Abstract: An online system accesses a machine learning model trained to predict behaviors of users of the online system, in which the model is trained based on historical data received by the online system that is associated with the users and demand and supply sides associated with the online system. The online system identifies a treatment for achieving a goal of the online system and simulates application of the treatment on the demand and supply sides based on the historical data and a set of behaviors predicted for the users. Application of the treatment is simulated by replaying the historical data in association with application of the treatment and applying the model to predict the set of behaviors while replaying the data. The online system measures an effect of application of the treatment on the demand and supply sides based on the simulation, in which the effect is associated with the goal.

Abstract: A tool changer at a distal end of a robotic arm may include a proximal engagement plate and a tool may include a distal engagement plate magnetically engaged with the proximal engagement plate. The tool changer may be configured to magnetically engage and disengage with a variety of tools as different tools are needed for operations being performed by the robotic arm. Decisions regarding which tools to couple to the tool changer may be made on-the-fly and based on changing circumstances as the robotic arm is used to operate on objects.

Abstract: Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

Abstract: A rapid screening method for identifying acylfulvenes and acylfulvene analogs with improved chemotherapeutic properties has been developed. The mechanism of toxicity of irofulven, a potentially clinically useful member of the acylfulvene class, has been elucidated and provides guidance for design and testing of a new class of alkylating agents with structures related to irofulven. The role of alkenal/one oxidoreductase (AOR) is shown to be important in cancer cell susceptibility to this class of alkylating agent.

Abstract: A rapid screening method for identifying acylfulvenes and acylfulvene analogs with improved chemotherapeutic properties has been developed. The mechanism of toxicity of irofulven, a potentially clinically useful member of the acylfulvene class, has been elucidated and provides guidance for design and testing of a new class of alkylating agents with structures related to irofulven. The role of alkenal/one oxidoreductase (AOR) is shown to be important in cancer cell susceptibility to this class of alkylating agent.