Patents by Inventor Ruth Schmid
Ruth Schmid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957793Abstract: The present invention provides a nanoparticle comprising a poly(alkyl cyanoacrylate) homopolymer, or copolymer, at least one active agent and an anionic and radical inhibitor, wherein the anionic and radical inhibitor is a compound having the following formula: wherein R1 is H; and R3, R4, R5, R6 and R7 are independently selected from the group consisting of —H, —OH, C1-C6 alkoxide, C1-C6 alkyl, halides, carboxylic acid, ketone or aldehyde; wherein the anionic and radical inhibitor is present in an amount of 0.001 to 15 wt %, as well as a process suitable for manufacture of the nanoparticle.Type: GrantFiled: August 23, 2019Date of Patent: April 16, 2024Assignee: SINTEF TTO ASInventors: Ruth Schmid, Peter Molesworth, Yrr Mørch, Einar Sulheim, Heidi Johnsen
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Patent number: 11851514Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: GrantFiled: August 27, 2021Date of Patent: December 26, 2023Assignee: Life Technologies ASInventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Patent number: 11806330Abstract: Described herein is an active ingredient encapsulated into poly (alkyl cyanoacrylate) nanoparticles and their use in anti-cancer treatments by intraperitoneal administration.Type: GrantFiled: March 27, 2019Date of Patent: November 7, 2023Assignees: SINTEF TTO AS, OSLO UNIVERSITETSSYKEHUS HFInventors: Yrr Morch, Einar Sulheim, Kjersti Flatmark, Karianne Giller Fleten, Per Stenstad, Heidi Johnsen, Ruth Schmid
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Publication number: 20230138395Abstract: Disclosed are pharmaceutical compositions including a plurality of nanoparticles including a compound of the following structure (1) or a pharmaceutically acceptable salt thereof. Also disclosed are methods of their use and preparation.Type: ApplicationFiled: February 26, 2021Publication date: May 4, 2023Inventors: Peder M. ANDERSEN, Yrr MØRCH, Torsten GOESCH, Håvard SLETTA, Kristin DEGNES, Andreas ÅSLUND, Peter MOLESWORTH, Heidi JOHNSEN, Ruth SCHMID, Eugenia SANDRU, Sven Even BORGOS, Sofie SNIPSTAD, Einar SULHEIM
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Publication number: 20220257525Abstract: Described herein is a hydrophobic anti-cancer drug encapsulated into poly (alkyl cyanoacrylate) nanoparticles and their use in cancer treatments by intracavitary rout of administration such as intraperitoneal administration.Type: ApplicationFiled: September 24, 2021Publication date: August 18, 2022Inventors: Yrr MORCH, Ruth SCHMID, Einar SULHEIM, Per STENSTAD, Heidi JOHNSEN, Kjersti FLATMARK, Karianne Giller FLETEN
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Publication number: 20220160645Abstract: The invention relates to a nanoparticle comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate subunits according to formula 2A, wherein each R1 is independently selected from the group consisting of 2-ethylhexyl, 2-phenylethyl, neopentyl, 1-pentyl, 2-pentyl, 3-pentyl, 3,3-dimethyl-1-butyl, 3-methylbutyl, -heptyl, 2-heptyl, and 3-heptyl; and wherein the nanoparticle further comprises an active agent. The invention also provides compositions comprising the nanoparticles, and the nanoparticles for use in therapy or diagnosis, such as in the treatment of cancer or an infection, or for use in diagnostic imaging.Type: ApplicationFiled: February 26, 2020Publication date: May 26, 2022Applicant: SINTEF TTO ASInventors: Ruth Schmid, Peter Molesworth, Yrr Mørch
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Publication number: 20220056184Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: ApplicationFiled: August 27, 2021Publication date: February 24, 2022Inventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Patent number: 11130833Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: GrantFiled: October 8, 2020Date of Patent: September 28, 2021Assignee: LIFE TECHNOLOGIES ASInventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Publication number: 20210236435Abstract: The present invention provides a nanoparticle comprising a poly(alkyl cyano-acrylate) homopolymer, or copolymer, at least one active agent and an anionic and radical inhibitor, wherein the anionic and radical inhibitor is a compound having the following formula: wherein R1 is H; and R3, R4, R5, R6 and R7 are independently selected from the group consisting of —H, —OH, C1-C6 alkoxide, C1-C6 alkyl, halides, carboxylic acid, ketone or aldehyde; wherein the anionic and radical inhibitor is present in an amount of 0.001 to 15 wt %, as well as a process suitable for manufacture of the nanoparticle.Type: ApplicationFiled: August 23, 2019Publication date: August 5, 2021Inventors: Ruth Schmid, Peter Molesworth, Yrr Mørch, Einar Sulheim, Heidi Johnsen
