Abstract: The present disclosure provides compositions for and methods of preventing protein aggregation, removing protein aggregates, and improving fluid flux in the brain.

Abstract: Provided herein are medicament delivery systems for selectively providing radial, distal, or a combination radial and distal delivery spray patterns of a medicament, and a method of their use to treat a patient's airway. Generally, a medicament delivery system comprises an elongate shaft, a medicament source, and a means for controlling the delivery spray pattern of the elongate shaft. In use, the medicament delivery system is inserted into a patient's airway during a laryngoscopy procedure to deliver a topical anesthetic to the airway. The medicament delivery device can be used with both direct and indirect view laryngoscopy procedures.

Abstract: The present invention is directed to 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide or a pharmaceutically acceptable salt thereof for the treatment of a disease associated with elevated blood uric acid levels, such as hyperuricemia or gout. The invention is also directed to the tosylate salt of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide.