Patents by Inventor Ryan Christopher Smith
Ryan Christopher Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230406874Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: ApplicationFiled: August 1, 2023Publication date: December 21, 2023Inventors: Frank J. Steemers, Kevin L. Gunderson, Kerri York, Ryan Christopher Smith
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Publication number: 20230357846Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: May 26, 2023Publication date: November 9, 2023Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 11760772Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: GrantFiled: May 26, 2021Date of Patent: September 19, 2023Assignee: Illumina, Inc.Inventors: Frank J. Steemers, Kevin L. Gunderson, Kerri York, Ryan Christopher Smith
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Patent number: 11702694Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: March 1, 2021Date of Patent: July 18, 2023Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Publication number: 20210277043Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: ApplicationFiled: May 26, 2021Publication date: September 9, 2021Applicant: Illumina, Inc.Inventors: Frank J. Steemers, Kevin L. Gunderson, Kerri York, Ryan Christopher Smith
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Publication number: 20210254151Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: March 1, 2021Publication date: August 19, 2021Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 11021504Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: GrantFiled: May 16, 2019Date of Patent: June 1, 2021Assignee: Illumina, Inc.Inventors: Frank J Steemers, Kevin L Gunderson, Kerri York, Ryan Christopher Smith
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Patent number: 10954561Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: April 10, 2019Date of Patent: March 23, 2021Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 10941635Abstract: An exemplary embodiment includes a system to determine which wells provide input volumes to gas processing plants using a mixed-integer programming (MIP) model. The system uses a balanced approach to model all plants and wells within a basin simultaneously. The model utilizes multiple publically available data sources including well production data, plant inlet data, and GIS data. The full implementation provides at minimum a tenfold time improvement over the previously used manual techniques while increasing overall model quality.Type: GrantFiled: June 27, 2016Date of Patent: March 9, 2021Assignee: EAST DALEY CAPITAL ADVISORS, INCInventors: Levi Austin DeLissa, Justin Henry Carlson, Ryan Christopher Smith
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Patent number: 10773264Abstract: An apparatus for coating glass articles includes a housing structure defining a chamber for receiving air or other fluid from a source of pressurized air that is in fluid communication with the chamber. The housing structure has an open end and a surface defined along at least a portion of the open end. A hot-swappable insert is removably positioned on the surface. The hot-swappable insert has a series of apertures for distributing the air or other fluid from the chamber and onto a surface of the glass articles that are positioned adjacent the insert. The insert can be replaced with another insert to adjust the flow path of the air or other fluid onto the glass articles.Type: GrantFiled: November 18, 2016Date of Patent: September 15, 2020Assignee: Arkema Inc.Inventors: Jeremy Jon Nihart, Ryan Christopher Smith, Jeffery Lee Stricker
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Publication number: 20190270764Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: ApplicationFiled: May 16, 2019Publication date: September 5, 2019Applicant: Illumina, Inc.Inventors: Frank J Steemers, Kevin L Gunderson, Kerri York, Ryan Christopher Smith
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Publication number: 20190233890Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 10294258Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: GrantFiled: February 13, 2017Date of Patent: May 21, 2019Assignee: Illumina, Inc.Inventors: Frank J. Steemers, Kevin L. Gunderson, Kerri York, Ryan Christopher Smith
