Patents by Inventor Saili Yi

Saili Yi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purifying microglial cells by binding cell Fc receptor to immunoglobulin G Fc domain
    Patent number: 6586239
    Abstract: A method is provided for obtaining a cell population enriched in microglial cells by contacting a composition containing microglial cells with immunoglobulin immobilized on a matrix such as a polystyrene matrix before or after contact with the cells, allowing the cells to bind to the with immunoglobulin, and removing non-adherent cells to obtain a cell population containing preferably at least 95% microglial cells. The immunoglobulin may be Fc domain-containing immunoglobulin G, and Fc receptors of the microglial cells bind to the Fc domain of immunoglobulin G. Purified Fc fragments from immunoglobulin G may be used in place of immunoglobulin G. The microglial cells may be from brain tissue, and from tissue of a normal animal or tissue of an animal having a neurological disorder.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: July 1, 2003
    Assignee: AGY Therapeutics, Inc.
    Inventors: Huaiyu Mi, Saili Yi