Patents by Inventor Ryu Nakao

Ryu Nakao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing 2-bromo-4,5-dialkoxy benzoic acid
    Patent number: 9096511
    Abstract: Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: August 4, 2015
    Assignee: ZERIA PHARMACEUTICAL CO., LTD.
    Inventor: Ryu Nakao
  • Method for producing aminothiazole derivative and production intermediate
    Patent number: 9000163
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: April 7, 2015
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • Method for producing aminothiazole derivative and production intermediate
    Patent number: 8841461
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: September 23, 2014
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • Method for producing aminothiazole derivative and production intermediate
    Patent number: 8772528
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: July 8, 2014
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE
    Publication number: 20140058104
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: ZERIA PHARMACEUTICAL CO., LTD.
    Inventors: Masaaki NAGASAWA, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE
    Publication number: 20140058112
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: ZERIA PHARMACEUTICAL CO., LTD.
    Inventors: Masaaki NAGASAWA, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE
    Publication number: 20140046088
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 13, 2014
    Applicant: ZERIA PHARMACEUTICAL CO., LTD.
    Inventors: Masaaki NAGASAWA, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • Method for producing aminothiazole derivative and production intermediate
    Patent number: 8586761
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: November 19, 2013
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID
    Publication number: 20130253222
    Abstract: Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.
    Type: Application
    Filed: December 6, 2011
    Publication date: September 26, 2013
    Applicant: Zeria Pharmaceutical Co., LTD
    Inventor: Ryu Nakao
  • Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof
    Patent number: 8329913
    Abstract: An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: December 11, 2012
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masakazu Murata, Yoshihiko Itokazu, Ryu Nakao
  • Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof
    Publication number: 20100286210
    Abstract: An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.
    Type: Application
    Filed: October 28, 2005
    Publication date: November 11, 2010
    Applicant: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masakazu Murata, Yoshihiko Itokazu, Ryu Nakao
  • Method For Producing Aminothiazole Derivative And Production Intermediate
    Publication number: 20080021221
    Abstract: Provided is a method for selectively demethylating a 2-methoxy group.
    Type: Application
    Filed: August 23, 2005
    Publication date: January 24, 2008
    Applicant: ZERIA PHARMACEUTICAL CO., LTD. , a corporation
    Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
  • Solid-phase-supported transition metal catalysts
    Publication number: 20040102631
    Abstract: Solid-supported transition metal complex catalysts each of which is represented by the following formula (I): 1
    Type: Application
    Filed: September 8, 2003
    Publication date: May 27, 2004
    Inventors: Yasuhiro Uozumi, Ryu Nakao
  • Process for producing 2-hydroxybenzamide derivatives
    Patent number: 6197970
    Abstract: The present invention is directed to a process for producing 2-hydroxybenzamide derivatives (2) or (5) according to either one of the following reaction schemes.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: March 6, 2001
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masaaki Nagasawa, Hiroyasu Nishioka, Takanori Suzuki, Eiichi Nagano, Katsuyuki Ishii, Ryu Nakao