Patents by Inventor Ruurdtje Hoekstra

Ruurdtje Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEPATIC CELL LINE RESISTANT TO DIMETHYL SULFOXIDE, CELL CULTURE AND USES THEREOF
    Publication number: 20190256822
    Abstract: The present invention relates to genetically modified HepaRG cells as deposited on Oct. 5, 2016 at the Leibniz-Institut DSMZ Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH, under No. DSM ACC3291. The invention further relates to methods of culturing said cells and cell cultures comprising said cells. The invention further relates to uses of the genetically modified HepaRG cells.
    Type: Application
    Filed: July 1, 2017
    Publication date: August 22, 2019
    Inventors: Vincent Alexander VAN DER MARK, Ruurdtje HOEKSTRA
  • DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS
    Publication number: 20150073389
    Abstract: Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of freshly isolated human hepatocytes. The hepatocyte cells and BAL systems can be used to treat patients suffering from acute liver failure, end-stage liver disease, or acute-on-chronic liver disease.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 12, 2015
    Applicant: Academisch Ziekenhuis Bij De Universiteit Van Amsterdam
    Inventors: Robert Antoine Francois Marie CHAMULEAU, Ruurdtje HOEKSTRA, Gerardus Adrianus Antonius NIBOURG
  • Differentiated human liver cell cultures and their use in bioartificial liver systems
    Patent number: 8921108
    Abstract: The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: December 30, 2014
    Assignee: Academisch Ziekenhuis Bij de Universiteit van Amsterdam
    Inventors: Robert Antoine François Marie Chamuleau, Ruurdtje Hoekstra, Gerardus Adrianus Antonius Nibourg
  • DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS
    Publication number: 20120111795
    Abstract: The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application.
    Type: Application
    Filed: April 21, 2010
    Publication date: May 10, 2012
    Applicant: ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM
    Inventors: Robert Antoine François Marie Chamuleau, Ruurdtje Hoekstra, Gerardus Adrianus Antonius Nibourg