Patents by Inventor Saheem ZAIDI

Saheem ZAIDI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20230111856
    Abstract: The first selective SuFEx antagonists to ?-opioid receptors (MOR) were developed by functionalizing an opioid scaffold with an SO2—F warhead. Our model, based on a MOR structure with antagonist ?-FNA, indicates the naloxone carbonyl as an advantageous point for derivatization as it is chemically accessible and is not involved in interaction with receptors. Of the three accessible Tyr residues in MOR pocket, Tyr77, Tyr130 and Tyr150, Tyr150 in proximity to the carbonyl of the docked naloxone was selected as a target, which resulted in the development of highly potent antagonists.
    Type: Application
    Filed: March 2, 2021
    Publication date: April 13, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Vsevolod KATRITCH, Valery V. FOKIN, Saheem ZAIDI, Joice THOMAS
  • G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
    Patent number: 11613547
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: March 28, 2023
    Assignees: University of Health Sciences & Pharmacy in St. Louis, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
    Inventors: Susruta Majumdar, Vsevolod Katritch, Bryan Roth, Jay McLaughlin, Saheem Zaidi, Gavril W. Pasternak, Rajendra Uprety
  • G-PROTEIN BIASED OPIOID RECEPTOR AGONIST/ANALGESICS WITH REDUCED ARRESTIN RECRUITMENT
    Publication number: 20210061814
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
    Type: Application
    Filed: July 8, 2020
    Publication date: March 4, 2021
    Applicants: St. Louis College of Pharmacy, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
    Inventors: Susruta MAJUMDAR, Vsevolod KATRITCH, Bryan ROTH, JAY MCLAUGHLIN, Saheem ZAIDI, Gavril W. PASTERNAK, Rajendra UPRETY