Patents by Inventor Ryan DeSousa
Ryan DeSousa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11793430Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more optical signal stabilizing additives in an environment of the sensor.Type: GrantFiled: October 1, 2020Date of Patent: October 24, 2023Assignee: Senseonics, IncorporatedInventors: Ryan DeSousa, Robert Atwood, Philip Huffstetler, Joon Chatterjee, Sanat Mohanty
-
Patent number: 11111327Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.Type: GrantFiled: January 17, 2019Date of Patent: September 7, 2021Assignee: Alcon Inc.Inventors: Ryan DeSousa, Troy Vernon Holland, Frank Chang
-
Publication number: 20210093235Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more optical signal stabilizing additives in an environment of the sensor.Type: ApplicationFiled: October 1, 2020Publication date: April 1, 2021Applicant: Senseonics, IncorporatedInventors: Ryan DeSousa, Robert Atwood, Philip Huffstetler, Joon Chatterjee, Sanat Mohanty
-
Patent number: 10906258Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.Type: GrantFiled: August 28, 2018Date of Patent: February 2, 2021Assignee: Alcon Inc.Inventors: Troy Vernon Holland, Frank Chang, Ryan DeSousa
-
Patent number: 10829574Abstract: The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.Type: GrantFiled: March 3, 2020Date of Patent: November 10, 2020Assignee: Alcon Inc.Inventors: Frank Chang, Troy Vernon Holland, Feng Jing, Ryan DeSousa
-
Patent number: 10823983Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.Type: GrantFiled: February 20, 2019Date of Patent: November 3, 2020Assignee: Alcon Inc.Inventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, John Dallas Pruitt, Jared Nelson
-
Publication number: 20200199269Abstract: The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.Type: ApplicationFiled: March 3, 2020Publication date: June 25, 2020Inventors: Frank Chang, Troy Vernon Holland, Feng Jing, Ryan DeSousa
-
Patent number: 10676557Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.Type: GrantFiled: January 23, 2019Date of Patent: June 9, 2020Assignee: Alcon Inc.Inventors: Frank Chang, Ryan DeSousa, Jinyu Huang
-
Patent number: 10618986Abstract: The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.Type: GrantFiled: October 12, 2017Date of Patent: April 14, 2020Assignee: Alcon Inc.Inventors: Frank Chang, Troy Vernon Holland, Feng Jing, Ryan DeSousa
-
Patent number: 10472319Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.Type: GrantFiled: May 2, 2019Date of Patent: November 12, 2019Assignee: Novartis AGInventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, Walter R. Laredo
-
Publication number: 20190256455Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.Type: ApplicationFiled: May 2, 2019Publication date: August 22, 2019Inventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, Walter R. Laredo
-
Publication number: 20190225726Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.Type: ApplicationFiled: January 17, 2019Publication date: July 25, 2019Inventors: Ryan DeSousa, Troy Vernon Holland, Frank Chang
-
Patent number: 10322993Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.Type: GrantFiled: November 15, 2016Date of Patent: June 18, 2019Assignee: Novartis AGInventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, Walter R. Laredo
-
Patent number: 10324311Abstract: Described herein are acyl germanium photoinitiator for cost-effective and time-efficient method for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a method for making UV-absorbing contact lenses made by using an acyl germanium photoinitiator of the invention.Type: GrantFiled: May 31, 2016Date of Patent: June 18, 2019Assignee: Novartis AGInventors: Troy Vernon Holland, Frank Chang, Ryan DeSousa
-
Publication number: 20190179170Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.Type: ApplicationFiled: February 20, 2019Publication date: June 13, 2019Inventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, John Dallas Pruitt, Jared Nelson
-
Publication number: 20190153141Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.Type: ApplicationFiled: January 23, 2019Publication date: May 23, 2019Inventors: Frank Chang, Ryan DeSousa, Jinyu Huang
-
Patent number: 10268053Abstract: Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.Type: GrantFiled: February 16, 2017Date of Patent: April 23, 2019Assignee: Novartis AGInventors: Troy Vernon Holland, Frank Chang, Walter R. Laredo, Xuwei Jiang, Ryan DeSousa
-
Patent number: 10254567Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.Type: GrantFiled: February 16, 2017Date of Patent: April 9, 2019Assignee: Novartis AGInventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, John Dallas Pruitt, Jared Nelson
-
Patent number: 10227435Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.Type: GrantFiled: December 13, 2016Date of Patent: March 12, 2019Assignee: Novartis AGInventors: Frank Chang, Ryan DeSousa, Jinyu Huang
-
Publication number: 20190061293Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.Type: ApplicationFiled: August 28, 2018Publication date: February 28, 2019Inventors: Troy Vernon Holland, Frank Chang, Ryan DeSousa