Patents by Inventor Sam T. Hess
Sam T. Hess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8217992Abstract: A method of performing 3D photoactivation microscope imaging includes providing a sample having a plurality of probes, each of the plurality of probes including a photo-activatable material. Probes from the plurality of probes are activated to form a sparse subset of probes, the sparse subset of probes having probes that are spatially separated by at least a microscope resolution. The sample is illuminated with a readout light source, and light emitted from activated probes is detected. Based on the light emission detected from the activated probes, localized three-dimensional positions of the activated probes are obtained.Type: GrantFiled: January 11, 2008Date of Patent: July 10, 2012Assignees: The Jackson Laboratory, University of MaineInventors: Joerg Bewersdorf, Michael Darin Mason, Sam T. Hess
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Patent number: 7880149Abstract: A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.Type: GrantFiled: June 29, 2010Date of Patent: February 1, 2011Assignees: The Jackson Laboratory, University of MaineInventors: Joerg Bewersdorf, Manuel F. Juette, Travis Gould, Sam T. Hess
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Publication number: 20100283835Abstract: A method of performing 3D photoactivation microscope imaging includes providing a sample having a plurality of probes, each of the plurality of probes including a photo-activatable material. Probes from the plurality of probes are activated to form a sparse subset of probes, the sparse subset of probes having probes that are spatially separated by at least a microscope resolution. The sample is illuminated with a readout light source, and light emitted from activated probes is detected. Based on the light emission detected from the activated probes, localized three-dimensional positions of the activated probes are obtained.Type: ApplicationFiled: January 11, 2008Publication date: November 11, 2010Inventors: Joerg Bewersdorf, Michael Darin Mason, Sam T. Hess
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Publication number: 20100265318Abstract: A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.Type: ApplicationFiled: June 29, 2010Publication date: October 21, 2010Applicants: The Jackson Laboratory, University of MaineInventors: Joerg Bewersdorf, Manuel F. Juette, Travis Gould, Sam T. Hess
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Patent number: 7772569Abstract: A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.Type: GrantFiled: April 1, 2008Date of Patent: August 10, 2010Assignees: The Jackson Laboratory, University of MaineInventors: Joerg Bewersdorf, Manuel F. Juette, Travis Gould, Sam T. Hess
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Publication number: 20090242798Abstract: A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.Type: ApplicationFiled: April 1, 2008Publication date: October 1, 2009Applicants: The Jackson Laboratory, University of MaineInventors: Joerg Bewersdorf, Manuel F. Juette, Travis Gould, Sam T. Hess