Abstract: Provided are vision care kits and methods of their use. The kits contain first and second contact lenses having different primary functionalities or modalities, or both. The kits allow contact lens wearers to experience greater flexibility and customizability from their contact lenses.

Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent having reservoirs so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.

Abstract: A contact lens incorporating one or more compliant dynamic translation zones fabricated from a material that is readily deformable under eyelid pressure during blinking and which allows for the control over translation of the contact lens on the eye. The one or more compliant dynamic translation zones provide for the comfortable relative movement of the contact lens over the eye.

Abstract: Static images or patterns may be incorporated into one or more regions of a cosmetic contact lens to achieve a new dimensional effect; namely, the appearance or illusion of motion. More particularly, repeated asymmetric patterns with the appropriate contrast and luminance incorporated into one or more regions of the contact lens will result in the one or more regions providing the appearance of motion. Other optical or visual illusions may also be incorporated into a cosmetic contact lens.

Abstract: A contact lens incorporating one or more dynamic fluid zones fabricated from a material that is readily deformable under eyelid pressure during blinking allows for the delivery of one or more agents to the eye, dynamic cosmetic eye enhancement, and/or dynamic rotational misalignment correction. The one or more agents may include therapeutic agents, nutritional agents and pharmacological agents.

Abstract: The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises an expandable member releasably or permanently affixed to a delivery system which facilitates placement and advancement of a second delivery system.

Abstract: A contact lens incorporating one or more compliant dynamic translation zones fabricated from a material that is readily deformable under eyelid pressure during blinking and which allows for the control over translation of the contact lens on the eye. The one or more compliant dynamic translation zones provide for the comfortable relative movement of the contact lens over the eye.

Abstract: A contact lens incorporating one or more dynamic fluid zones fabricated from a material that is readily deformable under eyelid pressure during blinking allows for the delivery of one or more agents to the eye, dynamic cosmetic eye enhancement, and/or dynamic rotational misalignment correction. The one or more agents may include therapeutic agents, nutritional agents and pharmacological agents.

Abstract: A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form.

Abstract: Methods and devices are provided for providing access through tissue to a surgical site. Generally, the methods and devices allow adjustment of a surgical access port's longitudinal length. In one embodiment, a surgical access port is provided that includes a housing having a cannula distally extending therefrom. The housing can be configured to cut a proximal portion of the cannula to adjust a longitudinal length of the cannula and hence of the surgical access port. In another embodiment, a surgical access port is provided that includes a cannula formed of a plurality of modular segments removably coupled together. One or more of the segments can be configured to be removable from the cannula to change the cannula's longitudinal length.

Abstract: Methods and devices are provided for accessing a surgical site. In one embodiment, an access device is provided having a housing and a cannula extending distally therefrom. The cannula and the housing can define a working channel extending longitudinally therethrough. The cannula can be movable between an insertion configuration and a deployed configuration. The access device can also include an obturator insertable through the working channel. In one embodiment, the obturator can be configured to selectively mate with the cannula such that rotation of the obturator is effective to cause corresponding rotation of the cannula. In another embodiment, the obturator can be configured to move the cannula from the insertion configuration to the deployed configuration when the obturator is fully disposed within the cannula.

Abstract: An aneurysmal repair system that utilizes a modified intraluminal scaffold apex and a delta stitch suture to secure graft material to the scaffold structure allows for no relative movement between the graft material and the scaffold structure. The absence of relative movement reduces the wear on the graft material.

Abstract: A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.

Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent having reservoirs so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.

Abstract: Methods and devices are provided for providing access through tissue to a surgical site. Generally, the methods and devices allow adjustment of a surgical access port's longitudinal length. In one embodiment, a surgical access port is provided that includes a housing having a cannula distally extending therefrom. The housing can be configured to cut a proximal portion of the cannula to adjust a longitudinal length of the cannula and hence of the surgical access port. In another embodiment, a surgical access port is provided that includes a cannula formed of a plurality of modular segments removably coupled together. One or more of the segments can be configured to be removable from the cannula to change the cannula's longitudinal length.

Abstract: Methods and devices are provided for accessing a surgical site. In one embodiment, an access device is provided having a housing and a cannula extending distally therefrom. The cannula and the housing can define a working channel extending longitudinally therethrough. The cannula can be movable between an insertion configuration and a deployed configuration. The access device can also include an obturator insertable through the working channel. In one embodiment, the obturator can be configured to selectively mate with the cannula such that rotation of the obturator is effective to cause corresponding rotation of the cannula. In another embodiment, the obturator can be configured to move the cannula from the insertion configuration to the deployed configuration when the obturator is fully disposed within the cannula.

Abstract: A stent may be inserted into a vessel in order to open and then maintain the patency of the vessel. The stent has a strut design that increases the overall fatigue resistance of the stent. Each strut is tapered to better distribute strain and thus increase fatigue resistance. In addition, some of the struts may comprise protrusions to increase the pushability of the stent during loading into a delivery device.