmissive window that is at the positive high voltage potential.Type: GrantFiled: July 3, 2008Date of Patent: May 24, 2011Assignee: Newton Scientific Inc.Inventors: Robert E. Klinkowstein, Ruth E. Shefer
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Publication number: 20090010393Abstract: An x-ray system is disclosed that includes a bipolar x-ray tube. The bipolar x-ray tube includes two insulators that are separated by an intermediate electrode in an embodiment, wherein each insulator forms a portion of an outer wall of a vacuum envelope of the bipolar x-ray tube surrounding at least a portion of a path of an electron beam within the vacuum envelope. In further embodiments, the bipolar x-ray tube includes a first electrode at a positive high voltage potential with respect to a reference potential, a second electrode at a negative high voltage potential with respect to the reference potential, and an x-ray transmissive window that is at the positive high voltage potential.Type: ApplicationFiled: July 3, 2008Publication date: January 8, 2009Applicant: NEWTON SCIENTIFIC, INC.Inventors: Robert E. Klinkowstein, Ruth E. Shefer
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Patent number: 7448801Abstract: Described is a self-contained, small, lightweight, power-efficient and radiation-shielded module that includes a miniature vacuum X-ray tube emitting X-rays of a controlled intensity and defined spectrum. Feedback control circuits are used to monitor and maintain the beam current and voltage. The X-ray tube, high-voltage power supply, and the resonant converter are encapsulated in a solid high-voltage insulating material. The module can be configured into complex geometries and can be powered by commercially available small, compact, low-voltage batteries.Type: GrantFiled: February 20, 2003Date of Patent: November 11, 2008Assignees: INPHO, Inc., Newton Scientific Inc.Inventors: Peter E. Oettinger, Francis M. Feda, Ruth E. Shefer, Robert E. Klinkowstein
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Patent number: 7448802Abstract: Described is a self-contained, small, lightweight, power-efficient and radiation-shielded module that includes a miniature vacuum X-ray tube emitting X-rays of a controlled intensity and defined spectrum. Feedback control circuits are used to monitor and maintain the beam current and voltage. The X-ray tube, high-voltage power supply, and the resonant converter are encapsulated in a solid high-voltage insulating material. The module can be configured into complex geometries and can be powered by commercially available small, compact, low-voltage batteries.Type: GrantFiled: January 22, 2004Date of Patent: November 11, 2008Assignees: Newton Scientific, Inc., INPHO, Inc.Inventors: Peter E. Oettinger, Frank M. Feda, Ruth E. Shefer, Robert E. Klinkowstein
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Patent number: 7177392Abstract: An x-ray tube emits X-rays in response to a current control signal. An X-ray detector detects the emitted X-rays and provides a detected X-ray signal indicative thereof to a control system, which provides the current control signal. The X-ray detector provides feedback stabilization of the X-ray output from a source of X-rays, such as, for example an X-ray tube. The detector produces an electrical signal proportional to the X-ray output of the X-ray tube, and that signal is used to control the electron beam current in the tube in order to stabilize the X-ray output of the tube at a predetermined value.Type: GrantFiled: September 10, 2003Date of Patent: February 13, 2007Assignee: Newton Scientific, Inc.Inventors: Ruth E. Shefer, Robert E. Klinkowstein, Earl S. Marmar
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Patent number: 6867415Abstract: An interface for introducing a non-gaseous sample as a predetermined gaseous form into an accelerator mass spectrometer which comprises a nebulizer that receives the non-gaseous sample to provide a fine spray of the sample, a converter that receives at least a portion of said fine spray and converts the desired elements to the predetermined gaseous form and a flow line that transports the predetermined gaseous form to the accelerator mass spectrometer.Type: GrantFiled: August 23, 2001Date of Patent: March 15, 2005Assignees: Newton Scientific, Inc., Massachusetts Institute of TechnologyInventors: Barbara J. Hughey, Paul L. Skipper, John S. Wishnok, Ruth E. Shefer, Naomi A. Fried, John T. Mehl, Steven R. Tannenbaum
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Publication number: 20040109536Abstract: An x-ray tube emits X-rays in response to a current control signal. An X-ray detector detects the emitted X-rays and provides a detected X-ray signal indicative thereof to a control system, which provides the current control signal. The X-ray detector provides feedback stabilization of the X-ray output from a source of X-rays, such as, for example an X-ray tube. The detector produces an electrical signal proportional to the X-ray output of the X-ray tube, and that signal is used to control the electron beam current in the tube in order to stabilize the X-ray output of the tube at a predetermined value.Type: ApplicationFiled: September 10, 2003Publication date: June 10, 2004Inventors: Ruth E. Shefer, Robert E. Klinkowstein, Earl S. Marmar
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Patent number: 6707035Abstract: An interface system for introducing a non-gaseous sample as a predetermined gaseous form into an analytical instrument which comprises a substrate that receives the non-gaseous sample and a directed energy source that heats at least a portion of said substrate containing the non-gaseous sample to convert the sample to the predetermined gaseous form.Type: GrantFiled: August 23, 2001Date of Patent: March 16, 2004Assignees: Newton Scientific, Inc., Massachusetts Institute of TechnologyInventors: Barbara J. Hughey, Paul L. Skipper, John S. Wishnok, Ruth E. Shefer, John T. Mehl, Steven R. Tannenbaum
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Publication number: 20020066857Abstract: An interface system for introducing a non-gaseous sample as a predetermined gaseous form into an analytical instrument which comprises a substrate that receives the non-gaseous sample and a directed energy source that heats at least a portion of said substrate containing the non-gaseous sample to convert the sample to the predetermined gaseous form.Type: ApplicationFiled: August 23, 2001Publication date: June 6, 2002Inventors: Barbara J. Hughey, Paul L. Skipper, John S. Wishnok, Ruth E. Shefer, John T. Mehl, Steven R. Tannenbaum
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Publication number: 20020060288Abstract: An interface for introducing a non-gaseous sample as a predetermined gaseous form into an accelerator mass spectrometer which comprises a nebulizer that receives the non-gaseous sample to provide a fine spray of the sample, a converter that receives at least a portion of said fine spray and converts the desired elements to the predetermined gaseous form and a flow line that transports the predetermined gaseous form to the accelerator mass spectrometer.Type: ApplicationFiled: August 23, 2001Publication date: May 23, 2002Inventors: Barbara J. Hughey, Paul L. Skipper, John S. Wishnok, Ruth E. Shefer, Naomi A. Fried, John T. Mehl, Steven R. Tannenbaum
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Patent number: 6011825Abstract: Radionuclides are produced according to the present invention at commercially significant yields and at specific activities which are suitable for use in radiodiagnostic agents such as PET imaging agents and radiotherapeutic agents and/or compositions. In the method and system of the present invention, a solid target having an isotopically enriched target layer electroplated on an inert substrate is positioned in a specially designed target holder and irradiated with a charged-particle beam. The beam is preferably generated using an accelerator such as a biomedical cyclotron at energies ranging from about 5 MeV to about 25 MeV. The target is preferably directly irradiated, without an intervening attenuating foil, and with the charged particle beam impinging an area which substantially matches the target area.Type: GrantFiled: August 9, 1996Date of Patent: January 4, 2000Assignee: Washington UniversityInventors: Michael J. Welch, Deborah W. McCarthy, Ruth E. Shefer, Robert E. Klinkowstein
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Patent number: 5976066Abstract: In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g.Type: GrantFiled: August 28, 1997Date of Patent: November 2, 1999Assignees: Massachusetts Institute of Technology, Newton Scientific, Inc.Inventors: Jacquelyn C. Yanch, Ruth E. Shefer, Robert E. Klinkowstein
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Patent number: 5468355Abstract: A target is bombarded with high energy particles to generate a radioisotope, and the radioisotope is preferably extracted by one of the following: combusting the target in oxygen, stopping the bombardment and heating the target, or heating the target by induction. Bombardment may take place through a windowless path, and the radioisotope may be used for PET. The particles used may be deuterons or protons, and .sup.13 N may be generated. .sup.11 C may also be generated from either .sup.11 B or .sup.10 B using protons or deuterons. Combustion may be performed by induction heating and may be controlled by the quantity of oxygen available or the temperature. Combustion may be primarily confined to a surface layer and the target may be reused. The beam energy may be 2.2 MeV or less. Another general aspect includes trapping the oxides of .sup.13 N in a trap. The oxides may be converted into .sup.Type: GrantFiled: June 4, 1993Date of Patent: November 21, 1995Assignees: Science Research Laboratory, Washington UniversityInventors: Ruth E. Shefer, Robert E. Klinkowstein, Barbara J. Hughey, Michael J. Welch, Carmen S. Dence