Patents by Inventor Ryan Murelli

Ryan Murelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL DISEASES
    Publication number: 20240115521
    Abstract: The present disclosure provides compounds, methods, and compositions which may be used to treat tuberculosis. In some embodiments, these compounds and compositions have a bactericidal property against Mycobacterium tuberculosis (Mtb). Methods of employing such agents are also provided.
    Type: Application
    Filed: September 19, 2023
    Publication date: April 11, 2024
    Inventors: Getahun ABATE, John TAVIS, David W. GRIGGS, Ryan MURELLI
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20240067756
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: June 7, 2023
    Publication date: February 29, 2024
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 11725064
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: August 15, 2023
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20220023428
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: May 17, 2021
    Publication date: January 27, 2022
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • INHIBITORS OF BUNYAVIRIDAE AND USES THEREOF
    Publication number: 20210393548
    Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 23, 2021
    Applicants: Saint Louis University, Research Foundation of The City University of New York, National and Kapodistrian University of Athens
    Inventors: John Edwin TAVIS, Grigoris ZOIDIS, Amelia PINTO, James BRIEN, Ryan MURELLI
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 11014992
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: May 25, 2021
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • Anti-fungal compounds
    Patent number: 10980754
    Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: April 20, 2021
    Assignees: SAINT LOUIS UNIVERSITY, RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Maureen J. Donlin, John Edwin Tavis, Ryan Murelli, Marvin J. Meyers
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20200354476
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: May 22, 2020
    Publication date: November 12, 2020
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 10703823
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: July 7, 2020
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20190127487
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: July 26, 2018
    Publication date: May 2, 2019
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • ANTI-FUNGAL COMPOUNDS
    Publication number: 20190099385
    Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
    Type: Application
    Filed: April 19, 2017
    Publication date: April 4, 2019
    Applicants: SAINT LOUIS UNIVERSITY, Research Foundation of the City University of New York
    Inventors: Maureen J. DONLIN, John Edwin TAVIS, Ryan MURELLI, Marvin J. MEYERS
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 10066026
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: September 4, 2018
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20160347863
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: March 28, 2016
    Publication date: December 1, 2016
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 9296708
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: March 29, 2016
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20150018395
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: September 8, 2014
    Publication date: January 15, 2015
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 8859509
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: October 14, 2014
    Assignee: Yale University
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • Chimeric small molecules for the recruitment of antibodies to cancer cells
    Patent number: 8852630
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: October 7, 2014
    Assignee: Yale University
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20120034295
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: June 30, 2011
    Publication date: February 9, 2012
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang
  • CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
    Publication number: 20110201563
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
    Type: Application
    Filed: May 13, 2009
    Publication date: August 18, 2011
    Applicant: YALE UNIVERSITY
    Inventors: David Spiegel, Ryan Murelli, Andrew Zhang