Patents by Inventor Ryoichi Horisaki
Ryoichi Horisaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240133792Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry.Type: ApplicationFiled: August 25, 2023Publication date: April 25, 2024Inventors: Sadao Ota, Ryoichi Horisaki, Yoko Kawamura, Masashi Ugawa, Issei Sato
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Patent number: 11906722Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.Type: GrantFiled: November 17, 2022Date of Patent: February 20, 2024Assignees: OSAKA UNIVERSITY, The University of TokyoInventors: Ryoichi Horisaki, Jun Tanida, Sadao Ota
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Patent number: 11867610Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.Type: GrantFiled: January 10, 2023Date of Patent: January 9, 2024Assignees: The University of Tokyo, Osaka UniversityInventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
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Patent number: 11861889Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.Type: GrantFiled: November 29, 2022Date of Patent: January 2, 2024Assignees: The University of Tokyo, Osaka UniversityInventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
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Patent number: 11788948Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry.Type: GrantFiled: December 8, 2020Date of Patent: October 17, 2023Assignees: ThinkCyte, Inc., University of Tokyo, Osaka UniversityInventors: Sadao Ota, Ryoichi Horisaki, Yoko Kawamura, Masashi Ugawa, Issei Sato
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Publication number: 20230288318Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.Type: ApplicationFiled: January 10, 2023Publication date: September 14, 2023Inventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
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Publication number: 20230237789Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.Type: ApplicationFiled: November 29, 2022Publication date: July 27, 2023Inventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
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Publication number: 20230213747Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.Type: ApplicationFiled: November 17, 2022Publication date: July 6, 2023Inventors: Ryoichi Horisaki, Jun Tanida, Sadao Ota
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Patent number: 11579075Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.Type: GrantFiled: June 2, 2021Date of Patent: February 14, 2023Assignees: The University of Tokyo, Osaka UniversityInventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
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Publication number: 20230010572Abstract: Irradiation light in a visible light region is irradiated to a sample while switching irradiation of infrared light IR having a wavelength that corresponds to the infrared absorption spectrum of an observation target material included in the sample between a first state and a second state. A first image and a second image are generated based on the phase distribution, the intensity distribution, and the polarization direction distribution of the light including the irradiation light that has passed through the sample in synchronization with the switching of the infrared light IR irradiation between the first state and the second state. Subsequently, an output image is generated so as to represent one from among the position, size, and shape based on the difference and/or ratio with respect to the pixel values for each pixel between the first image and the second image.Type: ApplicationFiled: July 12, 2019Publication date: January 12, 2023Inventors: Takuro IDEGUCHI, Keiichiro TODA, Miu TAMAMITSU, Kazuki HASHIMOTO, Ryoichi HORISAKI
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Patent number: 11549880Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.Type: GrantFiled: August 15, 2019Date of Patent: January 10, 2023Assignees: OSAKA UNIVERSITY, The University of TokyoInventors: Ryoichi Horisaki, Jun Tanida, Sadao Ota
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Patent number: 11542461Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.Type: GrantFiled: June 17, 2021Date of Patent: January 3, 2023Assignees: The University of Tokyo, OSAKA UNIVERSITYInventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
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Patent number: 11412118Abstract: An electromagnetic wave phase/amplitude generation device includes a radiation unit configured to radiate electromagnetic waves of a random radiation pattern on a spatial frequency in which a state of the electromagnetic waves to be radiated for each divided region is determined to an imaging object, an imaging unit configured to generate a captured image by imaging scattered electromagnetic waves that are electromagnetic waves generated when the imaging object scatters the electromagnetic waves of the radiation pattern radiated by the radiation unit, and a generation unit configured to generate information indicating at least a phase and amplitude of the electromagnetic waves from the imaging object by performing an arithmetic sparsity constraint operation according to sparsity of the imaging object on the basis of the captured image generated by the imaging unit, information indicating the radiation pattern, and information indicating a signal of the imaging object.Type: GrantFiled: November 4, 2020Date of Patent: August 9, 2022Assignee: Osaka UniversityInventors: Ryoichi Horisaki, Jun Tanida, Riki Egami
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Publication number: 20220041963Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.Type: ApplicationFiled: June 17, 2021Publication date: February 10, 2022Inventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
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Publication number: 20210404945Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal infoimation of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.Type: ApplicationFiled: June 2, 2021Publication date: December 30, 2021Inventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
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Patent number: 11098275Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.Type: GrantFiled: October 28, 2016Date of Patent: August 24, 2021Assignees: THE UNIVERSITY OF TOKYO, OSAKA UNIVERSITYInventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
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Patent number: 11054363Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.Type: GrantFiled: July 22, 2020Date of Patent: July 6, 2021Assignees: The University of Tokyo, Osaka UniversityInventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
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Publication number: 20210190669Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry.Type: ApplicationFiled: December 8, 2020Publication date: June 24, 2021Inventors: Sadao Ota, Ryoichi Horisaki, Yoko Kawamura, Masashi Ugawa, Issei Sato
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Publication number: 20210120156Abstract: An electromagnetic wave phase/amplitude generation device includes a radiation unit configured to radiate electromagnetic waves of a random radiation pattern on a spatial frequency in which a state of the electromagnetic waves to be radiated for each divided region is determined to an imaging object, an imaging unit configured to generate a captured image by imaging scattered electromagnetic waves that are electromagnetic waves generated when the imaging object scatters the electromagnetic waves of the radiation pattern radiated by the radiation unit, and a generation unit configured to generate information indicating at least a phase and amplitude of the electromagnetic waves from the imaging object by performing an arithmetic sparsity constraint operation according to sparsity of the imaging object on the basis of the captured image generated by the imaging unit, information indicating the radiation pattern, and information indicating a signal of the imaging object.Type: ApplicationFiled: November 4, 2020Publication date: April 22, 2021Inventors: Ryoichi Horisaki, Jun Tanida, Riki Egami
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Patent number: 10904415Abstract: An electromagnetic wave phase/amplitude generation device includes a radiation unit configured to radiate electromagnetic waves of a random radiation pattern on a spatial frequency in which a state of the electromagnetic waves to be radiated for each divided region is determined to an imaging object, an imaging unit configured to generate a captured image by imaging scattered electromagnetic waves that are electromagnetic waves generated when the imaging object scatters the electromagnetic waves of the radiation pattern radiated by the radiation unit, and a generation unit configured to generate information indicating at least a phase and amplitude of the electromagnetic waves from the imaging object by performing an arithmetic sparsity constraint operation according to sparsity of the imaging object on the basis of the captured image generated by the imaging unit, information indicating the radiation pattern, and information indicating a signal of the imaging object.Type: GrantFiled: February 11, 2019Date of Patent: January 26, 2021Assignee: Osaka UniversityInventors: Ryoichi Horisaki, Jun Tanida, Riki Egami