Patents by Inventor Ruth Moysey
Ruth Moysey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230227799Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: ApplicationFiled: October 18, 2022Publication date: July 20, 2023Applicant: Oxford Nanopore Technologies PLCInventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
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Publication number: 20230212535Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: ApplicationFiled: October 17, 2022Publication date: July 6, 2023Applicant: Oxford Nanopore Technologies PLCInventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
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Patent number: 11634763Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.Type: GrantFiled: June 16, 2020Date of Patent: April 25, 2023Assignee: Oxford Nanopore Technologies PLCInventors: Ruth Moysey, Andrew John Heron
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Patent number: 11525125Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: GrantFiled: June 4, 2020Date of Patent: December 13, 2022Assignee: Oxford Nanopore Technologies PLCInventors: Mark John Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
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Patent number: 11525126Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: GrantFiled: October 6, 2020Date of Patent: December 13, 2022Assignee: Oxford Nanopore Technologies PLCInventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
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Publication number: 20220372568Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or a molecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.Type: ApplicationFiled: May 31, 2022Publication date: November 24, 2022Applicant: Oxford Nanopore Technologies PLCInventors: Ruth Moysey, Andrew John Heron
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Publication number: 20220145383Abstract: The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (SSB). The SSB is either an SSB comprising a carboxy-terminal (C-terminal) region which does not have a net negative charge or a modified SSB comprising one or more modifications in its C-terminal region which decreases the net negative charge of the C-terminal region.Type: ApplicationFiled: September 22, 2021Publication date: May 12, 2022Applicant: Oxford Nanopore Technologies LimitedInventors: James White, Ruth Moysey, Mihaela Misca
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Patent number: 11155860Abstract: The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (SSB). The SSB is either an SSB comprising a carboxy-terminal (C-terminal) region which does not have a net negative charge or a modified SSB comprising one or more modifications in its C-terminal region which decreases the net negative charge of the C-terminal region.Type: GrantFiled: July 18, 2013Date of Patent: October 26, 2021Assignee: Oxford Nanopore Technologies Ltd.Inventors: James White, Ruth Moysey, Mihaela Misca
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Publication number: 20210172011Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or a molecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.Type: ApplicationFiled: June 16, 2020Publication date: June 10, 2021Applicant: Oxford Nanopore Technologies Ltd.Inventors: Ruth Moysey, Andrew John Heron
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Publication number: 20210123032Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: ApplicationFiled: October 6, 2020Publication date: April 29, 2021Applicant: Oxford Nanopore Technologies LimitedInventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Alves, Rebecca Bowen, John Milton
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Publication number: 20210009971Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: ApplicationFiled: June 4, 2020Publication date: January 14, 2021Applicant: Oxford Nanopore Technologies Ltd.Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
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Patent number: 10808231Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: GrantFiled: July 18, 2013Date of Patent: October 20, 2020Assignee: Oxford Nanopore Technologies LimitedInventors: Andrew Heron, James Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Alves, Rebecca Bowen, John Milton
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Patent number: 10724018Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: GrantFiled: September 10, 2014Date of Patent: July 28, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Mark John Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
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Patent number: 10724087Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.Type: GrantFiled: August 11, 2017Date of Patent: July 28, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Ruth Moysey, Andrew John Heron
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Patent number: 10385382Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a RecD helicase. The helicase controls the movement of the target polynucleotide through the pore.Type: GrantFiled: December 28, 2012Date of Patent: August 20, 2019Assignee: Oxford Nanopore Technologies Ltd.Inventors: Ruth Moysey, Andrew John Heron, Szabolcs Soeroes
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Publication number: 20180230526Abstract: The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: ApplicationFiled: September 14, 2017Publication date: August 16, 2018Applicant: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, Mihaela Misca
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Publication number: 20180216175Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.Type: ApplicationFiled: August 11, 2017Publication date: August 2, 2018Applicant: Oxford Nanopore Technologies Ltd.Inventors: Ruth Moysey, Andrew John Heron
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Publication number: 20180037874Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: ApplicationFiled: September 10, 2014Publication date: February 8, 2018Applicant: Oxford Nanopore Technologies Ltd.Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
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Publication number: 20180030530Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.Type: ApplicationFiled: August 11, 2017Publication date: February 1, 2018Applicant: Oxford Nanopore Technologies Ltd.Inventors: Ruth Moysey, Andrew John Heron
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Patent number: 9797009Abstract: The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.Type: GrantFiled: July 18, 2013Date of Patent: October 24, 2017Assignee: Oxford Nanopore Technologies LimitedInventors: Andrew Heron, James Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, Mihaela Misca