Abstract: A medical device, comprising a fastening assembly, wherein the fastening assembly includes an adapter defining an opening therethrough, a fastener releasably coupled to the adapter, wherein the fastener includes at least two jaws pivotable relative to one another, the fastener having a first configuration wherein the jaws are open and a second configuration wherein the jaws are closed, and at least one cable coupled to the fastener and the adapter, the at least one cable being configured to apply tension to the fastener to transition between the first configuration and the second configuration while the fastener is coupled to the adapter, and to control release of the fastener from the adapter.

Abstract: A valve assembly for a medical device including a container including a first region and a second region, a first fluid inlet fluidly coupled to the first region, a second fluid inlet fluidly coupled to the second region, and a piston assembly disposed within the container. The container is configured to house an agent within the second region, the first fluid inlet is configured to deliver a first portion of pressurized fluid to the first region at a first pressure level, and the second fluid inlet is configured to deliver a second portion of pressurized fluid to the second region at a second pressure level that is less than the first pressure level. The piston assembly includes a valve configured to move from a first position to a second position in response to the piston assembly moving relative to the container.

Abstract: Variable temperature analytical instruments are provided that can include: a mobile component comprising a cold source; a substantially fixed analysis component; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a mobile analysis component; a substantially fixed component comprising a cold source; and an interface configured to couple the mobile component with the analysis component. Variable temperature analytical instruments are also provided that can include: a cold source in thermal communication with an analysis component; and at least one pressure barrier defining a plurality of discrete masses maintained at different temperatures between the cold source and the analysis component.

Abstract: A closure device includes a first ring structure having a first distal portion and a first medial portion and a second ring structure having a second distal portion and a second medial portion. The first and second distal portions are movable between an open position, where the first and second distal portions form an angle relative to one another for receiving target tissue therebetween, and a closed position, where the first and second distal portions are drawn toward one another for gripping the target tissue. The device also includes an anvil about which the first and second medial portions are formed. Either one of proximal motion of the anvil relative to the first and second rings or proximal motion of the medial portions relative to the anvil causes the first and second distal portions to move into either one of the open position or the closed position.

Abstract: A valve assembly for a medical device that includes a body having an inlet that is in fluid communication with a source of fluid, and an outlet that is in fluid communication with a delivery conduit of the medical device. The valve assembly includes a shuttle configured to move within the body between a first and second position to control delivery of fluid from the inlet to the outlet. In the first position, the shuttle is configured to maintain the fluid at a first pressure within the body and seal the outlet from the inlet, such that the delivery conduit is isolated from the fluid at the first pressure. In the second position, the shuttle is configured to maintain the fluid at a second pressure within the body and fluidly couple the outlet to the inlet, such that the delivery conduit receives the fluid at the second pressure.

Abstract: A closure device includes a first ring structure having a first distal portion and a first medial portion and a second ring structure having a second distal portion and a second medial portion. The first and second distal portions are movable between an open position, where the first and second distal portions form an angle relative to one another for receiving target tissue therebetween, and a closed position, where the first and second distal portions are drawn toward one another for gripping the target tissue. The device also includes an anvil about which the first and second medial portions are formed. Either one of proximal motion of the anvil relative to the first and second rings or proximal motion of the medial portions relative to the anvil causes the first and second distal portions to move into either one of the open position or the closed position.

Abstract: A medical device may comprise a handle portion; an insertion portion having a proximal end portion at the handle portion, wherein the insertion portion includes a lumen therein and a distal end having a distal opening in communication with the lumen; and a member disposed within the lumen, the member having a distal end portion with an imaging device. The member may be configured to transition between a first configuration and a second configuration. In the first configuration, the imaging device may face distally, and, in the second configuration, the imaging device may face proximally. Extending the distal end portion of the member distally past the distal opening may cause the member to transition from the first configuration to the second configuration.

Abstract: A medical device may comprise a handle portion; an insertion portion having a proximal end portion at the handle portion, wherein the insertion portion includes a lumen therein and a distal end having a distal opening in communication with the lumen; and a member disposed within the lumen, the member having a distal end portion with an imaging device. The member may be configured to transition between a first configuration and a second configuration. In the first configuration, the imaging device may face distally, and, in the second configuration, the imaging device may face proximally. Extending the distal end portion of the member distally past the distal opening may cause the member to transition from the first configuration to the second configuration.

Abstract: An example medical device is disclosed. The example medical device includes a shaft having a proximal end region, a distal end region and an outer surface. The medical device also includes a hemostasis clip coupled to the outer surface of the distal end region of the shaft, wherein the hemostasis clip is configured to shift between an open position and a closed position. Further, the medical device includes a tension member coupled to the hemostasis clip, wherein actuation of the tension member shifts the hemostasis clip between the open position and the closed position.

Abstract: A medical device, comprising a fastening assembly, wherein the fastening assembly includes an adapter defining an opening therethrough, a fastener releasably coupled to the adapter, wherein the fastener includes at least two jaws pivotable relative to one another, the fastener having a first configuration wherein the jaws are open and a second configuration wherein the jaws are closed, and at least one cable coupled to the fastener and the adapter, the at least one cable being configured to apply tension to the fastener to transition between the first configuration and the second configuration while the fastener is coupled to the adapter, and to control release of the fastener from the adapter.

Abstract: A closure device includes a first ring structure having a first distal portion and a first medial portion and a second ring structure having a second distal portion and a second medial portion. The first and second distal portions are movable between an open position, where the first and second distal portions form an angle relative to one another for receiving target tissue therebetween, and a closed position, where the first and second distal portions are drawn toward one another for gripping the target tissue. The device also includes an anvil about which the first and second medial portions are formed. Either one of proximal motion of the anvil relative to the first and second rings or proximal motion of the medial portions relative to the anvil causes the first and second distal portions to move into either one of the open position or the closed position.

Abstract: A medical device for delivering a material using a pressurized fluid includes an enclosure having a first chamber and a second chamber separated by a membrane, and an outlet, and a pin configured to move within the enclosure between a first position and a second position, where a proximal end of the pin blocks the outlet when the pin is in the first position.

Abstract: A device for delivering pressurized fluid includes a handle having a lumen configured to receive a container of pressurized fluid, a cap to close the lumen and an indicator to move from a first position to a second position. The first position indicates disconnection of the container from a fluid path, and the second position indicates connection of the container to the fluid path.

Abstract: A device configured to deliver a pressurized fluid includes a body having an input opening for receiving the pressurized fluid and an output opening for delivering the pressurized fluid, a handle defining a lumen, wherein the lumen is configured to receive a container containing the pressurized fluid, and at least one aperture fluidly connecting the lumen to an atmosphere external of the device.

Abstract: A medical system includes a handle having (1) a handle chamber including an outlet and (2) a barrel extending into the handle chamber and defining a lumen having a longitudinal axis, and a spindle movably disposed within the lumen of the barrel, the spindle including a plurality of spindle enclosures, and wherein the spindle is configured to move between a first configuration, in which at least a portion of each of the plurality of spindle enclosures is positioned within a first portion of the lumen within the handle chamber, and a second configuration, in which at least the portion of each of the plurality of spindle enclosures is positioned in a second portion of the lumen outside the handle chamber.

Abstract: A device for delivering an agent may comprise: a housing defining an enclosure. The housing may be configured to store an agent. The device may further comprise an inlet, in fluid communication with the enclosure, for receiving a flow of pressurized fluid; an outlet in fluid communication with the enclosure; and a filter disposed within the enclosure. Pores of a wall of the filter may be configured such that the fluid is permitted to pass through the pores into a channel defined by an inner surface of the wall. An actuation member may be configured to transition between a first configuration, in which portions of the agent disposed proximally to the actuation member are prevented from passing distally of the actuation member, and a second configuration, in which portions of the agent disposed proximally of the actuation member are capable of passing distally of the actuation member.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, in which distal ends of the clip arms extend distally past the distal end of the capsule to be separated from one another, and a closed configuration, in which the clip arms are restrained via an interior surface of the capsule so that distal ends of the clips arms are drawn toward one another, and a reinforcement element coupled to the clip arms, the reinforcement element preventing deflection of the clip arms when engaging a target tissue.

Abstract: A medical device may comprise a handle portion; an insertion portion having a proximal end portion at the handle portion, wherein the insertion portion includes a lumen therein and a distal end having a distal opening in communication with the lumen; and a member disposed within the lumen, the member having a distal end portion with an imaging device. The member may be configured to transition between a first configuration and a second configuration. In the first configuration, the imaging device may face distally, and, in the second configuration, the imaging device may face proximally. Extending the distal end portion of the member distally past the distal opening may cause the member to transition from the first configuration to the second configuration.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, in which distal ends of the clip arms extend distally past the distal end of the capsule to be separated from one another, and a closed configuration, in which the clip arms are restrained via an interior surface of the capsule so that distal ends of the clips arms are drawn toward one another, and a reinforcement element coupled to the clip arms, the reinforcement element preventing deflection of the clip arms when engaging a target tissue.

Abstract: An internal combustion engine includes a block defining at least one combustion cylinder. An intake manifold is fluidly coupled with at least one combustion cylinder, and an exhaust manifold is also fluidly coupled with at least one combustion cylinder. An exhaust gas recirculation system is fluidly coupled between the exhaust manifold and the intake manifold. A turbocharger includes a variable geometry turbine fluidly coupled with the exhaust manifold. The variable geometry turbine is movable to a first position effecting fluid flow of exhaust gas from the exhaust manifold to the intake manifold, and movable to a second position effecting fluid flow of charge air to the variable geometry turbine.