Patents by Inventor Saiyong Zhu

Saiyong Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for producing pancreatic beta cells
    Patent number: 11332716
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: May 17, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
    Inventors: Matthias Hebrok, Holger Andreas Russ, Sheng Ding, Saiyong Zhu
  • REPROGRAMMING OF CELLS TO A NEW FATE
    Publication number: 20210189348
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Application
    Filed: January 22, 2021
    Publication date: June 24, 2021
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • REPROGRAMMING CELLS
    Publication number: 20210095257
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: June 25, 2020
    Publication date: April 1, 2021
    Inventors: Saiyong Zhu, Sheng Ding
  • Reprogramming of cells to a new fate
    Patent number: 10934528
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: March 2, 2021
    Assignee: The Scripps Research Institute
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Reprogramming cells
    Patent number: 10738281
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: August 11, 2020
    Assignee: The Scripps Research Institute
    Inventors: Saiyong Zhu, Sheng Ding
  • REPROGRAMMING OF CELLS TO A NEW FATE
    Publication number: 20190376041
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Application
    Filed: April 17, 2019
    Publication date: December 12, 2019
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • REPROGRAMMING CELLS
    Publication number: 20190203182
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: January 3, 2019
    Publication date: July 4, 2019
    Inventors: Saiyong Zhu, Sheng Ding
  • Reprogramming of cells to a new fate
    Patent number: 10308912
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: June 4, 2019
    Assignee: The Scripps Research Institute
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Generating hepatocytes
    Patent number: 10227565
    Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 12, 2019
    Assignees: The J. David Gladstone Institutes, The Regents of the University of California
    Inventors: Saiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
  • Reprogramming cells
    Patent number: 10214729
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: February 26, 2019
    Assignee: The Scripps Research Institute
    Inventors: Saiyong Zhu, Sheng Ding
  • Methods and Compositions for Producing Pancreatic Beta Cells
    Publication number: 20180216076
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Inventors: Matthias Hebrok, Holger Andreas Russ, Sheng Ding, Saiyong Zhu
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180171303
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 21, 2018
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9926533
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: March 27, 2018
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Generating definitive endoderm and pancreatic progenitor cells
    Patent number: 9909104
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of definitive endoderm cells, posterior foregut-like progenitor cells, pancreatic progenitor cells and/or pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: March 6, 2018
    Assignee: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
    Inventors: Sheng Ding, Ke Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180002671
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 4, 2018
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • REPROGRAMMING CELLS
    Publication number: 20170283776
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: April 17, 2017
    Publication date: October 5, 2017
    Inventors: Saiyong Zhu, Sheng Ding
  • Chemical approaches for generation of induced pluripotent stem cells
    Patent number: 9771563
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 26, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • REPROGRAMMING OF CELLS TO A NEW FATE
    Publication number: 20170159019
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 8, 2017
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Reprogramming cells
    Patent number: 9657274
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 23, 2017
    Assignee: The Scripps Research Institute
    Inventors: Saiyong Zhu, Sheng Ding
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20170081640
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 23, 2017
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu