Abstract: Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.

Abstract: In one general aspect, a method can include causing display of a webpage within a display area of a browser, and causing display of a search area indicator associated with an area of the webpage. The method can include receiving a selection of the search area indicator. In response to the selection of the search area indicator being received the method can include defining an image corresponding to the area, and triggering a search query based on the image. The method can include receiving a search result in response to the search query, and causing display of the search result in a search result area outside of the display area where the search result area is within the browser.

Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal introitus and, optionally, external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion and a silicone wax having a melting temperature of from about 24° C. to about 50° C. The vaginal care composition can also comprise silicone particles. The vaginal care composition can have a viscosity of from about 20,000 cps to about 200,000 cps.

Abstract: The present disclosure relates to compositions comprising an aqueous solution of at least about 70% by weight water in combination with selected fatty acid salts and optionally an alcohol and/or a cooling sensate, as well as methods of using the same to treat symptoms of hot flashes. The fatty acid salts form fiber-like crystalline particles that together form a self-supporting mesh structure with voids, the aqueous solution being contained in the voids. When the composition is compressed above a critical stress, the mesh allows for the entrapped aqueous solution to be expressed.

Abstract: A kit for treating vaginal dryness is provided. The kit comprises a hand held applicator and a dispenser or receptacle storing a vaginal care composition.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal introitus and, optionally, external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion and a silicone wax having a melting temperature of from about 24° C. to about 50° C. The vaginal care composition can also comprise silicone particles. The vaginal care composition can have a viscosity of from about 20,000 cps to about 200,000 cps.

Abstract: The present disclosure generally relates to an applicator for administering a composition for treating one or more of vaginal dryness, vaginal irritation, vaginal itch, vaginal infection, vaginal odor, vaginal chafing, dyspareunia, and/or vaginal atrophy, and more specifically, to an applicator comprising a reservoir and a vaginal care composition stored within the reservoir, as well as methods of using such an applicator.

Abstract: A natural vaginal care composition is provided. The natural composition includes a biobased vaginal care agent; a biobased thickener; and at least 60% water. The natural composition may optionally include a biobased preservative, a biobased emulsifier, and a biobased pH adjuster. The natural vaginal care composition is suitable for treating symptoms of vaginal atrophy and/or dryness.

Abstract: Devices with one or more dosing indicator symbols to signal to a user how much material should be dispensed. A whitening pen with a first dosing indicator on the body and a second dosing indicator on the rotating portion that can allow a user to dispense a known amount of a whitening composition.

Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.

Abstract: A method of treating vaginal atrophy is provided. The method comprises administering a vaginal care composition to vaginal tissue of a user experiencing a symptom of vaginal atrophy. The vaginal care composition may include an effective amount of a vaginal care agent selected to specifically treat symptoms of vaginal atrophy exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.

Abstract: The present disclosure generally relates to an applicator for administering a composition for treating one or more of vaginal dryness, vaginal irritation, vaginal itch, vaginal infection, vaginal odor, vaginal chafing, dyspareunia, and/or vaginal atrophy, and more specifically, to an applicator comprising a receptacle comprising a first portion, a second portion, and an attachment structure, where the first portion and second portion are removably attached to define a substantially spherical shape, where a vaginal care composition is stored within the receptacle.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal area, preferably the vaginal introitus and/or external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion, from about 60% to about 95% water, by weight of the vaginal care composition, a preservative selected from the group consisting of aromatic alcohol preservatives, organic acid preservatives, salts thereof, and combinations thereof, and a preservative enhancing agent. The preservative enhancing agent can comprise sorbitan caprylate. The vaginal care composition can have a pH of from about 4.0 to about 5.5.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user providing an amount of a vaginal care composition on at least a portion of the outer surface of an applicator and administering at least a portion of the amount of the vaginal care composition to her vaginal introitus and, optionally, one or more of her vulva, vestibule, labia majora, labia minora, or external urogenital tract while grasping and manipulating the applicator. The vaginal care composition can comprise an oil-in-water emulsion and a thickener comprising a polyacrylamide polymer and a fatty alcohol.

Abstract: A kit for treating vaginal dryness is provided. The kit comprises a hand held applicator and a dispenser or receptacle storing a vaginal care composition.

Abstract: The present disclosure is generally directed to pants that include reusable outer covers and disposable absorbent inserts.

Abstract: A wearable absorbent article comprises a reusable outer cover and a disposable absorbent insert. The reusable outer cover comprises a first insert fastener component in a front waist region proximate to a waist opening edge of the reusable outer cover. The first insert fastener component comprises a first end positioned most proximate to the waist opening edge and a second end positioned most distal from the waist opening edge. An insert-gripping recess is formed in the first end in an area covering a longitudinal axis of the reusable outer cover. The disposable absorbent insert comprises a first fastener component in a forward region of the insert and configured to be joined to the first insert fastener component to attach the insert to the reusable outer cover.

Abstract: A reusable outer cover configured to be engaged with a disposable absorbent insert is provided. The reusable outer cover comprises front and rear waist regions configured to be joined together by a fastening zone. The fastening zone comprises a first side on the front waist region and a second side on the rear waist region. The first side comprises a first portion and a second portion. The first portion comprises a first fastening component and the second portion comprises a second fastening component. The second side comprises a third portion and a fourth portion. The third portion comprises a third fastening component and the fourth portion comprises a fourth fastening component. The first and third fastening components have a first fastening property and the second and fourth fastening components have a second, different fastening property.

Abstract: The present disclosure is generally directed to pants that include reusable outer covers and disposable absorbent inserts.