Patents by Inventor Sacha Gnjatic

Sacha Gnjatic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREVENTING, DETECTING, AND TREATING INFLAMMATORY BOWEL DISEASE
    Publication number: 20230405086
    Abstract: The present disclosure relates to a composition comprising a post-translationally modified Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) protein. The disclosure further relates to methods of preventing or treating Crohn's Disease and/or a condition resulting from Crohn's Disease in a subject. The disclosure further relates to methods for diagnosing and/or predicting severity of and/or treating Crohn's Disease in a subject. Also disclosed are methods for diagnosing inflammatory bowel disease in a subject and methods for diagnosing a pre-disease state of Crohn's Disease in a subject.
    Type: Application
    Filed: April 30, 2021
    Publication date: December 21, 2023
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Sacha GNJATIC, Arthur MORTHA, Jean-Frederic COLOMBEL, Romain REMARK, Miriam MERAD
  • TISSUE PROFILING USING MULTIPLEXED IMMUNOHISTOCHEMICAL CONSECUTIVE STAINING
    Publication number: 20190120845
    Abstract: The present invention relates to methods and compositions for sequential multidimensional immunohistochemical analyses of tissues.
    Type: Application
    Filed: April 17, 2017
    Publication date: April 25, 2019
    Inventors: Romain Remark, Miriam Merad, Sacha Gnjatic
  • IMMUNOGENIC COMPOSITIONS USEFUL IN PROVOKING AN INTEGRATED RESPONSE TO TUMOR ANTIGENS
    Publication number: 20140255436
    Abstract: The invention relates to an immunogenic composition and its use. It comprises “OLPs,” or overlapping peptides, derived from a longer, tumor antigen, in combination with polyICLC, and Montanide.
    Type: Application
    Filed: April 7, 2014
    Publication date: September 11, 2014
    Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH
    Inventors: Takemasa TSUJI, Sacha Gnjatic, Gerd Ritter, Lloyd J. Old
  • Methods for stimulating an immune response using bacterial antigen delivery system
    Patent number: 8357373
    Abstract: The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: January 22, 2013
    Assignees: Ludwig Institute for Cancer Research, Yale University
    Inventors: Lloyd J. Old, Gerd Ritter, Hiroyoshi Nishikawa, Sacha Gnjatic, Jorge E. Galan
  • IMMUNOGENIC COMPOSITIONS USEFUL IN PROVOKING AN INTEGRATED RESPONSE TO TUMOR ANTIGENS
    Publication number: 20120328660
    Abstract: The invention relates to an immunogenic composition and its use. It comprises “OLPs,” or overlapping peptides, derived from a longer, tumor antigen, in combination with polyICLC, and Montanide.
    Type: Application
    Filed: May 31, 2012
    Publication date: December 27, 2012
    Inventors: Takemasa TSUJI, Sacha Gnjatic, Gerd Ritter, Lloyd J. Old
  • SEROMIC ANALYSIS OF OVARIAN CANCER
    Publication number: 20120283115
    Abstract: The invention relates to the discovery of cancer antigens associated with ovarian cancer. In further aspects, the invention relates to methods, compositions and kits for the diagnosis and treatment of cancer, particularly ovarian and pancreatic cancers.
    Type: Application
    Filed: August 30, 2010
    Publication date: November 8, 2012
    Applicant: Ludwig Institute for Cancer Research Ltd.
    Inventors: Gerd Ritter, Lloyd J. Old, Constance Old, Sacha Gnjatic, Kunle Odunsi, Dirk Jager
  • Method for inducing immune response to NY-CO-58
    Patent number: 7803382
    Abstract: The invention provides methods, compositions and kits for inducing and/or enhancing an immune response in a subject. The invention in some aspects includes polypeptide and nucleic acid molecules that induce and/or enhance an immune response. In some aspects of the invention, the polypeptide and/or nucleic acid molecules of the invention are useful to induce and/or enhance an immune response in a subject who has or is suspected of having cancer.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: September 28, 2010
    Assignees: Ludwig Institute for Cancer Research Ltd., Chancelors Masters and Scholars of the University of Oxford
    Inventors: Lloyd J. Old, Sacha Gnjatic, Djordje Atanackovic, Vincenzo Cerundolo, Khoon-Lin Ling
  • Methods for Stimulating an Immune Response Using Bacterial Antigen Delivery System
    Publication number: 20090324651
    Abstract: The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.
