Patents by Inventor Ryan W. Simms

Ryan W. Simms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATMENT OF CANCERS
    Publication number: 20240165280
    Abstract: The present disclosure relates to methods of treating a subject having cancer with an 225Ac-radiopharmaceutical, which comprises 225Ac chelated with a compound of Formula I: wherein the compound binds to neurotensin receptor 1 (NTSR1) and does not cross the blood-brain barrier, and wherein the 225Ac-radiopharmaceutical is administered at a dosage of less than 10 MBq/kg of body weight of the subject or is administered as a unitary dosage of less than 40 MBq to the subject.
    Type: Application
    Filed: April 22, 2022
    Publication date: May 23, 2024
    Inventors: Eric S. Burak, John R. Forbes, Ryan W. Simms
  • Residualizing linkers and uses thereof
    Patent number: 11793895
    Abstract: The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: October 24, 2023
    Inventors: John Fitzmaurice Valliant, Eric Steven Burak, Neil G. Cockburn, Alla Darwish, Joel A. Drewry, John R. Forbes, Meiduo Hu, Ryan W. Simms, Karin A. Stephenson, Tao Wu
  • MACROCYCLIC CHELATES AND USES THEREOF
    Publication number: 20210395281
    Abstract: The present disclosure relates to macrocyclic chelates including a macrocyclic chelating moiety of a metal complex thereof, a bifunctional linker, and a therapeutic or targeting moiety. Also disclosed are methods for preparation of the same, and use thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: December 23, 2021
    Inventors: Stuart J. Mahoney, Michael B. Johansen, Matthew D. Moran, Melissa Chassé, Ryan W. Simms, Eric S. Burak, John F. Valliant