Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: According to one aspect, a power storage system may include an enclosure, and one or more modules disposed in the enclosure. Each of the one or more modules may include a plurality of electrochemical cells electrically coupled to one another, each one of the plurality of electrochemical cells including an oxygen evolution electrode (OEE), an anode, a gas diffusion electrode (GDE), an electrolyte, and a vessel and, within the vessel, the OEE, the anode, and the GDE at least partially immersed in the electrolyte.

Abstract: According to an aspect, an electrochemical cell may include a vessel, at least two instances of an anode assembly, at least two instances of an oxygen evolution electrode (OEE), and a gas diffusion electrode (GDE). In the vessel, the GDE may be disposed between mirrored arrangements of the at least two instances of the OEE and the at least two instances of the anode assembly.

Abstract: A method, computer program product, and computer system for defining, at a computing device, psychometric data for a user. An interactive virtual assistant, selected from a plurality of interactive virtual assistants, may be provided on the computing device based upon, at least in part, the psychometric data defined for the user. The user may be prompted, via the interactive virtual assistant, with one or more options.

Abstract: A method, computer program product, and computer system for defining, at a computing device, psychometric data for a user. An interactive virtual assistant, selected from a plurality of interactive virtual assistants, may be provided on the computing device based upon, at least in part, the psychometric data defined for the user. The user may be prompted, via the interactive virtual assistant, with one or more options.

Abstract: A user interface for a thermostat that controls a radiator valve can include a user input member that is movable from a home position to a set point increase or decrease position to increase or decrease a set point temperature of the thermostat. In some embodiments, a return mechanism returns the user input member to the home position after being released from one of the set point increase and decrease positions. The user interface can include an indicator panel and controller that controls the indicator panel to provide an indication of when the set point temperature of the thermostat is being adjusted. The user interface can also include a lockout controller that prevents further set point temperature adjustments using the user interface when the set point temperature differs from the environmental temperature by a specified amount.

Abstract: Systems and methods provide dynamically modifiable parameters in required time of arrival (RTA) speed regions of an assigned flight path of an aircraft. The system includes a vertical situation display (VSD) rendering thereon a vertical flight profile of the assigned flight path. A control module is coupled to the display system and configured to: demark the vertical flight profile with a plurality of RTA speed regions related to an initial speed profile; render an RTA speed band graphic having demarked sections vertically representing a speed minimum and speed maximum for an respective RTA speed region, the RTA speed band graphic representing a normalized speed range between zero and a maximum value for each respective RTA speed region. The control module accepts user modifications and updates the RTA speed band graphic and the current speed profile to reflect user input.

Abstract: A method, computer program product, and computer system for defining, at a computing device, psychometric data for a user. An interactive virtual assistant, selected from a plurality of interactive virtual assistants, may be provided on the computing device based upon, at least in part, the psychometric data defined for the user. The user may be prompted, via the interactive virtual assistant, with one or more options.

Abstract: Systems and methods provide dynamically modifiable parameters in required time of arrival (RTA) speed regions of an assigned flight path of an aircraft. The system includes a vertical situation display (VSD) rendering thereon a vertical flight profile of the assigned flight path. A control module is coupled to the display system and configured to: demark the vertical flight profile with a plurality of RTA speed regions related to an initial speed profile; render an RTA speed band graphic having demarked sections vertically representing a speed minimum and speed maximum for an respective RTA speed region, the RTA speed band graphic representing a normalized speed range between zero and a maximum value for each respective RTA speed region. The control module accepts user modifications and updates the RTA speed band graphic and the current speed profile to reflect user input.

Abstract: A heating fluid control system determines the aggregated demand for heating fluid from a plurality of sources of demand in a building and deactivates a boiler that provides the heating fluid when the aggregated demand is zero. The sources of demand can include radiators and domestic hot water fixtures. Valves that control the flow of heating fluid from the boiler to these sources of demand can transmit signals representative of the position of the valve. A controller can use these signals and other signals to determine the demand for heating fluid from each source of demand. The controller evaluates the signals to determine the aggregate system demand. And after deactivating the boiler, the controller can reactivate the boiler when the aggregate system demand is determined to be non-zero. Methods of using such heating systems are also disclosed.

Abstract: A user interface for a thermostat that controls a radiator valve can include a user input member that is movable from a home position to a set point increase or decrease position to increase or decrease a set point temperature of the thermostat. In some embodiments, a return mechanism returns the user input member to the home position after being released from one of the set point increase and decrease positions. The user interface can include an indicator panel and controller that controls the indicator panel to provide an indication of when the set point temperature of the thermostat is being adjusted. The user interface can also include a lockout controller that prevents further set point temperature adjustments using the user interface when the set point temperature differs from the environmental temperature by a specified amount.

Abstract: A user interface for a thermostat that controls a radiator valve can include a user input member that is movable from a home position to a set point increase or decrease position to increase or decrease a set point temperature of the thermostat. In some embodiments, a return mechanism returns the user input member to the home position after being released from one of the set point increase and decrease positions. The user interface can include an indicator panel and controller that controls the indicator panel to provide an indication of when the set point temperature of the thermostat is being adjusted. The user interface can also include a lockout controller that prevents further set point temperature adjustments using the user interface when the set point temperature differs from the environmental temperature by a specified amount.

Abstract: A heating system and method of using such system in a building for zoned radiant heating. The system includes thermostatic radiator valves, each fluidly connected between at least one radiator in a zone of the building and a boiler. A controller is operatively connected to the valves to deactivate the valve positioners when the controller determines that valve activity is likely to have little to no effect on the output of the respective radiator and/or active heating of the building is not desired. For example, the controller determines when the boiler is deactivated and sends a deactivation control signal to the valves operative to prevent the valve positioners from adjusting the respective valve position. In another example, the controller sends the deactivation control signals to the valves at the onset of preprogrammed low usage periods of the heating system.

Abstract: A method, computer program product, and computer system for defining, at a computing device, psychometric data for a user. An interactive virtual assistant, selected from a plurality of interactive virtual assistants, may be provided on the computing device based upon, at least in part, the psychometric data defined for the user. The user may be prompted, via the interactive virtual assistant, with one or more options.

Abstract: A method, computer program product, and computer system for defining, at a computing device, psychometric data for a user. An interactive virtual assistant, selected from a plurality of interactive virtual assistants, may be provided on the computing device based upon, at least in part, the psychometric data defined for the user. The user may be prompted, via the interactive virtual assistant, with one or more options.

Abstract: A user interface for a thermostat that controls a radiator valve can include a user input member that is movable from a home position to a set point increase or decrease position to increase or decrease a set point temperature of the thermostat. In some embodiments, a return mechanism returns the user input member to the home position after being released from one of the set point increase and decrease positions. The user interface can include an indicator panel and controller that controls the indicator panel to provide an indication of when the set point temperature of the thermostat is being adjusted. The user interface can also include a lockout controller that prevents further set point temperature adjustments using the user interface when the set point temperature differs from the environmental temperature by a specified amount.

Abstract: A heating fluid control system determines the aggregated demand for heating fluid from a plurality of sources of demand in a building and deactivates a boiler that provides the heating fluid when the aggregated demand is zero. The sources of demand can include radiators and domestic hot water fixtures. Valves that control the flow of heating fluid from the boiler to these sources of demand can transmit signals representative of the position of the valve. A controller can use these signals and other signals to determine the demand for heating fluid from each source of demand. The controller evaluates the signals to determine the aggregate system demand. And after deactivating the boiler, the controller can reactivate the boiler when the aggregate system demand is determined to be non-zero. Methods of using such heating systems are also disclosed.

Abstract: A heating system used in a building includes thermostatic radiator valves, each fluidly connected between at least one radiator in a zone of the building and a boiler. A controller is operatively connected to the valves to deactivate the valve positioners when the controller determines that valve activity is likely to have little to no effect on the output of the respective radiator and/or active heating of the building is not desired. For example, the controller determines when the boiler is deactivated and sends a deactivation control signal to the valves operative to prevent the valve positioners are prevented from adjusting the respective valve position. In another example, the controller sends the deactivation control signals to the valves at the onset of preprogrammed low usage periods of the heating system. Methods of using such heating systems are also disclosed.

Abstract: A method is provided for controlling speed of a vehicle. The method includes determining an arrival time error (ATE) for a required time of arrival (RTA) and a projected trajectory according to a travel plan with a current speed profile having a plurality of regions, each with a respective speed adjustment parameter (SAP) and a respective SAP value relative to a nominal speed profile. The method further includes selecting, when the ATE is greater than a threshold, one of the regions as a selected region for modification based on a priority order of the regions. The method further includes modifying the current speed profile by adjusting the respective SAP value for the selected region according to the respective SAP in order to decrease the ATE; and implementing the modified speed profile.