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Publication number: 20210139626Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: ApplicationFiled: October 8, 2020Publication date: May 13, 2021Inventors: Geir FONNUM, Nils Pontus LUNDBERG, Muhammed Talha GOKMEN, Synne LARSEN, Wilhelm Glomm, Heidi Johnsen, Ruth SCHMID, Lars Kilaas
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Publication number: 20210113482Abstract: The invention is related to the field nanoparticles and medical use. In particular, it relates to cabazitaxel (CBZ) as active ingredient encapsulated into poly (alkyl cyanoacrylate) nanoparticles for use in treatment of cancer.Type: ApplicationFiled: March 27, 2019Publication date: April 22, 2021Inventors: Yrr Mørch, Ruth Schmid, Einar Sulheim, Per Stenstad, Heidi Johnsen, Kirsten Sandvig, Gunhild Mælandsmo, Tore Skotland, Kjersti Flatmark
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Patent number: 10967039Abstract: A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion as herein defined. The invention also relates to nanoparticles produced from said process and to their use in medicine.Type: GrantFiled: May 28, 2014Date of Patent: April 6, 2021Assignee: SINTEF TTO ASInventors: Ruth Schmid, Per Stenstad, Yrr Morch, Heidi Johnsen
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Patent number: 10836854Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: GrantFiled: July 19, 2016Date of Patent: November 17, 2020Assignees: SINTEF, LIFE TECHNOLOGIES ASInventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Publication number: 20200061019Abstract: Described herein is a hydrophobic anti-cancer drug encapsulated into poly (alkyl cyanoacrylate) nanoparticles and their use in cancer treatments by intracavitary rout of administration such as intraperitoneal administration.Type: ApplicationFiled: November 12, 2019Publication date: February 27, 2020Inventors: Yrr Morch, Einar Sulheim, KJersti Flatmark, Karianne Giller Fleten, Per Stenstad, Heidi Johnsen, Ruth Schmid
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Publication number: 20200023073Abstract: The present invention is generally directed to improvements in the treatment of cancer and diseases in the central nervous system. A new drug delivery system is provided, method for producing it and medical uses.Type: ApplicationFiled: September 29, 2017Publication date: January 23, 2020Inventors: YRR MORCH, RUNE HANSEN, RUTH SCHMID, HEIDI JOHNSEN, PER STENSTAD, ANDREAS ASLUND, SOFIE SNIPSTAD, SIGRID BERG, EINAR SULHEIM, CATHARINA DAVIES
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Publication number: 20190298682Abstract: Described herein is an active ingredient encapsulated into poly (alkyl cyanoacrylate) nanoparticles and their use in anti-cancer treatments by intraperitoneal administration.Type: ApplicationFiled: March 27, 2019Publication date: October 3, 2019Inventors: YRR MORCH, EINAR SULHEIM, KJERSTI FLATMARK, KARIANNE GILLER FLETEN, Per Stenstad, Heidi Johnsen, Ruth Schmid
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Publication number: 20180215852Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: ApplicationFiled: July 19, 2016Publication date: August 2, 2018Applicant: SINTEFInventors: Geir FONNUM, Nils LUNDBERG, Muhammed GOKMEN, Synne LARSEN, Wilhelm Glomm, Heidi Johnsen, Ruth SCHMID, Lars Kilaas
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Publication number: 20160129132Abstract: A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion as herein defined. The invention also relates to nanoparticles produced from said process and to their use in medicine.Type: ApplicationFiled: May 28, 2014Publication date: May 12, 2016Applicant: Sinvent ASInventors: Ruth Schmid, Per Stenstad, Yrr Morch, Heidi Johnsen
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Patent number: 9214250Abstract: A heat-treated polymer particle comprising an addition polymer core particle which has had swollen and polymerized therein a blend of an aromatic alcohol with an aldehyde or a blend of an aromatic amine or urea with an aldehyde and which has been subsequently heat treated, e.g. to a temperature of at least 150° C.Type: GrantFiled: October 28, 2011Date of Patent: December 15, 2015Assignee: Conpart ASInventors: Keith Redford, Helge Kristiansen, Heidi Johnsen, Ruth Schmid, Justyna Justynska
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Publication number: 20130277621Abstract: A heat-treated polymer particle comprising an addition polymer core particle which has had swollen and polymerised therein a blend of an aromatic alcohol with an aldehyde or a blend of an aromatic amine or urea with an aldehyde and which has been subsequently heat treated, e.g. to a temperature of at least 150° C.Type: ApplicationFiled: October 28, 2011Publication date: October 24, 2013Applicant: CONPART ASInventors: Keith Redford, Helge Kristiansen, Heidi Johnsen, Ruth Schmid, Justyna Justynska