Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: This disclosure relates to methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen such as HER2, and pharmaceutical compositions thereof. Also provided are uses of the multi-specific binding protein in combination with an anti-PD-1 therapeutic and/or cytoskeletal disrupting chemotherapeutic agent.

Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting EGFR on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

Abstract: The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens for such heterodimeric Fc-fused proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.

Abstract: Systems and methods operate to infer a fuel composition in a combustion system. The fuel composition may be inferred by receiving measured operating parameters including one or more of fuel data defining fuel characteristics used in combustion within a heater of the combustion system, emissions data defining emission gasses exiting the heater, airflow data defining ambient air being supplied to the heater and airflow rate of the air within the heater. One or more relationships within the measured operating parameters may be identified that result in a list of potential fuel compositions. One of the potential fuel compositions from the list may be selected having sufficient likelihood of resulting in the measured operating parameters as an inferred fuel composition. The output the inferred fuel composition to a heater controller of the combustion system and used for automatic control thereof.

Abstract: Described herein are multispecific binding proteins that bind NKG2D receptor, CD 16, and EGFR, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.

Abstract: Described herein are pharmaceutical formulations comprising multi-specific binding proteins that bind to NKG2D, CD16, and epidermal growth factor receptor (EGFR); and therapeutic uses of the multi-specific binding proteins and pharmaceutical formulations thereof for treating a disease, for example, cancer, in a patient in need thereof.

Abstract: Combustion heater control systems and methods that include dynamic safety settings. Current operating parameters of the combustion heater are sensed at a plurality of time intervals and converted into a time-varying signal. The time-varying signal is compared to a burner stability envelope indicating when a burner is likely to enter an unstable state. The unstable state may include huffing, flashback, and/or liftoff. When the burner is likely to enter an unstable state, the combustion heater is controlled to prevent the unstable state.

Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting 5T4 on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and 5T4 are described, as well as pharmaceutical compositions, formulations, and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer.

Abstract: This disclosure relates to methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen such as HER2. Provided are uses of the multi-specific binding protein in combination with a corticosteroid to reduce the risk of infusion-related reactions. Also provided are uses of the multi-specific binding protein in treating cancer that has low or moderate HER2 expression level. The present disclosure also relates to pharmaceutical formulations comprising the multi-specific binding proteins.

Abstract: The invention provides antibodies that specifically bind to Plasminogen Activator inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

Abstract: A cardiopulmonary resuscitation (CPR) cerebral monitoring device including a measurement probe having one or more optical emitters, and one or more optical detectors, and including an optical instrument having an optical source, and an optical detector. Also included is a controller configured to control the optical instrument to emit multi-spectral light through the one or more optical emitters to illuminate a tissue, control the optical detector to detect multi-spectral light emitted from the illuminated tissue, compare the emitted multi-spectral light to the detected multi-spectral light, compute a plurality of cerebral tissue parameters based on the comparison, determine CPR procedures based on the plurality of cerebral tissue parameters, and control a user output device to instruct a user to perform the CPR procedures, and/or control an automated CPR device to perform the CPR procedures.

Abstract: Combustion heater control systems and methods that include dynamic safety settings. Current operating parameters of the combustion heater are sensed at a plurality of time intervals and converted into a time-varying signal. The time-varying signal is compared to a burner stability envelope indicating when a burner is likely to enter an unstable state. The unstable state may include huffing, flashback, and/or liftoff. When the burner is likely to enter an unstable state, the combustion heater is controlled to prevent the unstable state.

Abstract: Systems and methods operate to infer a fuel composition in a combustion system. The fuel composition may be inferred by receiving measured operating parameters including one or more of fuel data defining fuel characteristics used in combustion within a heater of the combustion system, emissions data defining emission gasses exiting the heater, airflow data defining ambient air being supplied to the heater and airflow rate of the air within the heater. One or more relationships within the measured operating parameters may be identified that result in a list of potential fuel compositions. One of the potential fuel compositions from the list may be selected having sufficient likelihood of resulting in the measured operating parameters as an inferred fuel composition. The output the inferred fuel composition to a heater controller of the combustion system and used for automatic control thereof.

Abstract: Systems and methods for determining operating discrepancy a process heater. The discrepancy may be identified by solving a fired-systems model of the heater. The fired-systems model is then compared to current operating data. If the sensed current operating data is outside of the expected value(s), as defined by the fired-systems model, the systems and methods may take a remediation action to resolve the discrepancy. The discrepancy may include convection fouling identification and identification of tramp-air leaks within the process heater that are otherwise not easily detected by a human operator.

Abstract: Systems and methods iteratively solve a fired-systems model of the process heater based on fuel information, a target heat release of the plurality of burners, ambient air information, and available airflow at each of the plurality of burners to identify optimized burner air register settings to achieve a target global excess oxygen level to be sensed by the oxygen sensor. The optimized burner air register settings may be output to a heater controller of the process heater for control of the process heater.

Abstract: This disclosure relates to pharmaceutical formulations for multi-specific binding proteins having an epidermal growth factor receptor 2 (ErbB2 or HER2)-binding scFv, an NKG2D-binding Fab, and an antibody Fc domain. Also provided are dosage regimens for such multi-specific binding proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.

Abstract: Described herein are multispecific binding proteins that bind NKG2D receptor, CD16, and CLEC12A, pharmaceutical compositions comprising the multispecific binding proteins, and therapeutic methods useful for the treatment of cancer.

Abstract: A framework module for use in modular building construction comprises a plurality of elongate upright and cross beams, rigidly connected at or towards their ends to form a box frame with open side and end faces, and; at least one connection point on each of the upright beams which is configured to allow mutual connection with an equivalent connection point located on a substantially identical adjacent framework module, so that a plurality of framework modules can be connected together to form an open-web truss of vertically and horizontally aligned members.