Patents by Inventor Ryan Coatsworth Holcomb

Ryan Coatsworth Holcomb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts
    Patent number: 8314108
    Abstract: The present invention provides an aminopyrazole compound, more particularly, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: November 20, 2012
    Assignee: Eli Lilly and Company
    Inventors: Francine S. Farouz, Ryan Coatsworth Holcomb, Ramesh Kasar, Steven Scott Myers
  • Heteroaryl urea derivatives useful for inhibiting CHK1
    Patent number: 8093244
    Abstract: Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: January 10, 2012
    Assignee: ICOS Corporation
    Inventors: Frank Diaz, Francine S. Farouz, Ryan Coatsworth Holcomb, Edward A. Kesicki, Kimba Lee Fischer, Adam Wade Cook
  • COMPOUNDS USEFUL FOR INHIBITING CHK1
    Publication number: 20110144126
    Abstract: The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 16, 2011
    Inventors: Francine S. Farouz, Ryan Coatsworth Holcomb, Ramesh Kasar, Steven Scott Myers
  • HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1
    Publication number: 20090143357
    Abstract: Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.
    Type: Application
    Filed: March 29, 2006
    Publication date: June 4, 2009
    Applicant: ICOS CORPORATION
    Inventors: Frank Diaz, Francine S. Farouz, Ryan Coatsworth Holcomb, Edward A. Kesicki, Hua Chee Ooi, Alexander Rudolph, Frank Stappenbeck, Eugene D. Thorsett, John Joseph Gaudino, Kimba Lee Fischer, Adam Wade Cook
  • Compounds Useful for Inhibiting Chk1
    Publication number: 20080318974
    Abstract: Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
    Type: Application
    Filed: August 18, 2005
    Publication date: December 25, 2008
    Applicant: Icos Corporation
    Inventors: John Joseph Gaudino, Francine S. Farouz, Ryan Coatsworth Holcomb, Eugene D. Thorsett