Patents by Inventor Sadna Budhu

Sadna Budhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating an infectious or neoplastic disease
    Patent number: 10912798
    Abstract: A method is provided, inter alia, for treating a subject suffering from an infectious or neoplastic disease with immunotherapy. The method includes determining the critical concentration of immune cells required to treat or eradicate an infectious or neoplastic disease in the subject using an in vitro assay of the present invention; and administering to the subject the critical concentration of immune cells determined in the assay.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: February 9, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Samuel C. Silverstein, John D. Loike, Sadna Budhu, Peter Lee
  • METHODS, FOR TREATING AN INFECTIOUS OR NEOPLASTIC DISEASE
    Publication number: 20190038673
    Abstract: An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8+ T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8+ T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8+ T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.
    Type: Application
    Filed: October 9, 2018
    Publication date: February 7, 2019
    Inventors: Samuel C. Silverstein, John D. Loike, Sadna Budhu, Peter Lee
  • Methods for treating an infectious or neoplastic disease
    Patent number: 10137153
    Abstract: A method is provided for treating a subject suffering from an infectious or neoplastic disease with immunotherapy. The method comprises determining the critical concentration of immune cells required to treat or eradicate an infectious or neoplastic disease in the subject using an in vitro assay of the present invention; and administering to the subject the critical concentration of immune cells determined in the assay.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: November 27, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Samuel C. Silverstein, John D. Loike, Sadna Budhu, Peter Lee
  • ASSAYS FOR DETERMINING THE EFFECT OF AN IMMUNE CELL ON A CELL FROM AN INFECTIOUS OR NEOPLASTIC DISEASE
    Publication number: 20170106022
    Abstract: An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8+ T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8+ T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8+ T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.
    Type: Application
    Filed: November 7, 2016
    Publication date: April 20, 2017
    Inventors: Samuel C. Silverstein, John D. Loike, Sadna Budhu, Peter Lee
  • Assays for determining the effect of an immune cell on a cell from an infectious or neoplastic disease
    Patent number: 9488644
    Abstract: An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8+ T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8+ T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8+ T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: November 8, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Samuel C. Silverstein, John D. Loike, Sadna Budhu, Peter P. Lee
  • METHODS, COMPOSITIONS, AND ASSAYS FOR DETERMINING THE EFFECT OF AN IMMUNE CELL ON A CELL FROM AN INFECTIOUS OR NEOPLASTIC DISEASE
    Publication number: 20130064802
    Abstract: An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8+ T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8+ T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8+ T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.
    Type: Application
    Filed: November 11, 2010
    Publication date: March 14, 2013
    Inventors: Samuel C. Silverstein, John D. Loike, Sadna Budhu, Peter Lee