Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: An image intensifier device and a method of fabricating the image intensifier device are disclosed. The image intensifier device includes a microchannel plate (MCP) having a thin-film applied to a surface thereof. An anode assembly comprising an image sensor mounted to a header is positioned adjacent the MCP. A spacer defining a mounting surface is positioned against a mounting surface of the header of the anode assembly for separating the MCP from the anode assembly. A recess is defined in either the header or the spacer at the interface between the header and the spacer. The recess forms a passageway defined between the spacer and the header thru which organic gases pass.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: The present invention is directed to a tool and apparatus for forming a moldable material into a formed product having a desired shape, and optionally having a pouch for inserting pills, vitamins, and the like. The tool comprises a sleeve with a concentric insert, with a gap between the two for directing compressed air to eject the formed product from the tool. Exemplary apparatus using the tool and an associated method are also provided.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1, W, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: A system and method are provided for controlling the temperature of engine bleed air from a turbofan gas turbine engine. The system includes a fan air valve and a fan air valve controller. The fan air valve is adapted to receive a flow of fan air from a turbofan gas turbine engine intake fan. The fan air valve is coupled to receive valve position commands and is configured, in response to the valve position commands, to move to a valve position to thereby control the engine bleed air temperature. The fan air valve controller is configured to implement a linear quadratic regulator (LQR) control. The fan air valve controller is adapted to receive a plurality of sensor signals, each sensor signal representative of one or more system parameters, and is configured, in response to the sensor signals, to supply the valve position commands to the fan air valve.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: An image intensifier device and a method of fabricating the image intensifier device are disclosed. The image intensifier device includes a microchannel plate (MCP) having a thin-film applied to a surface thereof. An anode assembly comprising an image sensor mounted to a header is positioned adjacent the MCP. A spacer defining a mounting surface is positioned against a mounting surface of the header of the anode assembly for separating the MCP from the anode assembly. A recess is defined in either the header or the spacer at the interface between the header and the spacer. The recess forms a passageway defined between the spacer and the header thru which organic gases pass.

Abstract: A sealing structure for an optical device, such as an image intensifier device, is provided. The optical device includes an evacuated housing and an anode positioned within the evacuated housing. An interior sealing member extends from the anode. An exterior sealing member extends from a component of the image intensifier device, wherein the exterior sealing member is positioned to extend adjacent to and substantially parallel with the interior sealing member such that a gap is defined between the sealing members. A seal cup is positioned for sealing engagement with both the interior sealing member and the exterior sealing member to substantially maintain a vacuum condition within the housing.

Abstract: A microchannel plate (MCP) for an image intensifier includes an active portion having an input surface area for receiving electrons and an output surface area for outputting multiplied electrons. The input and output surface areas are oriented horizontally with respect to each other and spaced by a vertical distance. A non-active portion surrounds the active portion of the MCP. The non-active portion includes at least one slot extending vertically into the non-active portion and extending horizontally to form a horizontal slotted area. When the MCP is positioned vertically above an electron sensing device having wires looping vertically above the electron sensing device, the slot is configured to receive a portion of the wires, resulting in a vertical clearance between the MCP and the electron sensing device. The wires loop a vertical looping distance above a surface of the electron sensing device, and a portion of the vertical looping distance is configured to be received within the slot of the MCP.

Abstract: A microchannel plate (MCP) for an image intensifier includes an active portion having an input surface area for receiving electrons and an output surface area for outputting multiplied electrons. The input and output surface areas are oriented horizontally with respect to each other and spaced by a vertical distance. A non-active portion surrounds the active portion of the MCP. The non-active portion includes at least one slot extending vertically into the non-active portion and extending horizontally to form a horizontal slotted area. When the MCP is positioned vertically above an electron sensing device having wires looping vertically above the electron sensing device, the slot is configured to receive a portion of the wires, resulting in a vertical clearance between the MCP and the electron sensing device. The wires loop a vertical looping distance above a surface of the electron sensing device, and a portion of the vertical looping distance is configured to be received within the slot of the MCP.

Abstract: The present invention is directed to a tool and apparatus for forming a moldable material into a formed product having a desired shape, and optionally having a pouch for inserting pills, vitamins, and the like. The tool comprises a sleeve with a concentric insert, with a gap between the two for directing compressed air to eject the formed product from the tool. Exemplary apparatus using the tool and an associated method are also provided.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1, W, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: A fishing rod securing device includes a housing where the housing has a first end for securing the fishing rod to a structure and a second end for coupling to a fishing rod. The first end has a passage at which the structure can be received. Also, the housing provides a biased element where the biased element detachably clamps the structure in the structure passage.

Abstract: The system initiates a search at a first network site for user-specified data in a remote database at a second network site and conducts the search at a third network site (e.g., at a host computer's site). To begin, the system receives, at the first network site, a provider identifier associated with the database from the second network site. Thereafter, the user-specified data is input at the first network site, following which the user-specified data and the provider identifier are output from the first network site to the third network site. The system then searches for the user-specified data in a database at the third network site using the provider identifier. This database at the third network site includes data that corresponds to data stored in the remote database at the second network site.

Abstract: The system initiates a search at a first network site for user-specified data in a remote database at a second network site and conducts the search at a third network site (e.g., at a host computer's site). To begin, the system receives, at the first network site, a provider identifier associated with the database from the second network site. Thereafter, the user-specified data is input at the first network site, following which the user-specified data and the provider identifier are output from the first network site to the third network site. The system then searches for the user-specified data in a database at the third network site using the provider identifier. This database at the third network site includes data that corresponds to data stored in the remote database at the second network site.