Abstract: An information processing apparatus (2000) detects an abnormal region (30) from a moving image frame (14). The abnormal region (30) is a region that is estimated to represent an abnormal part inside a body of a subject. The information processing apparatus (2000) generates and outputs output information based on the number of detected abnormal regions (30).

Abstract: A processor receives an input of finding information indicating at least one finding, which is desired to be searched for, on a query base image, which includes a part desired to be searched for and is a source of a query image, to derive the query image to which the finding has been added, derives at least one added finding feature amount indicating an image feature for the added finding, and derives a query normal feature amount indicating an image feature for a normal region included in the part in the query base image. The processor derives similarities between the query image and a plurality of reference images including findings on the basis of comparisons between the added finding feature amount and the query normal feature amount and the like with reference to an image database in which the plurality of reference images have been registered and extracts the reference image that is similar to the query image as a similar image from the image database on the basis of the similarities.

Abstract: Provided are an information processing device, a display method, and a program that allow to easily grasp during examination that a lesion is captured how long before from now which is detected by detection processing for an image captured by an endoscope. An information processing device (1) includes: an image acquisition unit (2) configured to sequentially acquire a current image captured by an endoscope; a lesion detection unit (3) configured to sequentially perform detection processing of a lesion site on the images sequentially acquired by the image acquisition unit (2); and a display control unit (4) configured to display, on a display device, a degree of lapse of time up to a current time from a capturing time of the image in which the lesion site is detected by the lesion detection unit (3).

Abstract: A processor encodes a target image to derive at least one first feature amount indicating an image feature for an abnormality of a region of interest included in the target image. In addition, the processor encodes the target image to derive at least one second feature amount indicating an image feature for an image in a case in which the region of interest included in the target image is a normal region.

Abstract: A non-transitory computer-readable recording medium has stored therein an evaluating program for causing a computer to execute a process including: specifying a wall of an inspection target in two or more moving images being obtained by photographing two types of cross sections of the inspection target, the two types of cross sections being orthogonal to each other; evaluating photographing quality of each of a plurality of first divisional regions obtained by dividing a region corresponding to the wall specified in a first image related to a first cross section among the two or more moving images; and evaluating photographing quality of each of a plurality of second divisional regions obtained by dividing a region corresponding to the wall specified in a second image related to a second cross section among the two or more moving images, the second cross section being different from the first cross section.

Abstract: An information processing apparatus (2000) detects an abnormal region (30) in each of a plurality of video frames (14) constituting video data (12) in which the inside of a body is captured. The information processing apparatus (2000) outputs output information related to the detected abnormal region (30). Herein, the information processing apparatus (2000) starts outputting of the output information when a detection score based on a proportion of the number of the video frames (14) in which the abnormal region (30) is detected becomes equal to or more than a first threshold value in a state where outputting of the output information is not being performed. Further, the information processing apparatus (2000) ends outputting of the output information when the detection score becomes equal to or less than a second threshold value in a state where outputting of the output information is being performed.

Abstract: A non-transitory computer-readable recording medium stores therein an examination assisting program that causes a computer to execute a process including: performing a site detecting process that uses an object detection technique on each of a plurality of ultrasound examination images taken of an examined subject by performing a scan on the examined subject; and displaying a site detection map in which a detection result of each of a plurality of sites included in the examined subject is kept in correspondence with the scan, on a basis of detection results from the site detecting process.

Abstract: An information processing apparatus (2000) detects an abnormal region (30) from a moving image frame (14). The abnormal region (30) is a region that is estimated to represent an abnormal part inside a body of a subject. The information processing apparatus (2000) generates and outputs output information based on the number of detected abnormal regions (30).

Abstract: An annotation support apparatus manages a medical image on the basis of an attribute of each medical image, using a hierarchical structure that has one medical image as a node and includes a medical image hierarchy to which a node of the medical image belongs and at least one of an upper hierarchy higher than the medical image hierarchy or a lower hierarchy lower than the medical image hierarchy. The annotation support apparatus includes: an image acquisition unit that acquires the medical image; a display unit; an annotation input receiving unit that receives designation of any one of the node of the medical image or a node associated with the node of the medical image in the hierarchical structure and an input of annotation information related to the designated node; and an annotation storage unit that stores the annotation information to be associated with the designated node.

Abstract: A non-transitory computer-readable recording medium storing therein an anomalousness determination program that causes a computer to execute a process includes: sensing a region in an object in each of a plurality of ultrasound examination images using an object sensing technique; based on a result of the sensing and a structure of the object, acquiring a result of sensing each of a plurality of regions in the object in each of the ultrasound examination images; and determining anomalousness in the object based on the result of sensing each of the regions in the ultrasound examination images.

Abstract: A non-transitory computer-readable recording medium storing therein an anomalousness determination program that causes a computer to execute a process includes: sensing a region in an object in each of a plurality of ultrasound examination images using an object sensing technique; based on a result of the sensing and a structure of the object, acquiring a result of sensing each of a plurality of regions in the object in each of the ultrasound examination images; and determining anomalousness in the object based on the result of sensing each of the regions in the ultrasound examination images.

Abstract: A non-transitory computer-readable recording medium stores therein an examination assisting program that causes a computer to execute a process including: performing a site detecting process that uses an object detection technique on each of a plurality of ultrasound examination images taken of an examined subject by performing a scan on the examined subject; and displaying a site detection map in which a detection result of each of a plurality of sites included in the examined subject is kept in correspondence with the scan, on a basis of detection results from the site detecting process.

Abstract: The present invention arises from the discovery that the SMYD2 gene is both specifically over-expressed in cancer and involved in cancer cell survival. The present invention features methods for detecting or diagnosing the presence of or predisposition for developing cancer, using the SMYD2 gene as a diagnostic marker. The present invention further provides methods of screening for therapeutic substances useful in either or both of the treatment and prevention of cancer.

Abstract: The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.

Abstract: Objective methods for detecting or diagnosing cancer, or determining a predisposition for developing cancer, particularly lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor, are described herein. In one embodiment, the diagnostic method involves determining an expression level of the SUV39H2 gene. The present invention further provides methods of screening for candidate substances useful in the treatment and/or prevention of an SUV39H2-associated cancer, such as lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor. The present invention further provides methods of inhibiting the cell growth and thereby treating or alleviating symptoms of an SUV39H2 associated cancer.

Abstract: Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.

Abstract: The present invention relates to the roles played by the SUV420H1 and SUV420H2 genes in carcinogenesis and features a method for treating or preventing cancer by administering a double-stranded molecule against the SUV420H1 or SUV420H2 gene or a composition or vector containing such a double-stranded molecule. The present invention also features methods and kits for detecting or diagnosing cancer in a subject, including detecting an expression level of the SUV420H1 or SUV420H2 gene. The present invention further features methods and kits for assessing or determining the prognosis of a subject with cancer, including detecting the expression level of an SUV420H2 gene. Also, disclosed are methods of screening for candidate substances for treating or preventing cancer or inhibiting cancer cell growth, using as an index their effect on the expression or activity of SUV420H1 or SUV420H2.

Abstract: Objective methods for diagnosing a predisposition to developing cancer, for example, bladder cancer, breast cancer, cholangiocellular carcinoma, CML, esophageal cancer, HCC, NSCLC, SCLC, osteosarcoma, pancreatic cancer, prostate cancer, renal cell carcinoma, soft tissue tumor and lymphoma, are described herein. In one embodiment, the diagnostic method involves determining an expression level of a WHSC1 or WHSC1L1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of WHSC1 or WHSC1L1 associated disease, such as a cancer, e.g., bladder cancer, breast cancer, cholangiocellular carcinoma, CML, esophageal cancer, HCC, NSCLC, SCLC, osteosarcoma, pancreatic cancer, prostate cancer, renal cell carcinoma, soft tissue tumor and lymphoma. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of WHSC1 or WHSC1L1 associated diseases.

Abstract: The present invention relates to methods for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of VEGFR1 by SMYD3. The invention further provides methods and pharmaceutical compositions for treating and preventing colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.

Abstract: The invention concerns materials and methods relating to the use of OMD (osteomodulin) and\or PRELP (Proline/arginine-rich end leucine-rich repeat protein) expression, particularly under-expression, to discriminate cancer and non-cancer cells in a variety of cancers. The invention further provides methods and materials based on OMD and\or PRELP for use in therapy e.g. to suppress cancer initiation or development.