Patents by Inventor Ruth W. Craig

Ruth W. Craig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mc1-1 gene regulatory elements and a pro-apoptotic mc1-1 variant
    Patent number: 6800750
    Abstract: The present invention relates to a human Mcl-1 gene, to nucleotide sequences that act as regulatory elements for expression of an Mcl-1 gene, to polynucleotides encoding a variant Mcl-1s/&Dgr;TM polypeptide, and to oligonucleotides, which contain at least ten nucleotides and can hybridize specifically to a splice junction of the disclosed Mcl-1 gene or to a polynucleotide encoding an Mcl-1 variant polypeptide as disclosed herein. The invention also relates to an Mcl-1s/&Dgr;TM polypeptide, as well as to antibodies that can interact specifically with an epitope of Mcl-1s/&Dgr;TM, but not with an epitope of the full length Mcl-1 polypeptide. In addition, the invention relates to a method of expressing a nucleic acid molecule in a cell by introducing into the cell the Mcl-1 gene regulatory element as disclosed herein, such that a nucleic acid molecule that is operatively linked to the Mcl-1 gene regulatory element is expressed in the cell.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: October 5, 2004
    Assignees: Dartmouth College, University of Sheffield
    Inventors: Ruth W. Craig, Colin D. Bingle, Moira Whyte
  • Myeloid cell leukemia associated gene MCL-1
    Patent number: 6528263
    Abstract: A gene, mc1-1, of the bc1-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mc1-1 nucleotide and polypeptide sequences.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: March 4, 2003
    Assignee: Dartmouth College
    Inventor: Ruth W. Craig
  • Myeloid cell leukemia associated gene MCL-1
    Publication number: 20020086321
    Abstract: A method is provided for treating a cell proliferative disorder associated with mcl-1 by administering to a subject with the disorder, a therapeutically effective amount of reagent which modulates mcl-1 activity. The reagent can be, for example, an antibody, or a sense or an antisense polynucleotide sequence, which can be contained in a vector or a liposome. The cell proliferative disorder can be hematopoietically derived, for example, myeloid cell leukemia, or of lymphoid origin, for example, a lymphoma.
    Type: Application
    Filed: November 2, 2001
    Publication date: July 4, 2002
    Inventor: Ruth W. Craig
  • Myeloid cell leukemia associated gene mcl-1
    Patent number: 6200763
    Abstract: A gene, mcl-1, of the bcl-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mcl-1 nucleotide and polypeptide sequences.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: March 13, 2001
    Assignee: Dartmouth College
    Inventor: Ruth W. Craig
  • Myeloid cell leukemia associated gene mcl-1
    Patent number: 6020466
    Abstract: A gene, mcl-1, of the bcl-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mcl-1 nucleotide and polypeptide sequences.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: February 1, 2000
    Assignee: Dartmouth College
    Inventor: Ruth W. Craig
  • Myeloid cell leukemia associated gene MCL-1
    Patent number: 5888812
    Abstract: A gene, mcl-1, of the bcl-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mcl-1 nucleotide and polypeptide sequences.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: March 30, 1999
    Assignee: Dartmouth College
    Inventor: Ruth W. Craig
  • Antibodies which specifically bind mcl-1 polypeptide
    Patent number: 5470955
    Abstract: A gene, mcl-1, of the bcl-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic methods of utilizing the mcl-1 nucleotide and polypeptide sequences. Antibodies which specifically bind the MCL-1 protein are also provided.
    Type: Grant
    Filed: June 16, 1993
    Date of Patent: November 28, 1995
    Assignee: Dartmouth College
    Inventor: Ruth W. Craig