Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: An applicator and method for applying a microneedle device to skin. The applicator can include a housing and a reciprocating support structure slidably engaged with the housing. The reciprocating support structure can have a plurality of alignment feet. The applicator can have a lockout mechanism that prevents actuation if the alignment feet are not evenly aligned. The applicator can include a device life indicator that is capable of counting the number of use cycles that the applicator has undergone and providing feedback to the user. The applicator can include a dose timer capable of determining the time that has elapsed after actuation of the device and providing feedback to the user.

Abstract: A micro-needle device for delivering a dental local anesthetic that includes a micro-needle array and a hollow spheroid shaped container. The micro-needle array has a base and two or more elongate micro-needles. The elongate micro-needles have an interior surface defining an opening through the elongate micro-needle and the base has a first major surface and a second major surface through which the opening of the elongate micro-needle passes to provide a passage across the base. The hollow spheroid shaped container includes an inside surface, where the first major surface of the base and the inside surface of the hollow spheroid shaped container define a volume that is in fluid connection with each opening of the two or more of the elongate micro-needle. This allows the dental local anesthetic to flow from the volume of the micro-needle device through the opening of the two or more of the elongate micro-needle.

Abstract: An applicator and method for applying a microneedle device to a skin surface. The applicator can include a first portion comprising a microneedle array, and a second portion coupled to the first portion via a connector. The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. The method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.

Abstract: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Abstract: An applicator and method for applying a microneedle device to a skin surface. The applicator can include a first portion comprising a microneedle array, and a second portion coupled to the first portion via a connector. The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. The method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.

Abstract: An applicator (100) for applying a microneedle device to a skin surface comprising a first portion (102) comprising a microneedle array (107), and a second portion (104) coupled to the first portion via a connector (106). The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. A method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.

Abstract: An applicator (100) for applying a microneedle device to a skin surface. The applicator can include a microneedle device (106), a housing (102), and a connecting member (110). The connecting member can be configured to allow the microneedle device to move between: (i) a first position in which at least a portion of the microneedle device extends beyond the housing; and (ii) a second position in which the microneedle device is recessed within the housing when a threshold application force is applied to the microneedle device in a direction substantially perpendicular with respect to the microneedle device.

Abstract: The present disclosure provides for a micro-needle device (100, 200, 300, 400) that includes a micro-needle array (102, 202, 302, 402) and a liquid connection port (104, 204, 304, 404). The micro-needle array includes a base (106, 206, 306, 406), a sidewall (108, 208, 308, 408) and a top (110, 210, 310, 410), where the base includes two or more of an elongate micro-needle (112, 212, 312, 412) having an interior surface (114, 214, 314, 414) defining an opening 8116, 216, 316, 416) through the elongate micro-needle. The base has a first major surface (118, 218, 318, 418) and a second major surface (120, 220, 320, 420) through which the opening of the elongate micro-needle passes to provide a passage across the base. The top has an interior surface (122, 222, 322, 422) and the sidewall has an interior surface (126, 226, 326, 426), where the interior surface of the side wall, the interior surface of the top and the first major surface of the base define a volume (130, 230, 330, 430).

Abstract: A micro-needle device (100, 200, 300) for delivering a dental local anesthetic that includes a micro-needle array (102, 202, 302) and a hollow spheroid shaped container (108, 208, 308). The micro-needle array has a base (104, 204, 304)and two or more of an elongate micro-needle (106, 206, 306). The elongate micro-needle has an interior surface (110, 210, 310) defining an opening (112, 212, 312) through the elongate micro-needle and the base has a first major surface (114, 214, 314) and a second major surface (116, 216, 316) through which the opening of the elongate micro-needle passes to provide a passage across the base. The hollow spheroid shaped container includes an inside surface (120, 220, 320), where the first major surface of the base and the inside surface of the hollow spheroid shaped container define a volume that is in fluid connection with each opening of the two or more of the elongate micro-needle.

Abstract: An applicator and method for applying a microneedle device to skin. The applicator can include a housing and a reciprocating support structure slidably engaged with the housing. The reciprocating support structure can have a plurality of alignment feet. The applicator can have a lockout mechanism that prevents actuation if the alignment feet are not evenly aligned. The applicator can include a device life indicator that is capable of counting the number of use cycles that the applicator has undergone and providing feedback to the user. The applicator can include a dose timer capable of determining the time that has elapsed after actuation of the device and providing feedback to the user.

Abstract: An applicator (100) for applying a microneedle device to a skin surface. The applicator can include a microneedle device (106), a housing (102), and a connecting member (110). The connecting member can be configured to allow the microneedle device to move between: (i) a first position in which at least a portion of the microneedle device extends beyond the housing; and (ii) a second position in which the microneedle device is recessed within the housing when a threshold application force is applied to the microneedle device in a direction substantially perpendicular with respect to the microneedle device.

Abstract: An applicator (100) for applying a microneedle device to a skin surface comprising a first portion (102) comprising a microneedle array (107), and a second portion (104) coupled to the first portion via a connector (106). The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. A method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.

Abstract: Rapid, high-volume, intradermal infusion with minimal pain, is achived by applying an array of 10 to 30 hollow microneedles having a length of greater than 100 um to less than 1 mm into the skin of a patient, with a microneedle spacing of no less than 1.5 mm on average between adjacent microneedles, and pumping greater than 200 uL of fluid through the hollow microneedles at a rate of greater than 20 uL/min.