    Type: Application
    Filed: October 3, 2006
    Publication date: December 31, 2009
    Inventors: Lloyd J. Old, Gerd Ritter, Hiroyoshi Nishikawa, Sacha Gnjatic, Jorge E. Galan
  • INDUCTION OF REGULATORY T CELL-RESISTANT HELPER CD4+ T CELLS
    Publication number: 20090136446
    Abstract: The invention relates to stimulation of immune responses against antigen(s) and overcoming regulatory T cell suppression of such immune responses against antigen(s).
    Type: Application
    Filed: October 31, 2008
    Publication date: May 28, 2009
    Applicant: Ludwig Institute for Cancer Research Ltd.
    Inventors: HIROYOSHI NISHIKAWA, HIROSHI SHIKU, GERD RITTER, LLOYD J. OLD, SACHA GNJATIC
  • Colon cancer antigen panel
    Publication number: 20080226664
    Abstract: The invention provides methods, compositions and kits for inducing and/or enhancing an immune response in a subject. The invention in some aspects includes polypeptide and nucleic acid molecules that induce and/or enhance an immune response. In some aspects of the invention, the polypeptide and/or nucleic acid molecules of the invention are useful to induce and/or enhance an immune response in a subject who has or is suspected of having cancer.
    Type: Application
    Filed: September 9, 2004
    Publication date: September 18, 2008
    Applicants: Ludwig Institute for Cancer Research, Chancellors Masters and Scholars of the University of Oxford
    Inventors: Lloyd J. Old, Sacha Gnjatic, Djordje Atanackovic, Vincenzo Cerundolo, Khoon-Lin Ling
  • Isolated Ny-Eso-1 Peptides Which Bind To Hla Class II Molecules And Uses Thereof
    Publication number: 20080139464
    Abstract: The invention relates to peptides which consist of amino acid sequences found in the NY-ESO-1 molecule, which bind to MHC-Class II molecules. These can be used alone, or in combination with other peptides.
    Type: Application
    Filed: May 27, 2004
    Publication date: June 12, 2008
    Applicants: LUDWIG INSTITUTE OF CANCER RESEARCH, MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Sacha Gnjatic, Djordje Atanackovic, Lloyd J. Old
  • Method for generating an immune response and reagents therefor
    Patent number: 7259235
    Abstract: Isolated peptides are disclosed which, when processed, generate a coordinated immune response.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: August 21, 2007
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Lloyd J. Old, Sacha Gnjatic
  • Method for generating an immune response and reagents therefor
    Publication number: 20060204507
    Abstract: Isolated peptides are disclosed which, when processed, generate a coordinated immune response.
    Type: Application
    Filed: September 26, 2003
    Publication date: September 14, 2006
    Inventors: Lloyd Old, Sacha Gnjatic
  • Isolated peptides which bind to HLA-C molecules and uses thereof
    Patent number: 7009035
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: March 7, 2006
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc., Memorial Sloan-Kettering Cancer Center
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth
  • Isolated peptides which bind to HLA molecules and uses thereof
    Publication number: 20030175250
    Abstract: This invention relates to isolated peptides that bind to an HLA molecule particularly HLA-A3, HLA-B35 and/or HLA-B51 and stimulate cytolytic T cells specific for complexes of the peptide and the HLA molecule. This invention also relates to CTLs, antibodies, antibody fragments and T cell receptors that are specific for HLA/peptide complexes, and to methods of using the peptides, CTLs, antibodies and receptors.
    Type: Application
    Filed: February 12, 2003
    Publication date: September 18, 2003
    Inventors: Elke Jager, Alexander Knuth, Lloyd J. Old, Sacha Gnjatic
  • Isolated peptides which bind to HLA-C molecules and uses thereof
    Publication number: 20030050451
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Application
    Filed: October 18, 2002
    Publication date: March 13, 2003
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth
  • Isolated peptides which bind to HLA-C molecules and uses thereof
    Patent number: 6506875
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: January 14, 2003
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth