Patents by Inventor Sabine M. Axt

Sabine M. Axt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Local anesthetic compounds and uses
    Patent number: 6576791
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: June 10, 2003
    Assignee: Theravance, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, Witold N. Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
  • Local anesthetic compounds and uses
    Patent number: 6495681
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: December 17, 2002
    Assignee: Theravance Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, Witold Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
  • Local anesthetic compounds and uses
    Patent number: 6462034
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: October 8, 2002
    Assignee: Theravance, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice, Huiwei Wu, Witold Hruzewicz
  • Local anesthetic compounds
    Patent number: 6436919
    Abstract: This invention is directed to novel local anesthetic compounds, pharmaceutical compositions containing these compounds, methods of use and methods of preparing these compounds.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 20, 2002
    Assignee: Theravance Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu
  • Local anesthetic compounds
    Patent number: 6355637
    Abstract: This invention provides novel quinazolinone compounds and pharmaceutically acceptable salts thereof, which are useful as local anesthetics. This invention also provides pharmaceutical compositions containing such compounds; methods for producing local anesthesia in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: March 12, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu
  • Local anesthetic compounds and uses
    Patent number: 6337423
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: January 8, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, Witold Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice