Patents by Inventor Ryan C. Bailey
Ryan C. Bailey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240142445Abstract: Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. In several embodiments, systems and methods further include a particle attached to the antibody or capable of binding to the antibody. In several embodiments, systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in real-time.Type: ApplicationFiled: September 6, 2023Publication date: May 2, 2024Inventors: Ryan C. Bailey, Abraham J. Qavi, Jared T. Kindt, Ji-Yeon Byeon, Matthew S. Luchansky, Melinda S. McClellan, Adam L. Washburn, Tate Owen, Martin Anthony Gleeson, Lawrence C. Gunn
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Publication number: 20210140955Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.Type: ApplicationFiled: July 10, 2020Publication date: May 13, 2021Inventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
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Patent number: 10736992Abstract: The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.Type: GrantFiled: February 27, 2012Date of Patent: August 11, 2020Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Ryan C. Bailey, Brendan A. Harley, Teresa A. Martin, Steven R. Caliari
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Patent number: 10739340Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.Type: GrantFiled: April 27, 2018Date of Patent: August 11, 2020Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
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Patent number: 10514366Abstract: A liquid chromatograph comprising a column coupled to a microring resonator array and methods of using the same are disclosed. The microring resonator array measures the bulk refractive index of the mobile phase and any sample injected onto and separated in the column. While carrying out the methods, the composition of a mobile phase passing through the chromatography column may remain substantially constant (isocratic elution) or it may vary (gradient elution). One or more microrings may comprise a covering to act as a thermal control. In addition, the sensor surface may be modified with some type of capture agent that can interact with one or more components in the sample.Type: GrantFiled: September 3, 2015Date of Patent: December 24, 2019Assignee: The Board of Trustees of the University of IllinoisInventors: Ryan C. Bailey, James H. Wade
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Publication number: 20190192735Abstract: The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.Type: ApplicationFiled: February 27, 2012Publication date: June 27, 2019Inventors: Ryan C. Bailey, Brendan A. Harley, Teresa A. Martin, Steven R. Caliari
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Patent number: 10213782Abstract: In one representative embodiment, a device includes a main microchannel and at least two other microchannels. The main microchannel defines a main fluid flow path and has an opening, and first and second microchannels defining a first and second fluid flow paths, respectively. The first fluid flow path is in fluidic communication with the main fluid flow path via the opening and forms a first angle relative to the main microchannel less than 90 degrees. The second microchannel defines a second fluid flow path in fluidic communication with the main fluid flow path via the opening and in fluidic communication with the first fluid flow path. The second microchannel forms a second angle relative to the main microchannel less than 90 degrees. The first and second microchannels form a third angle relative to one another, with the third angle being between 60 and 135 degrees.Type: GrantFiled: March 2, 2016Date of Patent: February 26, 2019Assignee: The Board of Trustees of the University of IllinoisInventors: Ryan C. Bailey, Steven R. Doonan, Yi Xu
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Publication number: 20190003975Abstract: Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. In several embodiments, systems and methods further include a particle attached to the antibody or capable of binding to the antibody. In several embodiments, systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in real-time.Type: ApplicationFiled: March 19, 2018Publication date: January 3, 2019Inventors: Ryan C. Bailey, Abraham J. Qavi, Jared T. Kindt, Ji-Yeon Byeon, Matthew S. Luchansky, Melinda S. McClellan, Adam L. Washburn, Tate Owen, Martin Anthony Gleeson, Lawrence C. Gunn, III
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Publication number: 20180299438Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.Type: ApplicationFiled: April 27, 2018Publication date: October 18, 2018Inventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
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Patent number: 9983206Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.Type: GrantFiled: March 13, 2014Date of Patent: May 29, 2018Assignee: The Board of Trustees of the University of IllinoisInventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
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Patent number: 9921165Abstract: Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. In several embodiments, systems and methods further include a particle attached to the antibody or capable of binding to the antibody. In several embodiments, systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in real-time.Type: GrantFiled: November 4, 2011Date of Patent: March 20, 2018Assignees: Genalyte, Inc., The Board of Trustees of the University of IllinoisInventors: Ryan C. Bailey, Abraham J. Qavi, Jared T. Kindt, Ji-Yeon Byeon, Matthew S. Luchansky, Melinda S. McClellan, Adam L. Washburn, Tate Owen, Martin Anthony Gleeson, Lawrence C. Gunn, III
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Publication number: 20170248560Abstract: A liquid chromatograph comprising a column coupled to a microring resonator array and methods of using the same are disclosed. The microring resonator array measures the bulk refractive index of the mobile phase and any sample injected onto and separated in the column. While carrying out the methods, the composition of a mobile phase passing through the chromatography column may remain substantially constant (isocratic elution) or it may vary (gradient elution). One or more microrings may comprise a covering to act as a thermal control. In addition, the sensor surface may be modified with some type of capture agent that can interact with one or more components in the sample.Type: ApplicationFiled: September 3, 2015Publication date: August 31, 2017Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Ryan C. BAILEY, James H. WADE
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Publication number: 20160258902Abstract: In one representative embodiment, a device includes a main microchannel and at least two other microchannels. The main microchannel defines a main fluid flow path and has an opening, and first and second microchannels defining a first and second fluid flow paths, respectively. The first fluid flow path is in fluidic communication with the main fluid flow path via the opening and forms a first angle relative to the main microchannel less than 90 degrees. The second microchannel defines a second fluid flow path in fluidic communication with the main fluid flow path via the opening and in fluidic communication with the first fluid flow path. The second microchannel forms a second angle relative to the main microchannel less than 90 degrees. The first and second microchannels form a third angle relative to one another, with the third angle being between 60 and 135 degrees.Type: ApplicationFiled: March 2, 2016Publication date: September 8, 2016Applicant: The Board of Trustees of the University of IllinoisInventors: Ryan C. Bailey, Steven R. Doonan, Yi Xu
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Publication number: 20140273029Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: The Board of Trustees of the University of IllinoisInventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
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Publication number: 20130295688Abstract: Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. In several embodiments, systems and methods further include a particle attached to the antibody or capable of binding to the antibody. In several embodiments, systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in real-time.Type: ApplicationFiled: November 4, 2011Publication date: November 7, 2013Inventors: Ryan C. Bailey, Abraham J. Qavi, Jared T. Kindt, Ji-Yeon Byeon, Matthew S. Luchansky, Melinda S. McClellan, Adam L. Washburn, Tate Owen, Martin Anthony Gleeson, Lawrence C. Gunn, III
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Patent number: 8354231Abstract: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.Type: GrantFiled: January 4, 2010Date of Patent: January 15, 2013Assignee: Cal. Inst. Tech.Inventors: Gabriel A. Kwong, Ryan C. Bailey, Rong Fan, James R. Heath
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Publication number: 20110039717Abstract: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.Type: ApplicationFiled: January 4, 2010Publication date: February 17, 2011Inventors: Gabriel A. Kwong, Ryan C. Bailey, Rong Fan, James R. Heath
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Publication number: 20090017455Abstract: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded-protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.Type: ApplicationFiled: August 1, 2007Publication date: January 15, 2009Inventors: Gabriel A. Kwong, Ryan C. Bailey, Rong Fan, James R. Heath