Patents by Inventor Sami Karaborni

Sami Karaborni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20240156741
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: January 24, 2024
    Publication date: May 16, 2024
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
  • Pharmaceutical compositions of dimethyl fumarate
    Patent number: 11938111
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: March 26, 2024
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • Modified release compositions of a GAMMA-hydroxybutyric acid derivative
    Patent number: 11925710
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: March 12, 2024
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
  • ORAL DOSAGE FORMS HAVING A HIGH LOADING OF A METHYL HYDROGEN FUMARATE PRODRUG
    Publication number: 20240024249
    Abstract: Oral dosage forms and granulations with a high loading of a methyl hydrogen fumarate prodrug are disclosed.
    Type: Application
    Filed: June 13, 2023
    Publication date: January 25, 2024
    Inventors: Sarina Grace Harris MA, Laura Elizabeth BAUER, Sami KARABORNI, David J. WUSTROW, Peter A. VIRSIK
  • COCRYSTALS OF AN ADENOSINE A2B RECEPTOR ANTAGONIST
    Publication number: 20230365564
    Abstract: Cocrystals of an adenosine A2B receptor antagonist, 3-ethyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-3,7-dihydro-1H-purine-2,6-dione, methods of preparing the cocrystals, pharmaceutical compositions of the cocrystals, and uses of the cocrystals are disclosed.
    Type: Application
    Filed: September 3, 2021
    Publication date: November 16, 2023
    Inventors: Jiwen LIU, Drazen OSTOVIC, Sami KARABORNI
  • PHARMACEUTICAL COMPOSITIONS AND ORAL DOSAGE FORMS OF KETAMINE DERIVATIVES
    Publication number: 20230285325
    Abstract: Pharmaceutical compositions of ketamine derivatives and oral dosage forms comprising the pharmaceutical compositions are disclosed. Solid oral dosage forms prepared from the pharmaceutical compositions exhibit a zero-order release profile.
    Type: Application
    Filed: May 17, 2023
    Publication date: September 14, 2023
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, WILLIAM W. XIANG, JIA-NING XIANG
  • Solid forms of Cerdulatinib
    Patent number: 11713309
    Abstract: Forms of cerdulatinib and salts or co-crystals thereof were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the forms cerdulatinib and salts or co-crystals thereof.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: August 1, 2023
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Anjali Pandey, Julian Scott Northen, Philippe Fernandes, Ying Chen, Yuelie Lu, Sami Karaborni, Gus Kodersha
  • Pharmaceutical compositions and oral dosage forms of ketamine derivatives
    Patent number: 11690811
    Abstract: Pharmaceutical compositions of ketamine derivatives and oral dosage forms comprising the pharmaceutical compositions are disclosed. Solid oral dosage forms prepared from the pharmaceutical compositions exhibit a zero-order release profile.
    Type: Grant
    Filed: August 12, 2022
    Date of Patent: July 4, 2023
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, William W. Xiang, Jia-Ning Xiang
  • Solid forms of Cerdulatinib
    Patent number: 11661414
    Abstract: Forms of cerdulatinib and salts or co-crystals thereof were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the forms cerdulatinib and salts or co-crystals thereof.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: May 30, 2023
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Anjali Pandey, Julian Scott Northen, Philippe Fernandes, Ying Chen, Yuelie Lu, Sami Karaborni, Gus Kodersha
  • PHARMACEUTICAL COMPOSITIONS AND ORAL DOSAGE FORMS OF KETAMINE DERIVATIVES
    Publication number: 20230098084
    Abstract: Pharmaceutical compositions of ketamine derivatives and oral dosage forms comprising the pharmaceutical compositions are disclosed. Solid oral dosage forms prepared from the pharmaceutical compositions exhibit a zero-order release profile.
    Type: Application
    Filed: August 12, 2022
    Publication date: March 30, 2023
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, WILLIAM W. XIANG, JIA-NING XIANG
  • PHARMACEUTICAL GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20220323366
    Abstract: Granulations with granules having a high loading of an active pharmaceutical ingredient are disclosed. The active pharmaceutical ingredient has a high aqueous water solubility. The granules have a narrow particle size distribution and a smooth exterior surface.
    Type: Application
    Filed: May 5, 2022
    Publication date: October 13, 2022
    Inventors: Sami KARABORNI, William W. XIANG, Daniel M. CANAFAX, Jia-Ning XIANG
  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20220323365
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 13, 2022
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
  • Modified release compositions of a gamma-hydroxybutyric acid derivative
    Patent number: 11395801
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: July 26, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
  • CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20220183977
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: March 4, 2022
    Publication date: June 16, 2022
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, NICOLAS D. KIRKLAND
  • Pharmaceutical granulations of water-soluble active pharmaceutical ingredients
    Patent number: 11357734
    Abstract: Granulations with granules having a high loading of an active pharmaceutical ingredient are disclosed. The active pharmaceutical ingredient has a high aqueous water solubility. The granules have a narrow particle size distribution and a smooth exterior surface.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: June 14, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, William W. Xiang, Daniel M. Canafax, Jia-Ning Xiang
  • Controlled release granulations of water-soluble active pharmaceutical ingredients
    Patent number: 11304906
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: April 19, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Nicolas D. Kirkland
  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20220105044
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: October 5, 2021
    Publication date: April 7, 2022
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
  • Pharmaceutical Compositions of Dimethyl Fumarate
    Publication number: 20220105067
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • Pharmaceutical compositions of dimethyl fumarate
    Patent number: 11229621
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: January 25, 2022
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • PHARMACEUTICAL GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20210393537
    Abstract: Granulations with granules having a high loading of an active pharmaceutical ingredient are disclosed. The active pharmaceutical ingredient has a high aqueous water solubility. The granules have a narrow particle size distribution and a smooth exterior surface.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 23, 2021
    Inventors: Sami KARABORNI, William W. XIANG, Daniel M. CANAFAX, Jia-Ning XIANG