Abstract: The invention provides a Platform or Application, via numerous systems and methods, involving software, code, pseudo-code, databases, schemas, algorithms, inference engines, and user interfaces including but not limited to Complex Event Processing (CEP) artificial intelligence, for pharmacotherapy management and evaluation (specifically managing medication therapy regimens), maximizing patient safety and Medication efficacy, coordinating care among disparate Providers, improving clinical outcomes, regulatory reporting, and research, learning, or knowledge discovery via analysis. More specifically, the invention is comprised of a mobile and digital health intervention platform with various modules addressing health challenges related to medication non-adherence behaviors, predicting and preventing medication non-adherence, identifying and overcoming reasons for non-adherence, identifying risks or preventing adverse drug interactions (ADR) (e.g.