Abstract: A novel method for controlled release of compounds having antimicrobial activity and a novel coating composition capable of controlled release of compounds having antimicrobial activity is provided.This invention relates to a method for releasing a compound having antimicrobial activity from a matrix at a controlled rate, which comprises incorporating an enzyme and a substrate in said matrix beforehand to allow said enzyme and said substrate to react with each other in said matrix to thereby produce said compound having antimicrobial activity; and further relates to a coating composition comprising a film-forming resin, an enzyme, and a substrate, said enzyme being capable of reacting with said substrate to produce a compound having antimicrobial activity.

Abstract: A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to prevent the settlement by means of thick slime layer, i.e. bio-jelly, deposited on said surface. The present invention also provides a bio-jelly producing agent and a bio-jelly producing paint both useful for the present method. Further, the present invention provides a novel low toxic antifouling agent.

Abstract: This invention is related to glucoxide derivatives for enzyme modification of the following general formula (1), to provide a lipid-coated enzyme showing high activity in organic solvents; antifouling paint compositions containing a lipid-coated enzyme being stable in organic solvents by coating with a C.sub.6 to C.sub.30 lipid, and a paint resin, to be capable of forming paint films having good antifouling activity and durability and allowing an enzyme to retain good stability in the paint and in paint films; and self-polishing antifouling paint compositions containing an enzyme-susceptible resin and a lipid-coated enzyme capable of catalyzing the degradation of said resin and being stable in organic solvents by coating with a C.sub.6 to C.sub.30 lipid, to retain the antifouling effect for a prolonged period of time without adversely affecting the environment.