Patents by Inventor Sachin Gavhane

Sachin Gavhane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMORPHIC FORMS OF A ROR INHIBITING COMPOUND AND PROCESSES FOR ITS PREPARATION
    Publication number: 20230312486
    Abstract: The present invention is directed to solid state forms of a compound which has retinoid-related orphan receptor gamma (RORy) modulator activity. Particularly the present invention relates to solid state forms of the compound (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl) acetamide, processes for their preparation, pharmaceutical compositions containing the same and their use in therapy. More, particularly the present invention relates to crystalline form of the compound (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl)acetamide, processes for their preparation, pharmaceutical compositions containing the same and their use in therapy.
    Type: Application
    Filed: September 3, 2021
    Publication date: October 5, 2023
    Inventors: Sanjib DAS, Sachin Sundarlal CHAUDHARI, Laxmikant Atmaram GHARAT, Suresh Mahadev KADAM, Sachin GAVHANE, Bipin Parsottam KANSAGRA, Shailesh Shrirang PAWASE, Anil Subhash BHUJBAL, Ulhas Digambar PATIL, Sunil Pandurang NIRGUDE
  • Polymorphs of a mPGES-1 inhibiting triazolone compound
    Patent number: 10457649
    Abstract: The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl)pivalamide (Compound of formula II), and process for preparation thereof.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: October 29, 2019
    Assignee: GLENMARK PHARMACEUTICALS S.A.
    Inventors: Nagarajan Muthukaman, Laxmikant A. Gharat, Suresh M. Kadam, Sachin Gavhane, Sandeep B. Khandagale, Sunil P. Nirgude
  • POLYMORPHS OF A mPGES-1 INHIBITING TRIAZOLONE COMPOUND
    Publication number: 20180370923
    Abstract: The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl) pivalamide (Compound of formula II), and process for preparation thereof.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Inventors: Nagarajan Muthukaman, Laxmikant A. Gharat, Suresh M. Kadam, Sachin Gavhane, Sandeep B. Khandagale, Sunil P. Nirgude
  • Polymorphs of a mPGES-1 inhibiting triazolone compound
    Patent number: 10112914
    Abstract: The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl) pivalamide (Compound of formula II), and process for preparation thereof.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 30, 2018
    Assignee: GLENMARK PHARMACEUTICALS S.A.
    Inventors: Nagarajan Muthukaman, Laxmikant A. Gharat, Suresh M. Kadam, Sachin Gavhane, Sandeep B. Khandagale, Sunil P. Nirgude
  • POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND
    Publication number: 20180134671
    Abstract: The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl) pivalamide (Compound of formula II), and process for preparation thereof.
    Type: Application
    Filed: June 13, 2016
    Publication date: May 17, 2018
    Inventors: Nagarajan Muthukaman, Laxmikant A. Gharat, Suresh M. Kadam, Sachin Gavhane, Sandeep B. Khandagale, Sunil P. Nirgude
  • Amides of 2-amino-4-arylthiazole compounds and their salts
    Patent number: 9458173
    Abstract: The present disclosure is directed to salts of N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide and process for the preparation thereof (formula II).
    Type: Grant
    Filed: June 8, 2013
    Date of Patent: October 4, 2016
    Assignee: GLENMARK PHARMACEUTICALS S.A.
    Inventors: Suresh Mahadev Kadam, Abraham Thomas, Sukumar Sinha, Sukeerthi Kumar, Bipin Parsottam Kansagra, Sachin Gavhane, Sandeep Bandu Khandagale, Shailesh Pawase, Jayant Prakashrao Patil, Shailendra Bhadane, Bhavna Mishra, Rajesh Dwivedi
  • AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS
    Publication number: 20150111038
    Abstract: The present disclosure is directed to salts of N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide and process for the preparation thereof (formula II).
    Type: Application
    Filed: June 8, 2013
    Publication date: April 23, 2015
    Applicant: GLENMARK PHARMACEUTICALS S.A.
    Inventors: Suresh Mahadev Kadam, Abraham Thomas, Sukumar Sinha, Sukeerthi Kumar, Bipin Parsottam Kansagra, Sachin Gavhane, Sandeep Bandu Khandagale, Shailesh Pawase, Jayant Prakashrao Patil, Shailendra Bhadane, Bhavna Mishra, Rajesh Dwivedi
  • Process for preparation of substantially pure glimepiride
    Publication number: 20070082943
    Abstract: The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HCl and 4[-2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide (I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride usingS methanolic ammonia and glacial acetic acid to obtain highly pure Glimepiride Form I (I) having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.
    Type: Application
    Filed: June 17, 2005
    Publication date: April 12, 2007
    Inventors: Suresh Kadam, Venkatasubramanian Tarur, Sanjay Naik, Sachin Gavhane