Patents by Inventor Ryan Jay Wenzel

Ryan Jay Wenzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Direct mass spectrometric analysis of drug candidates targeting protein complexes
    Patent number: 8097427
    Abstract: The invention relates to a method of using high mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the qualitative and quantitative analysis of the effect of drug candidates on protein complexes such as protein-protein interactions in purified samples or complex biological matrices, as well as to the use of this method for lead compound optimization, drug characterization, drug manufacturing processes, and drug quality control processes, including automated high throughput applications.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: January 17, 2012
    Assignee: CovalX AG
    Inventors: Alexis Txomin Nazabal, Ryan Jay Wenzel
  • Direct mass spectrometric analysis of aggregates of therapeutic proteins
    Patent number: 7943387
    Abstract: The invention relates to a method of using high-mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the quantitative analysis of the amount of aggregation (dimers, trimers or multimers) of antibodies or other therapeutic proteins in purified pharmaceutical samples or complex biological matrices, as well as to the use of this method for characterization of antibodies, drug development and quality control of therapeutic proteins, including automated high throughput applications.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: May 17, 2011
    Assignee: Covalx AG
    Inventors: Alexis Nazabal, Ryan Jay Wenzel
  • DIRECT MASS SPECTROMETRIC ANALYSIS OF DRUG CANDIDATES TARGETING PROTEIN COMPLEXES
    Publication number: 20100099200
    Abstract: The invention relates to a method of using high mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the qualitative and quantitative analysis of the effect of drug candidates on protein complexes such as protein-protein interactions in purified samples or complex biological matrices, as well as to the use of this method for lead compound optimization, drug characterization, drug manufacturing processes, and drug quality control processes, including automated high throughput applications.
    Type: Application
    Filed: March 14, 2008
    Publication date: April 22, 2010
    Inventors: Alexis Nazabal, Ryan Jay Wenzel