Patents by Inventor Ryutaro Wakayama

Ryutaro Wakayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-acylaminothiazole derivative or salt thereof
    Patent number: 8765764
    Abstract: A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: July 1, 2014
    Assignee: Astellas Pharma, Inc.
    Inventors: Keizo Sugasawa, Susumu Watanuki, Yuji Koga, Hiroshi Nagata, Ryutaro Wakayama, Fukushi Hirayama, Ken-Ichi Suzuki
  • 2-acylaminothiazole derivative or salt thereof
    Patent number: 8338429
    Abstract: A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: December 25, 2012
    Assignee: Astellas Pharma, Inc.
    Inventors: Keizo Sugasawa, Susumu Watanuki, Yuji Koga, Hiroshi Nagata, Ryutaro Wakayama, Fukushi Hirayama, Ken-ichi Suzuki
  • Sulfonamide compound or salt thereof
    Patent number: 7973078
    Abstract: A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular a lower urinary tract symptom. It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: July 5, 2011
    Assignee: Astellas Pharma Inc.
    Inventors: Hideki Kubota, Susumu Toda, Issei Tsukamoto, Yuta Fukuda, Ryutaro Wakayama, Kazuki Ono, Toru Watanabe, Hidenori Azami
  • 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
    Publication number: 20100222361
    Abstract: A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
    Type: Application
    Filed: November 10, 2009
    Publication date: September 2, 2010
    Applicant: Astellas Pharma Inc.
    Inventors: Keizo SUGASAWA, Susumu WATANUKI, Yuji KOGA, Hiroshi NAGATA, Ryutaro WAKAYAMA, Fukushi HIRAYAMA, Ken-ichi SUZUKI
  • 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
    Publication number: 20100222329
    Abstract: A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
    Type: Application
    Filed: November 10, 2009
    Publication date: September 2, 2010
    Applicant: Astellas Pharma Inc.
    Inventors: Keizo Sugasawa, Susumu Watanuki, Yuji Koga, Hiroshi Nagata, Ryutaro Wakayama, Fukushi Hirayama, Ken-ichi Suzuki
  • 2-Acylaminothiazole derivative or salt thereof
    Patent number: 7638536
    Abstract: A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: December 29, 2009
    Assignee: Astellas Pharma Inc.
    Inventors: Keizo Sugasawa, Susumu Watanuki, Yuji Koga, Hiroshi Nagata, Kazuyoshi Obitsu, Ryutaro Wakayama, Fukushi Hirayama, Ken-ichi Suzuki
  • SULFONAMIDE COMPOUND OR SALT THEREOF
    Publication number: 20090312328
    Abstract: [Object] A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom. [Means for Solution] It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.
    Type: Application
    Filed: August 9, 2007
    Publication date: December 17, 2009
    Applicant: Astellas Pharma Inc.
    Inventors: Hideki Kubota, Susumu Toda, Issei Tsukamoto, Yuta Fukuda, Ryutaro Wakayama, Kazuki Ono, Toru Watanabe, Hidenori Azami
  • Propane-1, 3-dione derivative
    Patent number: 7569688
    Abstract: Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: August 4, 2009
    Assignee: Astellas Pharma Inc.
    Inventors: Masaaki Hirano, Eiji Kawaminami, Akira Toyoshima, Hiroyuki Moritomo, Norio Seki, Ryutaro Wakayama, Minoru Okada, Toshiyuki Kusayama
  • 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or salt thereof
    Publication number: 20060142268
    Abstract: To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 15, 2006
    Publication date: June 29, 2006
    Inventors: Hiroyuki Koshio, Akio Kakefuda, Ippei Sato, Ryutaro Wakayama, Masanao Sanagi
  • 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
    Patent number: 7056910
    Abstract: To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: June 6, 2006
    Assignee: Astellas Pharma Inc.
    Inventors: Hiroyuki Koshio, Akio Kakefuda, Ippei Sato, Ryutaro Wakayama, Masanao Sanagi
  • Propane-1, 3-dione derivative
    Publication number: 20050267110
    Abstract: Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
    Type: Application
    Filed: June 20, 2005
    Publication date: December 1, 2005
    Inventors: Masaaki Hirano, Eiji Kawaminami, Akira Toyoshima, Hiroyuki Moritomo, Norio Seki, Ryutaro Wakayama, Minoru Okada, Toshiyuki Kusayama
  • Propane-1,3-dione derivative
    Patent number: 6960591
    Abstract: Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
    Type: Grant
    Filed: July 4, 2001
    Date of Patent: November 1, 2005
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Masaaki Hirano, Eiji Kawaminami, Akira Toyoshima, Hiroyuki Moritomo, Norio Seki, Ryutaro Wakayama, Minoru Okada, Toshiyuki Kusayama
  • 2-Acylaminothiazole derivative or salt thereof
    Publication number: 20050153977
    Abstract: A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
    Type: Application
    Filed: January 15, 2003
    Publication date: July 14, 2005
    Inventors: Keizo Sugasawa, Susumu Watanuki, Yuji Koga, Hiroshi Nagata, Kazuyoshi Obitsu, Ryutaro Wakayama, Fukushi Hirayama, Ken-ichi Suzuki
  • 1,4,5,6-Tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
    Publication number: 20040034012
    Abstract: To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 27, 2003
    Publication date: February 19, 2004
    Inventors: Hiroyuki Koshio, Akio Kakefuda, Ippei Sato, Ryutaro Wakayama, Masanao Sanagi
  • Propane-1,3-dione derivatives
    Publication number: 20030191164
    Abstract: Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
    Type: Application
    Filed: December 19, 2002
    Publication date: October 9, 2003
    Inventors: Masaaki Hirano, Eiji Kawaminami, Akira Toyoshima, Hiroyuki Moritomo, Norio Seki, Ryutaro Wakayama, Minoru Okada, Toshiyuki Kusayama