Patents by Inventor Sam J. Milstein

Sam J. Milstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric delivery agents and delivery agent compounds
    Patent number: 7727558
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: June 1, 2010
    Assignees: Emisphere Technologies, Inc., Virginia Commonwealth University
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John Smart, Richard Conticello, Raphael Ottenbrite
  • Compounds and compositions for delivering active agents
    Patent number: 7417022
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: August 26, 2008
    Assignee: MHR Institutional Partners IIA LP
    Inventors: Andrea Leone-Bay, Sam J. Milstein, Donald J. Sarubbi, Harry Leipold
  • Carbon-substituted diketopiperazine delivery systems
    Patent number: 7276534
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: October 2, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventor: Sam J. Milstein
  • Polymeric delivery agents and delivery agent compounds
    Patent number: 7208483
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: April 24, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Compounds and compositions for delivering active agents
    Patent number: 7067119
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: June 27, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Oral drug delivery compositions and methods
    Patent number: 7005141
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: February 28, 2006
    Assignee: Emisphere Technologies Inc.
    Inventors: Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
  • Compounds and compositions for delivering active agents
    Patent number: 6972300
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: December 6, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Patent number: 6960355
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: November 1, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Sam J. Milstein, Donald J. Sarrubi, Harry Leipold
  • Active agent transport systems
    Patent number: 6916489
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: July 12, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Fang Wang, Donald J. Sarubbi, Noemi B Santiago
  • Carbon-substituted diketopiperazine delivery systems
    Patent number: 6906030
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: June 14, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventor: Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Publication number: 20040110839
    Abstract: Modified, amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Application
    Filed: July 18, 2003
    Publication date: June 10, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compositions for the delivery of antigens
    Publication number: 20040062773
    Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
    Type: Application
    Filed: June 19, 2003
    Publication date: April 1, 2004
    Applicant: Emisphere Technologies Inc.
    Inventors: Noemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch
  • Compounds and compositions for delivering active agents
    Patent number: 6699467
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: March 2, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Pulmonary delivery of active agents
    Patent number: 6693073
    Abstract: The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Polymeric delivery agents and delivery agent compounds
    Publication number: 20030232085
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: May 28, 2003
    Publication date: December 18, 2003
    Applicants: Emisphere Technologies, Inc., Virginia Commonwealth University
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Carbon-substituted diketopiperazine delivery systems
    Patent number: 6663898
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: December 16, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventor: Sam J. Milstein
  • Polymeric delivery agents and delivery agents compounds
    Patent number: 6627228
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 30, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Compounds and compositions for delivering active agents
    Patent number: 6623731
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: September 23, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compositions for the delivery of antigens
    Patent number: 6610329
    Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: August 26, 2003
    Assignee: Emisphere Technologies Inc.
    Inventors: Noemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch
  • Active agent transport systems
    Publication number: 20030133953
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer.
    Type: Application
    Filed: September 25, 2002
    Publication date: July 17, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Fang Wang, Donald J. Sarubbi, Noemi B. Santiago