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Publication number: 20180345301Abstract: An apparatus for coating glass articles includes a housing structure defining a chamber for receiving air or other fluid from a source of pressurized air that is in fluid communication with the chamber. The housing structure has an open end and a surface defined along at least a portion of the open end. A hot-swappable insert is removably positioned on the surface. The hot-swappable insert has a series of apertures for distributing the air or other fluid from the chamber and onto a surface of the glass articles that are positioned adjacent the insert. The insert can be replaced with another insert to adjust the flow path of the air or other fluid onto the glass articles.Type: ApplicationFiled: November 18, 2016Publication date: December 6, 2018Inventors: Jeremy Jon NIHART, Ryan Christopher SMITH, Jeffery Lee STRICKER
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Publication number: 20170253626Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: ApplicationFiled: February 13, 2017Publication date: September 7, 2017Inventors: Frank J. Steemers, Kevin L. Gunderson, Kerri York, Ryan Christopher Smith
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Patent number: 9598453Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: GrantFiled: May 20, 2015Date of Patent: March 21, 2017Assignee: ILLUMINA, INC.Inventors: Frank J. Steemers, Kevin Gunderson, Kerri York, Ryan Christopher Smith
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Patent number: 9475831Abstract: A compound has Formula I: A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, aryl, aldehyde, protected aldehyde, CH, N, O, S, null, and bond; Q is selected from aldehyde, protected aldehyde, and null, at least one of A, B, C, D, W, X, Y, Z, or Q is an aldehyde or protected aldehyde; the bonds between each of A-B, B-C, C-D, W-X, X-Y, and Y-Z are selected from single bond, double bond, triple bond, and no bond; L is a linker selected from a C1-C12 alkyl, aralkyl, and aryl, any of which is optionally substituted; one or more methylene unit (CH2) of the C1-C12 alkyl is optionally replaced by any combination of oxygen, carbonyl(C?O), and NH; and R1 and R2 are independently selected from —NR3R4, halogen, C1-C8 alkoxy, aralkoxy, alkenyloxy, alkynyloxy, and OCH2CH2CN; R3 and R4 are independently a C1-C4, straight chain or branched alkyl group.Type: GrantFiled: January 20, 2016Date of Patent: October 25, 2016Assignee: Illumina, Inc.Inventors: Ryan Christopher Smith, Randall Smith, Xiaodong Zhao
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Publication number: 20160137677Abstract: A compound has Formula I: A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, aryl, aldehyde, protected aldehyde, CH, N, O, S, null, and bond; Q is selected from aldehyde, protected aldehyde, and null, at least one of A, B, C, D, W, X, Y, Z, or Q is an aldehyde or protected aldehyde; the bonds between each of A-B, B-C, C-D, W-X, X-Y, and Y-Z are selected from single bond, double bond, triple bond, and no bond; L is a linker selected from a C1-C12 alkyl, aralkyl, and aryl, any of which is optionally substituted; one or more methylene unit (CH2) of the C1-C12 alkyl is optionally replaced by any combination of oxygen, carbonyl(C?O), and NH; and R1 and R2 are independently selected from —NR3R4, halogen, C1-C8 alkoxy, aralkoxy, alkenyloxy, alkynyloxy, and OCH2CH2CN; R3 and R4 are independently a C1-C4, straight chain or branched alkyl group.Type: ApplicationFiled: January 20, 2016Publication date: May 19, 2016Inventors: Ryan Christopher SMITH, Randall SMITH, Xiaodong ZHAO
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Patent number: 9273074Abstract: A compound has Formula I: A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, aryl, aldehyde, protected aldehyde, CH, N, O, S, null, and bond; Q is selected from aldehyde, protected aldehyde, and null, at least one of A, B, C, D, W, X, Y, Z, or Q is an aldehyde or protected aldehyde; the bonds between each of A-B, B-C, C-D, W-X, X-Y, and Y-Z are selected from single bond, double bond, triple bond, and no bond; L is a linker selected from a C1-C12 alkyl, aralkyl, and aryl, any of which is optionally substituted; one or more methylene unit (CH2) of the C1-C12 alkyl is optionally replaced by any combination of oxygen, carbonyl(C?O), and NH; and R1 and R2 are independently selected from —NR3R4, halogen, C1-C8 alkoxy, aralkoxy, alkenyloxy, alkynyloxy, and OCH2CH2CN; R3 and R4 are independently a C1-C4, straight chain or branched alkyl group.Type: GrantFiled: October 10, 2014Date of Patent: March 1, 2016Assignee: Illumina, Inc.Inventors: Ryan Christopher Smith, Randall Smith, Xiaodong Zhao
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Publication number: 20150353592Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.Type: ApplicationFiled: May 20, 2015Publication date: December 10, 2015Applicant: Illumina, Inc.Inventors: Frank J. Steemers, Kevin Gunderson, Kerri York, Ryan Christopher Smith