Patents by Inventor Ryan Neely
Ryan Neely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969596Abstract: Described herein are implantable closed-loop neuromodulation devices, systems that includes such devices and an interrogator configured to emit ultrasonic waves that power the device, methods of using such devices and systems, and methods of modulating neural activity. The implantable device can include one or more curved members extending from a body. The curved members are configured to at least partially circumscribe a nerve, and include one or more electrode pads. The body includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy; and a computational circuit configured to receive a detection signal based on a detected electrophysiological signal, generate a stimulation signal based on the detection signal, and operate the electrode pads of to emit an electrical pulse to the nerve based on the stimulation signal.Type: GrantFiled: August 28, 2019Date of Patent: April 30, 2024Assignee: IOTA BIOSCIENCES, INC.Inventors: Jose M. Carmena, Michel M. Maharbiz, Ryan Neely
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Publication number: 20240108882Abstract: A helical nerve cuff and an implantable device comprising the helical nerve cuff and a body comprising a wireless communication system are described herein. The implantable device can include a body having a wireless communication system; electrodes that can detect an electrophysiological signal transmitted by a nerve or emit an electrical pulse to the nerve; and a helical nerve cuff. Also described are methods of implanting the helical nerve cuff and the implantable device, as well as methods of making the helical nerve cuff and the implantable device.Type: ApplicationFiled: October 16, 2020Publication date: April 4, 2024Inventors: Michel M. MAHARBIZ, Jose M. CARMENA, Giana MONTERO GARNIER, Ryan NEELY, Joshua KAY, Carl Lance BOLING, Kathryn Mary PASWATERS
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Publication number: 20240100327Abstract: Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.Type: ApplicationFiled: October 16, 2020Publication date: March 28, 2024Inventors: Jose M. CARMENA, Michel M. MAHARBIZ, Ryan NEELY, Joshua KAY, Giana MONTERO GARNIER
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Patent number: 11890474Abstract: Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.Type: GrantFiled: April 19, 2019Date of Patent: February 6, 2024Assignee: IOTA BIOSCIENCES, INC.Inventors: Jose M. Carmena, Michel M. Maharbiz, Ryan Neely, Joshua Kay
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Publication number: 20240017071Abstract: Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.Type: ApplicationFiled: September 26, 2023Publication date: January 18, 2024Inventors: Jose M. CARMENA, Michel M. MAHARBIZ, Ryan NEELY, Joshua KAY
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Publication number: 20230414950Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.Type: ApplicationFiled: June 28, 2023Publication date: December 28, 2023Inventors: Michel M. MAHARBIZ, Ryan Neely, Joshua Kay, Jose M. Carmena
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Patent number: 11717689Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.Type: GrantFiled: May 19, 2021Date of Patent: August 8, 2023Assignee: Iota Biosciences, Inc.Inventors: Michel M. Maharbiz, Ryan Neely, Joshua Kay, Jose M. Carmena
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Publication number: 20230233851Abstract: Methods, implantable devices, and systems for treating a cancer or inhibiting cancer growth or recurrence in a subject are described herein. Such methods can include electrically stimulating a thoracic splanchnic nerve (such as a greater splanchnic nerve) of the subject with a plurality of electrical pulses emitted from one or more electrodes m electrical communication with the splanchnic nerve, wherein the plurality of electrical pulses triggers one or more action potentials in the splanchnic nerve to increase circulating natural killer (NK) cells in the subject. An implantable device may include one or more electrodes configured to be in electrical communication with a thoracic splanchnic nerve of a subject with cancer, and be configured to operate the one or more electrodes to electrically stimulate the splanchnic nerve with a plurality of electrical pulses that triggers one or more action potentials in the splanchnic nerve that increase circulating NK cells.Type: ApplicationFiled: June 4, 2021Publication date: July 27, 2023Inventors: Ryan NEELY, Michel M. MAHARBIZ, Jose M. CARMENA
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Publication number: 20220047869Abstract: Described herein are implantable device networks that include two or implantable devices configured to modulate neural activity in a subject. The network includes at least one implantable device that can detect a detection signal, such as an electrophysiological signal or a physiological condition. The network also includes a second implantable device configured to emit an electrical pulse based at least on information related to the detection signal. The implantable devices in the network can wirelessly communicate between each other, either directly or through an intermediate device.Type: ApplicationFiled: December 4, 2019Publication date: February 17, 2022Applicant: Iota Biosciences, Inc.Inventors: Jose M. CARMENA, Michel M. MAHARBIZ, Ryan NEELY
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Publication number: 20210308462Abstract: Described herein are implantable closed-loop neuromodulation devices, systems that includes such devices and an interrogator configured to emit ultrasonic waves that power the device, methods of using such devices and systems, and methods of modulating neural activity. The implantable device can include one or more curved members extending from a body. The curved members are configured to at least partially circumscribe a nerve, and include one or more electrode pads. The body includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy; and a computational circuit configured to receive a detection signal based on a detected electrophysiological signal, generate a stimulation signal based on the detection signal, and operate the electrode pads of to emit an electrical pulse to the nerve based on the stimulation signal.Type: ApplicationFiled: August 28, 2019Publication date: October 7, 2021Inventors: Jose M. CARMENA, Michel M. MAHARBIZ, Ryan NEELY
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Publication number: 20210268294Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Inventors: Michel M. MAHARBIZ, Ryan NEELY, Joshua KAY, Jose M. CARMENA
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Patent number: 11033746Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.Type: GrantFiled: April 19, 2019Date of Patent: June 15, 2021Assignee: IOTA BIOSCIENCES, INC.Inventors: Michel M. Maharbiz, Ryan Neely, Joshua Kay, Jose M. Carmena
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Patent number: 10898736Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: GrantFiled: May 1, 2019Date of Patent: January 26, 2021Assignee: The Regents of the University of CaliforniaInventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Publication number: 20200289857Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: ApplicationFiled: May 1, 2019Publication date: September 17, 2020Inventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Patent number: 10765865Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: GrantFiled: May 1, 2019Date of Patent: September 8, 2020Assignee: The Regents of the University of CaliforniaInventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Patent number: 10744347Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: GrantFiled: May 1, 2019Date of Patent: August 18, 2020Assignee: The Regents of the University of CaliforniaInventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Publication number: 20200230441Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: ApplicationFiled: May 1, 2019Publication date: July 23, 2020Inventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Patent number: 10682530Abstract: Described herein are implantable devices configured to detect an electrophysiological signal. Certain exemplary implantable devices comprise a first electrode and a second electrode configured to engage a tissue and detect an electrophysiological signal; an integrated circuit comprising a multi-transistor circuit and a modulation circuit configured to modulate a current based on the electrophysiological signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter encoding the electrophysiological signal from the tissue based on the modulated current. Also described herein are systems that include one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices.Type: GrantFiled: April 29, 2019Date of Patent: June 16, 2020Assignee: The Regents of the University of CaliforniaInventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Publication number: 20200114175Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: ApplicationFiled: May 1, 2019Publication date: April 16, 2020Inventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Publication number: 20200023209Abstract: Described herein are implantable devices configured to detect an electrophysiological signal. Certain exemplary implantable devices comprise a first electrode and a second electrode configured to engage a tissue and detect an electrophysiological signal; an integrated circuit comprising a multi-transistor circuit and a modulation circuit configured to modulate a current based on the electrophysiological signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter encoding the electrophysiological signal from the tissue based on the modulated current. Also described herein are systems that include one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices.Type: ApplicationFiled: April 29, 2019Publication date: January 23, 2020Inventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey