Patents by Inventor Sabine M. Brouxhon

Sabine M. Brouxhon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS TARGETING THE SOLUBLE EXTRACELLULAR DOMAIN OF E-CADHERIN AND RELATED METHODS FOR CANCER THERAPY
    Publication number: 20190352380
    Abstract: The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof; expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains.
    Type: Application
    Filed: January 24, 2019
    Publication date: November 21, 2019
    Inventors: Sabine M. Brouxhon, M. Kerry O'Banion, Stephanos Kyrkandies
  • COMPOSITIONS TARGETING THE SOLUBLE EXTRACELLULAR DOMAIN OF E-CADHERIN AND RELATED METHODS FOR CANCER THERAPY
    Publication number: 20160046701
    Abstract: The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof; expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains.
    Type: Application
    Filed: March 30, 2015
    Publication date: February 18, 2016
    Inventors: Sabine M. Brouxhon, M. Kerry O'Banion, Stephanos Kyrkanides
  • COMPOSITIONS AND METHODS RELATING TO DETECTION OF SOLUBLE E-CADHERIN IN NEURODEGENERATIVE DISEASE
    Publication number: 20110165698
    Abstract: Disclosed herein are compositions and methods for diagnosing, detecting, or monitoring neural disease, conditions, or disorders involving detection of soluble E-cadherin.
    Type: Application
    Filed: May 26, 2009
    Publication date: July 7, 2011
    Inventors: Sabine M. Brouxhon, Stephanos Kyrkanidies, Ross H. Tallents, M. Kerry O'Banion