Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The systems and methods herein are configured to measure and display forces acting upon the therapy treatment head during a procedure. In some aspects, buoyancy forces from the acoustic coupling medium are also accounted for.

Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: An electric drive axle of a vehicle includes an electric motor having an output shaft. An idler assembly is drivingly coupled to the electric motor and a differential. The idler assembly includes a first gear-clutch assembly to facilitate a first gear ratio and a second gear-clutch assembly to facilitate a second gear ratio.

Abstract: A ballistic-resistant garment having a tensioning fastening system, and methods of making and using such a ballistic-resistant garment, whereby the ballistic-resistant garment includes (i) a front panel having a front panel pocket configured to receive a first ballistic-resistant insert; (ii) a back panel having a back panel pocket configured to receive a second ballistic-resistant insert; (iii) a front panel elastic elongate member coupled to the front panel; (iv) a front panel first fastener coupled to a front panel elastic elongate member first end; (v) a front panel second fastener coupled to a front panel elastic elongate member second end; (vi) a back panel elastic elongate member coupled to the back panel; (vii) a back panel first fastener coupled to a back panel elastic elongate member first end; and (viii) a back panel second fastener coupled to a back panel elastic elongate member second end.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: A ballistic-resistant garment having a tensioning fastening system, and methods of making and using such a ballistic-resistant garment, whereby the ballistic-resistant garment includes (i) a front panel having a front panel pocket configured to receive a first ballistic-resistant insert; (ii) a back panel having a back panel pocket configured to receive a second ballistic-resistant insert; (iii) a front panel elastic elongate member coupled to the front panel; (iv) a front panel first fastener coupled to a front panel elastic elongate member first end; (v) a front panel second fastener coupled to a front panel elastic elongate member second end; (vi) a back panel elastic elongate member coupled to the back panel; (vii) a back panel first fastener coupled to a back panel elastic elongate member first end; and (viii) a back panel second fastener coupled to a back panel elastic elongate member second end.

Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.

Abstract: A ballistic-resistant garment having an incrementally-adjustable fit, and methods of making and using such a ballistic-resistant garment, whereby the ballistic-resistant garment includes a front panel having a front panel pocket configured to receive a first ballistic-resistant insert; a back panel having a back panel pocket configured to receive a second ballistic-resistant insert; a front panel first fastener coupled to the front panel; and a plurality of discrete back panel first fasteners coupled in spaced apart relation to the back panel, whereby each of the discrete back panel first fasteners is configured to matably engage with the front panel first fastener to provide a first pair of releasably engaged fasteners which couple the front and back panels to fasten the ballistic-resistant garment about a torso of a wearer.

Abstract: A coupling portion of a wearable medical monitor may include an attachment member configured to reversibly couple the coupling portion to a body portion of the wearable medical monitor. The wearable medical monitor may be coupled to a sensor via a cable. The coupling portion may also include a cable retention feature including a channel configured to receive the cable. The cable retention feature may be configured to apply a retaining force to the cable when the cable is disposed in the channel.

Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.

Abstract: A coupling portion of a wearable medical monitor may include an attachment member configured to reversibly couple the coupling portion to a body portion of the wearable medical monitor. The wearable medical monitor may be coupled to a sensor via a cable. The coupling portion may also include a cable retention feature including a channel configured to receive the cable. The cable retention feature may be configured to apply a retaining force to the cable when the cable is disposed in the channel.

Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.